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UNIVERSITY OF MEDICINE AND PHARMACY IN HO CHI MINH CITY GROUP 4: VITAMIN E Vitamin E Introduction Chemical Structure and Classification Does Deficiency and Toxicity I.Introduction Vitamin E is an antioxidant It may help protect your cells from damage This essential nutrient occurs naturally in many foods It’s also available as a dietary supplement Sometimes, it’s in processed foods Vitamin E is fat-soluble You’ve probably seen rust on your bike or car A similar process of oxidation and accelerated aging takes place in your body when cells are exposed to molecules called free radicals Free radicals weaken and break down healthy cells These molecules may also contribute to heart disease and cancer Free radicals form as a result of normal body processes They cause damage that shortens the life of your cells Chemical structure and classification • Vitamin E is an oil-soluble vitamin There are two types of vitamin E: natural and synthetic • Vitamins of natural origin: extracted from vegetable oils Soybean Maize Barley seed Oily seeds: sunflower seeds • Vitamin E in nature consists of seven different forms of tocopherol and tocotrienol • Tocopherol: All tocopherols have the same phthalocyanines Vitamin E synthetic It is not economically feasible to extract the natural foods, so a synthetic vitamin E is produced However, the effect of Vitamin E synthetic is lower than that of natural origin DOSES • If you eat a normal diet with vegetable oils, green vegetables, ensuring adequate supply of vitamin E is not difficult • Only take vitamin E supplements beyond 30 years of age or when there is evidence of vitamin E deficiency that can not be provided through diet - Vitamin E supplements should only be applied to those with dry skin, low in vitamin E diets - The need for vitamin E supplements is about : Vitamin E is likely safe for most healthy people when taken by mouth or applied to the skin Most people not experience any side effects when taking the recommended daily dose, which is 15 mg Vitamin E Deficiency and toxicity Deficiency < 10 mg/ day Adequacy 15 mg/day Toxicity > 1,000 mg/day - Premature infants: hemolytic anemia - Adults: not well characterized Normal cell membrane integrity, reduced oxidative stress, and molecular functioning Relatively nontoxic Toxicity with supplement Interferes with vitamin K’s role in blood clotting, augmentation of anti-blood clotting medication and increases hemolysis High doses can also cause nausea, diarrhea, stomach cramps, fatigue, weakness, headache, blurred vision, rash, and bruising and bleeding Special Precautions & Warnings Pregnancy Breast-feeding Infants and children Angioplasty, a heart procedure Special Precautions & Warnings Diabetes Heart attack Low levels of vitamin K ... vegetable oils, green vegetables, ensuring adequate supply of vitamin E is not difficult • Only take vitamin E supplements beyond 30 years of age or when there is evidence of vitamin E deficiency... a variety of degenerative diseases, including: • hardening of the arteries • high blood pressure • heart disease • cancer Vitamin E may help people with higher environmental or lifestyle risk... process of oxidation and accelerated aging takes place in your body when cells are exposed to molecules called free radicals Free radicals weaken and break down healthy cells These molecules