DSpace at VNU: Downregulation of CD44 reduces doxorubicin resistance of CD44(+)CD24(-) breast cancer cells

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Editors-in-Chief Author Guidelines Peer Review Guidelines Open Outlook Average Article Statistics 24 Days * from submission to first editorial decision 22 Days * from editorial acceptance to publication *Business days (Mon-Fri) 30971 Papers Published Submit Manuscript Journal Email Alerts Signup for Alerts About Dove Press Open access peer-reviewed scientific and medical journals Learn more Open Access Dove Medical Press is a member of the OAI Learn more Reprints Bulk reprints for the pharmaceutical industry Learn more Favored Authors We offer real benefits to our authors, including fast-track processing of papers Learn more Social Media Back to Browse Journals » OncoTargets and Therapy » Volume Original Research Highly Accessed Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells     Abstract Fulltext Metrics Get Permission Authors Phuc PV, Nhan PLC, Nhung TH, Tam NT, Hoang NM, Tue VG, Thuy DT, Ngoc PK Published 21 June 2011 Volume 2011:4 Pages 71—78 DOI http://doi.org.secure.sci-hub.bz/10.2147/OTT.S21431 Review by Single-blind Peer reviewer comments Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim Ngoc Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh, Vietnam Background: Cells within breast cancer stem cell populations have been confirmed to have a CD44+CD24- phenotype Strong expression of CD44 plays a critical role in numerous types of human cancers CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug The CD44+CD24- breast cancer stem cells were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was decreased after drug treatment We noticed treated cells were more sensitive to doxorubicin, even at low doses, compared with the control groups Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell population Reducing the expression level of CD44, combined with doxorubicin treatment, yields promising results for eradicating breast cancer stem cells in vitro This study opens a new direction in treating breast cancer through gene therapy in conjunction with chemotherapy Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at http://www.dovepress.com.secure.sci-hub.bz/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License By accessing the work you hereby accept the Terms Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed For permission for commercial use of this work, please see paragraphs 4.2 and of our Terms Download Article [PDF] View Full Text [HTML][Machine readable] Other articles by this author: Original Research Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results Pham PV, Le HT, Vu BT, Pham VQ, Le PM, Phan NLC, Trinh NV, Nguyen HTL, Nguyen ST, Nguyen TL, Phan NK OncoTargets and Therapy 2016, 9:4441-4451 Published Date: 21 July 2016 Original Research Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression Phan NLC, Trinh NV, Pham PV OncoTargets and Therapy 2016, 9:49-59 Published Date: 23 December 2015 Original Research Highly Accessed Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations Nguyen ST, Nguyen HL, Pham VQ, Nguyen GT, Tran CD, Phan NK, Pham PV OncoTargets and Therapy 2015, 8:323-334 Published Date: 30 January 2015 Methodology Highly Accessed A simple in vitro method for evaluating dendritic cell-based vaccinations Pham PV, Nguyen NT, Nguyen HM, Khuat LT, Le PM, Pham VQ, Nguyen ST, Phan NK OncoTargets and Therapy 2014, 7:1455-1464 Published Date: 18 August 2014 Original Research Highly Accessed Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment Pham PV, Vu NB, Duong TT, Nguyen TT, Truong NH, Phan NLC, Vuong TG, Pham VQ, Nguyen HM, Nguyen KT, Nguyen NT, Nguyen KG, Khat LT, Le DV, Truong KD, Phan NK OncoTargets and Therapy 2012, 5:77-84 Published Date: May 2012 Readers of this article also read: Review Highly Accessed Causative factors for formation of toxic islet amyloid polypeptide oligomer in type diabetes mellitus Jeong HR, An SSA Clinical Interventions in Aging 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Original Research Highly Accessed Characterization of complexation of poly (N-isopropylacrylamide-co-2(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA Jim Moselhy, Tasnim Vira, Fei-Fei Liu, et al International Journal of Nanomedicine 2009, 4:153-164 Published Date: 24 August 2009 Contact Us • Privacy Policy • Associations & Partners • Testimonials • Sitemap • Terms & Conditions Recommend this site Top â Copyright 2017 • Dove Press Ltd • Website development by maffey.com • Web Design by Adhesion The opinions expressed in all articles published here are those of the specific author(s), and not necessarily reflect the views of Dove Medical Press Ltd or any of its employees страничка проекта Sci-Hub в социальных сетях → Sci-Hub https://w w URL статьи или журнала, или DOI, или строка для поиска ▶ Помочь проекту ... reduced CD44 expression in CD44+ CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug The CD44+ CD24- breast cancer stem cells were isolated from breast tumors; CD44. .. and Therapy » Volume Original Research Highly Accessed Downregulation of CD44 reduces doxorubicin resistance of CD44+ CD24- breast cancer cells     Abstract Fulltext Metrics Get Permission... was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug Results: The proliferation of CD44 downregulated CD44+ CD24- breast cancer stem cells was decreased