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18 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 19 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA 20 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA µ 1µg/ml µ 2µg/ml µ µ 4µg/ml 8µg/ml 250/125 40% 500/125 55% 43% 875/125 44% 40% 875/125 69% 57% 34% 1000/125 >65% 55% 41% 2000/125 >70% 60% 49% 35% 1µg/ml 2µg/ml 4µg/ml 8µg/ml 40/10 mg/kg/ ngày 59% 44% 45/6,4 mg/kg/ ngày 50% 41% 90/6,4 mg/kg/ ngày 61% 50% 125/31,25 hay 250/62,5 mg/5 ml (4:1) 200/28,5 hay 400/57 mg/5 ml (7:1) 600/42,9 mg/5 ml (14:1) Hô hấp số 11/2017 41% 21 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ 22 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 23 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA 24 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 25 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA 26 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 27 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA Grant W Waterer; Jordi Rello; Richard G Wunderink Management of Community-acquired Pneumonia in Adults (Concise Clinical Review) Am 2011 Richard G Wunderink; Grant W Waterer Community-Acquired Pneumonia N Engl J Med 2014; 370:543-51 2012; 11-140 M Woodhead, F Blasi, S Ewig et al Guidelines for the management of adult lower respiratory tract infections - full version Clin Microbiol Infect 2011; 17(Suppl 6): E1-E59 Daniel M Musher; Anna R Thorner CommunityAcquired Pneumonia N Engl J Med 2014; 371:1619-28 28 Hô hấp số 11/2017 Lionel A Mandell; Richard G Wunderink; Antonio Anzueto et al Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of CommunityAcquired Pneumonia in Adults Clinical Infectious Diseases 2007; 44:S27-72 W S Lim; M M van der Eerden; R Laing; et al Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study Thorax 2003; 58:377-382 James D Chalmers; Joanne K Taylor; Pallavi Society of America/American Thoratic Society Minor Criteria for Intensive Care Unit Admission in Community-Acquired Pneumonia Patients Without Major Criteria or Contraindications to Intensive Care Unit Care Clinical Infectious Diseases 2011; 53(6):503-511 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA 2015 - Annotated BTS Guideline for the management of CAP in adults (2009) Summary of recommendations Thorax 2009; 64:iii1-iii55 10 National Institute for Health and Care Excellence 2014 Pneumonia in adults: diagnosis and management Nice.org.uk/guidance/cg191 11 Gavin Falk; Tom Fahey C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies Family Practice 2008; 26 (1): 10-21 12 Jacob MR Optimizing of antimicrobial therapy using pharmacokinetic and pharmacodynamic characters Clin Microbiol Infect 2001; 7: 589-596 13 White AR et al Amox/Clav (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent Journal of Antimicrobial Chemotherapy 2004; 53(S1): i3-i20 14 Niclas Johansson; Mats Kalin; Annika TiveljungLindell; et al Etiology of Community-Acquired Pneumonia: Increased Microbiological Yield with New Diagnostic Methods Clinical Infectious Diseases 2010; 50:202-9 15 Kensuke Takahashi; Motoi Suzuki; Le Nhat Minh et al The incidence and aetiology of hospitalized community-acquired pneumonia among 2013; 13:296 16 Saito A; Kohno S; Matsushima T; Watanabe A et al Prospective multicenter study of the causative organisms of community-acquired pneumonia in adults in Japan J Infect Chemother 2006; 12(2):639 (ISSN: 1341-321X) Thoracic Society guidelines for the management of community acquired pneumonia in adults: update 2009 Thorax 2009; 64(Suppl III):iii1-iii55 2011 YHTH 85512, 2012 6-11 lactamase - Results from the multicenter study on Medicine 2007; 11: Supplement 3, 47-55 22 Prina E, Ranzani OT, Polverino E, et al Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia Ann Am Thorac Soc 2015; 12(2): 153-60 23 Andre C Kalil; Mark L Metersky; Michael Klompas et al Management of Adults With Hospital-acquired Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society Clinical Infectious Diseases Advance 2016 DOI: 10.1093/cid/ciw353 24 Grant W Waterer Are macrolides now obligatory in severe community-acquired pneumonia? Intensive Care Medicine 2010 , pp 562564 25 Emmet O’Brien M; Restrepo MI; Martin-Loeches I Update on the combination effect of macrolide antibiotics in community-acquired pneumonia Respir Investig 2015; 53(5):201-9 26 Benjamin P Westley; Philip A Chan Questions remain regarding mandatory use of macrolides in community-acquired pneumonia Intensive Care Med 2010; 36:1787 Antero Fernandes, Rui Mealha, Pedro Moreira and Henrique Sabino Usefulness of C-reactive protein in monitoring the severe community-acquired pneumonia clinical course Critical Care 2007; 11: R92 (doi:10.1186/cc6105) Management of community-acquired pneumonia in older adults Ther Adv Infect Dis 2014; 2(1) 3-16 paper - November 2012 Wkly Epidemiol Rec 87 (46): 461-76 Nov 23, 2012; PMID 23210147 29 Centers for disease control and prevention Pneumococcal Disease | Prevention Through on the antibiotic resistance S pneumoniae - The results from 204 clinical isolates Hochiminh City Medicine 2007; 11: Supplement 3, 67-77 30 Esposito S; Principi N Pneumococcal vaccines and the prevention of community-acquired pneumonia Pulm Pharmacol Ther 2015; 32:124-9 Hô hấp số 11/2017 29 ...BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 19 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA 20 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA µ... N ĐỒNG THUẬN BAN CHUYÊN GIA µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ µ 22 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 23 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA... số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô hấp số 11/2017 25 TỔNNGBẢ BIÊ QUAN N ĐỒNG THUẬN BAN CHUYÊN GIA 26 Hô hấp số 11/2017 BIÊN BẢN ĐỒNG THUẬN BAN CHUYÊ TỔNG QUAN N GIA Hô