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Vol 9, No 4, July/August 2001 227 Traumatic muscle contusion is a common cause of soft-tissue injury in virtually all contact sports. In fact, contusion and strain injuries make up approximately 90% of all sports-related injuries. 1,2 Other than strain injuries, contusion caused by impact with a blunt, nonpenetrating object is the most frequent muscle injury. 3 The symptoms of a contusion injury are often nonspecific, and include soreness, pain with active and passive motion, and limited range of motion. Without a straight- forward history of impact to the area, the diagnosis often becomes one of exclusion. Many contusion injuries go unreported and untreated. Healing of these injuries is a complex phenomenon depending on multiple factors, both within and outside the control of the clinician. No universally accepted treatment modalities have been developed. Most treatments follow the “RICE” principle (rest, immobilization, cold, and elevation) at least in the short term, but clinicians differ as to the best long-term treatment. Common sites of contusion injuries include the anterior, poste- rior, and lateral aspects of the thigh and the upper arm in the region of the brachialis (causing “tackler’s exostosis”). Contusions in the area of the quadriceps and the lateral thigh may cause excessive hematoma to accumulate due to the large potential space. 4 A frequent complication is ossification of the hematoma in response to mechanisms that are as yet unclear. It is generally felt that injury sufficient to cause proliferative repair is essential to the development of myositis ossificans. 5 At the level of the muscle fibers, capillary bleeding and edema can lead to hematoma formation and can cause compartment syn- drome in areas in which the volume is limited by the fascial envelope. There are a number of common types of muscle injuries (Table 1). Several excellent reviews of muscle strain injuries 2,6,7 and of exercise- induced muscle injury 8-10 have ap- peared in the recent literature, but there have been none that summarize the body of literature dedicated to muscle contusion injury. There are, however, a large number of studies, especially those reporting on animal research, that detail the mechanisms of injury, the natural history, and the effects of various treatment modalities. The lessons learned in the laboratory can now begin to be translated to the care of the injured patient. Dr. Beiner is Resident, Department of Ortho- paedics and Rehabilitation, Yale University School of Medicine, New Haven, Conn. Dr. Jokl is Vice Chairman and Chief, Section of Sports Medicine, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine. Reprint requests: Dr. Jokl, Yale University School of Medicine, Suite 600, 1 Long Wharf Drive, New Haven, CT 06511. Copyright 2001 by the American Academy of Orthopaedic Surgeons. Abstract Muscle contusion is second only to strain as the leading cause of morbidity from sports-related injuries. Severity depends on the site of impact, the activation status of the muscles involved, the age of the patient, and the presence of fatigue. The diagnosis has traditionally been one of clinical judgment; however, newer modalities, including ultrasonography, magnetic resonance imaging, and spectroscopy, are becoming increasingly important in both identifying and delineating the extent of injury. Although controlled clinical studies are scarce, animal research into muscle contusions has allowed the description of the natural healing process, which involves a complex balance between muscle repair, regeneration, and scar-tissue formation. Studies are being performed to evaluate the effects of anti-inflammatory medications, corticosteroids, operative repair, and exercise protocols. Prevention and treatment of complications such as myositis ossificans have also been stressed, but recognition may improve the outcome of these ubiquitous injuries. J Am Acad Orthop Surg 2001;9:227-237 Muscle Contusion Injuries: Current Treatment Options John M. Beiner, MD, and Peter Jokl, MD Mechanisms of Injury The clinical entity of a muscle contusion injury is most often seen after a direct blow to an extremity. In football, this frequently occurs in the anterior, medial, or lateral thigh in the area of the muscle belly of the quadriceps femoris. 11 The greatest number of quadriceps contusions in one study occurred in tackle football, although the percentage of injuries was higher in rugby, karate, and judo. 11 In soccer, after the widespread adoption of the use of shin guards, the thigh is now the most commonly injured area as well. However, these injuries have been reported in virtually all contact sports. The injury is associated with pain and swelling, a decreased range of motion of joints spanned by the injured muscles, and occasionally a permanent palpable mass. 11 In animal studies, at a microstructural level, contusion injury usually causes a partial rupture of the muscle, capillary rupture, and infiltrative bleeding, leading to hematoma formation within the developing gap and around the intact muscle fibers, edema, and inflammation. 12 De- spite all these changes, some functional capacity usually remains in the affected muscle. 13,14 The architecture of the damaged muscle bed is a mix of disrupted muscle cells and collagen connective tissue. The healing process is a delicate balance between the formation of scar tissue by fibroblasts and the regeneration of normal muscle by migrating myoblasts. Injury Severity Information regarding the structural, cellular, and biochemical events in contusion injury is essential to the rational application of sports therapy. Studying these injuries is difficult, however, because of the inherent variability in severity. In contrast, the research setting provides a means to control many of the confounding variables involved in muscle contusion research. Models of contusion that have been developed use spring- loaded hammers, crushing hemostat forceps, reflex hammers, and a vari- ety of other devices to cause single or multiple contusion injuries ranging from the mild to the severe in rodents and nonhuman primates. Only two, however, have been able to deliver a standardized crush injury. Järvinen and co-workers 15-17 developed a rat model of muscle contusion injury involving the use of a spring-loaded hammer and compared the effects of mobilization and immobilization on the healing process. They found that early mobilization increased the tensile strength of the muscle compared with similarly injured muscles immobilized in a plaster cast. 15-17 Stratton et al 18 used a drop-mass technique that delivers a single blow to muscle to study the effects of therapeutic ultrasound on the injury. A problem common to all of these models, however, is the inability to characterize the injury in terms of force, displacement, energy, and impulse of the impact actually experienced by the target muscle. Crisco et al 19 developed a model to record these variables in the production of a standard, reproducible muscle contusion injury to the rat gastrocnemius-soleus muscle complex. Others have used this same model to observe a standard contusion injury that causes hematoma formation, with disruption of indi- vidual muscle fibers but preserva- tion of others, a brisk inflammatory reaction, and marked interstitial edema. 20 The extrinsic factors that affect injury severity have not been well documented. The debate continues in the sports arena as to whether athletes should “tighten up” before impact during athletic contests in order to minimize injuries. In studies of muscle strain injury, it has been shown that an activated or contracted muscle will absorb more energy and require a much higher force to failure than passively stretched muscle. 2,21 Crisco et al 22 showed that contracted muscle was able to absorb more energy during impact than relaxed muscle. The peak force recorded was less pronounced than that in passively impacted muscle. This is complicated, however, by the fact that the impacted legs were an in vivo composite of skin, muscle, fascia, and bone. Contraction simply stiffened the muscle relative to the bone, allowing protection from injury. Later experiments by Beiner 23 continued the work of Crisco et al 22 and found that the relaxed muscle- bone composite was significantly (P<0.05) stiffer than the contracted muscle-bone composite. This was Muscle Contusion Injuries Journal of the American Academy of Orthopaedic Surgeons 228 Table 1 Common Types and Causes of Muscle Contusion Exercise-induced injury (“delayed onset muscle soreness”) Strain Laceration Traumatic Surgical Vascular Tourniquet Traumatic vascular injury Infectious Bacterial Viral Neurologic Denervation Viral (central or peripheral) Traumatic (central or peripheral) Neuropathic Metabolic Viral Genetic Myopathies due to the fact that on impact some of the bulk of the relaxed muscle parted, concentrating the force of the impacting sphere on part of the muscle near the bone. In contrast, the contracted muscles were able to absorb energy by displacing less, distributing the force over the entire muscle belly, and avoiding severe damage to any one area. Energy absorbed was 10% more than in the relaxed muscle-bone composite (P<0.05). These concepts are illus- trated by Figure 1, showing that two peaks are present for impacts to relaxed muscle, one for initial impact on the muscle and the second as the impactor compresses the remaining muscle and hits the bone. Changing the shape of the impacting surface into a bar rather than a sphere changed the injury slightly, but did not seem to change the overall force-generating capacity of the muscles following injury. To model the effect of constraining hard or soft padding or taping on muscle injury, Beiner 23 analyzed the effects of muscle contraction with exterior constraint (by enclosing the entire leg in a narrow-walled chamber during impact), which limited the extent of the lateral deformation available to the muscle as it absorbed impact. This seemed to cause a much more severe injury. When the muscle was externally constrained during impact, the force-displacement curves of the contracted and relaxed muscle-bone composites were comparable. The injury was 11% greater for constrained muscles in subsequent contractile testing (P<0.05). Constrain- ing the muscle also caused the energy absorbed to increase by approximately 11%, as occurs with contraction. It may be that the muscle could not deform while constrained, resulting in more severe injury. John M. Beiner, MD, and Peter Jokl, MD Vol 9, No 4, July/August 2001 229 Figure 1 Force-displacement behavior of rat gastrocnemius-soleus muscle complex impacted in either the contracted or relaxed state with a drop-mass technique. The constrained muscles were held with walls on either side, limiting their lateral displacement. Constraining and contraction caused the peak forces to be distributed over a broader area, changing the impulse to the muscles. All impact stimulation was at 100 Hz and 70 V, with a 0.1-msec pulse duration and 1.5-sec train duration. Curves are mean ± SD (N = 27). 220 200 180 160 140 120 100 80 220 200 180 160 140 120 100 80 200 180 160 140 120 100 80 60 40 20 0 0 2 4 6 8 10 12 Displacement, mm 200 180 160 140 120 100 80 60 40 20 0 0 2 4 6 8 10 12 Displacement, mm 60 40 20 0 0 2 4 6 8 10 12 Force, N Displacement, mm 60 40 20 0 0 2 4 6 8 10 12 Force, N Displacement, mm 220 Force, N 220 Force, N Nonconstrained Constrained Contracted Relaxed Beiner 23 found that both the status of the activation of the muscle during impact (contracted versus relaxed) and the relative level of external constraint of the muscle predicted the force the muscle could generate in contractile testing. Contracted muscle generated a 10% increased force relative to relaxed muscle (P<0.05), while constrained muscle was weaker by 11%. Clinical correlates to external constraint include design of pads; the relative volume of muscle that is protected by an enclosing hard plas- tic pad may affect how the muscle absorbs the energy of impact. More research is needed in this area before further recommendations can be made in the sports arena regarding equipment design and protective measures for impact. Fatigue has been shown to affect the ability of stretched muscle to withstand injury, 24 as has temperature 25 ; no similar studies have been performed in the setting of contusion injury. Fatigue lessens the ability of a muscle to fully contract, and contraction seems to protect the muscle from injury, but a direct causal relationship has yet to be established. Physiologists have long known that muscles operate best within a certain temperature range. Warm-up before exertion thus has obvious benefits, but a direct relationship between overheating, fatigue, and injury has not been delineated. Muscles in young rats seem to undergo more intense inflammation, with more proliferation of fibroblasts and production of collagen, than old muscles. 26 Young muscles also heal more rapidly and more completely, suggesting the greater power of young regenerating tissue to respond to injury. Diagnosis The clinical diagnosis of contusion injury is often fairly direct (Fig. 2). The patient experiences local swelling, tenderness, pain, and impaired athletic performance. The extent and type of soft-tissue injury, however, are less readily established. Many researchers have attempted to demonstrate the usefulness of imaging in determining the extent and the healing of contusion injury. Ultrasound has been used success- fully to distinguish pervasive swelling and edema from a localized, cir- cumscribed hematoma. 27 It has also been advocated as a noninvasive aid in determining when to consider surgical evacuation of the hematoma and when to choose the less aggressive compression and early mobilization. Magnetic resonance (MR) imaging has also been used to evaluate patients with the clinical signs and symptoms of contusion injury, but its role is currently limited to selected patients. It is most useful in the sub- acute setting when a definite history of trauma is lacking. 28 Although the clinical uses of MR imaging in following contusion injury are less well defined, it has been shown to be more sensitive than computed to- mography (CT) for the detection of hemorrhage. 29 It may allow sequen- tial follow-up during healing, and the addition of contrast material may enhance injury recognition and evaluation of the extent of injury. 30 Muscle Contusion Injuries Journal of the American Academy of Orthopaedic Surgeons 230 Consider operative repair Early mobilization with passive range of motion, stretching Pain-free passive range of motion Consider myositis ossificans Immobilize in neutral position (no tension on repair) Contusion with muscle tear (gap, fascial tear, or avulsion detected by physical examination or imaging) Contusion without muscle tear Immobilize muscle in stretched position for 24 hours, NSAIDs 24 to 48 hours, avoid steroids Assess severity of muscle contusion injury: • Physical examination (range of motion, palpable gap) • Ultrasound, magnetic resonance imaging Progress to concentric active range of motion and strengthening to tolerance Prolonged painful range of motion, swelling, erythema Functional rehabilitation with graded increased eccentric range of motion Figure 2 Algorithm for the evaluation and treatment of muscle contusion injuries. NSAIDs = nonsteroidal anti-inflammatory drugs. Standard MR imaging provides information regarding the site and extent of injury, but MR spectroscopy, in limited use for some years, can also be used to estimate the ratio of inorganic phosphate to phosphocrea- tine, which reflects the metabolic response to muscle injury. 31 The Healing Process Fisher et al 32 gave a detailed account of the ultrastructural events after muscle contusion injury to the rat gastrocnemius muscle. Figure 3 shows the histologic appearance of normal healing of contused muscle. Muscle consists primarily of tissue derived from cells of two separate and distinct lineages: fibroblasts and myoblasts. After injury, the damaged segments show gross tear- ing and degeneration. A large number of mononuclear cells are drawn to the injured area, with an intense inflammatory response and interstitial edema. By 24 to 48 hours, there is an increase in the number of sar- colemmal nuclei, with activation and proliferation of the satellite myogenic cells lying between the basal lamina and the plasma mem- brane of the muscle fibers. By day 3, regenerating muscle cells display central nuclei and reorganizing sar- comeres. By day 6, focal interstitial collagen formation suggests mini- mal to mild scar formation. After 14 to 21 days, no residual evidence of the injury is apparent. Lehto and Järvinen 33 described the important role played by the basal lamina in the regeneration of muscle. If it is intact, it acts as a bar- rier to fibroblast infiltration and as a scaffold for myoblast proliferation. With more severe injuries, when the gap in the damaged muscle fibers is larger, the ruptured gap can be filled with proliferating granulation tissue and later by a connective tissue scar. 16,34 As described by Lehto and Järvinen, 33 healing of injuries is dependent on several factors: damage to the neural input, vascular ingrowth, oxygen supply, the rate John M. Beiner, MD, and Peter Jokl, MD Vol 9, No 4, July/August 2001 231 Figure 3 Histologic sections of muscle tissue after contusion injury (hematoxylin-eosin; original magnification ×200). A, At day 2, hematoma is evident, as well as a brisk inflammatory reaction with marked interstitial edema. B, At day 7, there is evidence of removal of the necrotic tissue, disper- sal of the inflammatory cells, and infiltration. C, At day 14, the tissue looks very similar to normal muscle, with clearing of necrotic tissue, regeneration of fibers, and relatively normal tissue architecture. (Reproduced with permission from Beiner JM, Jokl P, Cholewicki J, Panjabi MM: The effect of anabolic steroids and corticosteroids on healing of muscle contusion injury. Am J Sports Med 1999;27:2-9.) C A B and geography of myoblast fusion to myotubes, the collagen cross- linking, and the overall race between regenerating myoblastic cell infiltration and granulation and scar formation. Some, but not total, re- modeling occurs later. Histologic staining with vimentin provides qualitative and quantitative markers for mesenchyma-derived cells. Trichrome staining tracks collagen. Crisco et al 19 used markers for protein and collagen formation to study the healing after contusion injury in a rat model. At day 0 after contusion injury, no vimentin was noted, but inflammatory cells were present. At day 2 of healing, an intense inflammatory response with phagocytosis of necrotic muscle fibers and supporting tissue was noted. The basement membranes were intact, and spindle-shaped fibroblasts were present in moderate numbers. Trichrome stains demonstrated the presence of collagenous material beginning to form in the area. Slight vimentin activity was noted at the periphery, indicating differentiation of myoblast precursor cells from satellite stem cells (Fig. 4, A). At day 7 of healing, trichrome staining of collagen showed increased scarring in the central areas where the muscle architecture was destroyed. A marked increase in vimentin staining was noted, localized to the center as well as to the periphery at this time point (Fig. 4, B). By 24 days after injury, there was no difference between damaged muscles and control muscles with regard to the staining pat- terns. Some scar tissue was still evident, however, in the most severely damaged muscle. Healing in the rat model is recognized as more accelerated than in humans, but just how much faster is a matter of controversy. Certainly there are phylogenetic differences between animals and humans, and healing in humans is usually shown to be slower and less complete than in an animal model. Muscle Contusion Injuries Journal of the American Academy of Orthopaedic Surgeons 232 Figure 4 A, Histologic sections at day 2 after injury (original magnification ×200). Top, Trichrome stain shows intense inflammatory response with phagocytosis. Intact basement membranes are seen as thin lines stained blue. Bottom, With vimentin stain, slight activity (red) is noted at the periphery of the injury adjacent to the intact fibers (IF). B, Histologic sections at day 7 after injury (original magnification ×200). Top, With trichrome staining, collagenous (blue) and proteinaceous (red) ground substance can be differentiated. Bottom, Intense vimentin activity (red) is noted at the periphery of the injury and extends centrally. (Reproduced with permission from Crisco JJ, Jokl P, Heinen GT, Connell MD, Panjabi MM: A muscle contusion injury model: Biomechanics, physiology, and histology. Am J Sports Med 1994;22:702-710.) A B IF Clinically, studies of the healing of contusion injuries are necessarily influenced by the type of treatment used, whether it be immobilization, activity ad libitum, or some other modality. Animal studies have been conducted in an attempt to define the clinical course of thigh contusions. In a sheep model, the injury caused extensive scarring, with periosteal bone formation and heterotopic bone formation in 17% of the legs within 3 weeks to 3 months after trauma and replacement of muscle tissue by intramembranous ossification within scar tissue. 12 Several earlier studies reported no ossification, despite extensive ne- crosis, regeneration, and granulation tissue. Human studies of contusion injuries are limited. The most important of these are the West Point studies of quadriceps femoris contusions. 4,11 The initial study deter- mined a rationale for treatment and therapy with an emphasis on achieving full extension, with immobilization in extension during rest. 4 Later, the researchers found that normal flexion was the variable that was slowest to return, and this lack of flexion prolonged disability after pain resolved. 11 They subsequently modified their proto- col to immobilize the muscle in a stretched position, with early motion emphasizing flexion. They classified injuries by range of motion at 12 to 24 hours after injury. Mild injuries were defined as those after which range of motion greater than 90 degrees was possi- ble; moderate, 45 to 90 degrees; and severe, less than 45 degrees. Aver- age disability (defined as inability to participate in full cadet activi- ties) was 13 days for mild contusions, 19 days for moderate injuries, and 21 days for severe injuries. This contrasted with the much longer disability (up to 72 days) with the previous treatment pro- tocol. Myositis Ossificans Myositis ossificans has long been recognized as a leading complication of muscle contusion injury. Although certain regions are more prone to the development of myositis, such as the quadriceps and brachialis, the mechanisms have not been clearly established. Similar to the development of heterotopic ossification after surgical dissection, the factors that make some patients prone to this complication are unclear. Myositis ossificans was a complication of 9% of the contusion injuries in the West Point studies, and was found to be related to the initial grade of injury (based on range of motion). 4,11 Several different kinds of myositis have been identified. In the stalk type, there is a thin stalk of bone connecting the ossified muscle to the underlying bone. In the periosteal type, there is a broad-based region of ossification in contact with the underlying bone. In the third type, the ossified muscle is not connected to the underlying bone at all, but rather seems to derive entirely from the affected muscle. Within 3 weeks after injury, os- teoblastic activity can be detected with bone scanning. To minimize the risk of recurrence, surgical removal should be delayed until the bone has matured (usually after 6 months to 1 year) and no longer shows increased uptake on a bone scan. Treatment A general approach to the treatment of muscle contusion injuries is shown in Figure 2. Operative Treatment Traditionally, muscle contusion injuries have been treated nonoper- atively. Many surgeons have reported their anecdotal sense that in the presence of hematoma and a palpable defect in the muscle belly, it is difficult to suture the muscle together, as there are frequently no fascial ends to close, and muscle fibers are poorly reapproximated. However, recent animal studies have provided increasing evidence that in the setting of a contusion injury that causes a spatial defect in the muscle belly, suturing with large absorbable sutures through the thick substance of the muscle does decrease the distance between the lacerated edges, allowing faster healing. 27 Following the healing of rat gastrocnemius muscles with MR imaging, Mellerowicz et al 30 found that “suture of the divided muscles resulted in more rapid healing without major defects.” In a mouse model, suturing of the cut ends of the muscle resulted in “better healing of the injured muscle and prevented the development of deep scar tissue in the lacerated muscle.” 35 The authors found that tetanic strength was 81% of that in control muscles for sutured muscles, 35% for untreated lacerated muscles, and 18% for immobilized muscles at 1 month after injury. They recommended repair with a modified Kessler stitch. Another study stressed the need for exercise after laceration of muscle. The authors found that the regenerating muscle-scar composite eventually regained almost complete (96%) resistance to stress, but the surrounding area of atrophied muscle made the muscle unit as a whole weaker when immobilized. They did not perform contractile testing. 36 Human studies in this area are lacking. Immobilization Versus Early Mobilization Immobilization was long used as part of the rehabilitation of muscle contusion injuries. The complications of immobilization, even for short periods of time, including rerupture, muscle atrophy, joint stiff- John M. Beiner, MD, and Peter Jokl, MD Vol 9, No 4, July/August 2001 233 ness, and a high incidence of myositis ossificans, prompted studies of early mobilization. In a study com- paring mobilization and immobilization after contusion injury in rats, the immobilized legs lost 30% of their weight, but no such atrophy was observed in the mobilized legs. In addition, delayed contraction and maturation of the fibrous scar were noted in the third week after injury. 16 These effects occurred even after only 2 to 5 days of immobilization. Studying load-deformation curves when pulling injured muscle to failure after contusion injury, Järvinen 13 found that the muscles mobilized on a treadmill failed at a significantly greater force than the immobilized muscles. Immediately after injury, the muscles pulled to failure at approximately 20% of the force needed to cause contralateral nonin- jured muscles to fail. After 1 week of treatment, the decrease in tensile stiffness for immobilized muscles (compared with intact control muscles) averaged 33%. In contrast, mobilized muscles had healed to within 11% of the force to failure of control muscles. The mobilized muscles recovered tensile strength more quickly and more completely than the muscles treated with “no specific treatment” (i.e., cage activity ad libitum). After 3 weeks of re- training, these levels had not nor- malized to those of muscles mobilized immediately after injury. The authors concluded that early mobilization restored functional capacity of healing muscle earlier than immobilization. Lehto et al 34 found that immobilization after injury accelerated granulation tissue production. However, they also found that if continued too long, it can “lead to contraction of the scar and to poor structural orga- nization of the components of regenerating muscle and scar tissue.” These conclusions were based on the characteristics revealed by histo- chemical staining, measurement of tensile properties, and the gross appearance of the muscles during healing. The authors concluded that a certain period of immobilization (5 days for rats) is beneficial to allow subsequent mobilization without causing further trauma to the healing tissue. In another study, Järvinen 13 eval- uated four exercise regimens imple- mented after contusion injury in rats, using the local concentrations of leukocytes, erythrocytes, and collagen fibers in the injured muscle as a way of measuring the rate of resolu- tion of the contusion. It was found that running immediately after injury is the regimen of choice, because of more rapid disappearance of the injury than with the delayed or no-exercise regimens. Running was also better than swimming. Capillary density after injury has been found to transiently decrease after immobilization of muscle. Similar trends have evolved in the treatment of humans. Jackson and Feagin 4 developed a treatment strategy for West Point cadets who suffered contusion injuries to the quadriceps muscle. They initially emphasized rest of the injured leg in extension and early restoration of full knee extension. With this treatment, the trainers and therapists noted that “normal flexion was the slowest parameter to return,” causing prolonged disability. A later study 11 emphasized immobilization in muscle tension (flexion for quadriceps contusion) for a short period of time (24 hours for mild injuries, 48 hours for severe injuries), followed by well-leg and gravity- assisted motion as soon as pain re- lief permits. Patients are advanced to functional rehabilitation when 120 degrees of pain-free active knee motion is achieved. These studies have led to the now-common clinical practice of immobilization only in the period immediately after injury to limit hematoma formation, followed by early mobilization. Cryotherapy The most common treatment of musculoskeletal injuries is the application of ice. One group tested the hypothesis that cryotherapy after contusion injury is effective because it reduces microvascular perfusion and subsequent edema formation. 37 The authors found that cryotherapy caused vasoconstriction and decreased perfusion transiently, but found no long-term microvascular effects. Thus, the therapeutic win- dow of opportunity is relatively small for the effects of cryotherapy. Pharmacologic Treatment Inflammation is thought to be beneficial in attracting reparative cells as a part of muscle healing, allowing clearance of nonviable tissues and preventing scar formation. However, it is also thought by some to be the cause of continued pain and swelling that may limit mobility and prevent healing. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed by physi- cians dealing with musculoskeletal injury. Once again, animal studies provide some information. Fisher et al 38 studied the effect of systemic inhibition of prostaglandin synthesis (by naproxen) on muscle protein balance after contusion injury in the rat. Their findings were similar to those in many of the early studies of muscle contusion injury, in that normal muscle healing for the first 3 days was characterized by a marked catabolic response, followed by muscle protein repletion for several weeks. Inhibition of prostaglandin synthesis significantly (P<0.05) reduced the catabolic loss of muscle protein seen locally and peripheral to the injury site. 38 In another well-designed study, Järvinen et al 39 used their model to test the effects of two different NSAIDs as well as hydrocortisone on the healing of contusion injuries. Histologic, enzyme, and mechanical measurements were recorded. Muscle Contusion Injuries Journal of the American Academy of Orthopaedic Surgeons 234 They found that the drugs all significantly (P<0.05) decreased the acute inflammation, but also caused a slight decrease in tensile properties in the longer term. They noted delayed elimination of hematoma and necrotic tissue and retardation of muscle regeneration in the hydrocortisone group but not in the NSAID groups. Similar studies have been performed with the use of other muscle injury paradigms. In the study by Mishra et al, 40 rabbit muscles were subjected to a repetitive exercise program and treated with flurbipro- fen. The authors reported that the treatment group showed a “more complete functional recovery than the untreated controls at 3 and 7 days but had a deficit in torque and force generation at 28 days.” Nonsteroidal anti-inflammatory drugs have not been studied in relation to healing of muscle contusion injuries in humans. However, the data on NSAIDs in strain injuries are conflicting, and there are no definitive conclusions as to their efficacy or long-term effects on muscle regeneration. Corticosteroids are also used by some in the treatment of muscle injuries. Using the contusion injury model, Beiner et al 20 studied the effect of systemic (depot intramus- cular) treatment with a corticosteroid (methylprednisolone) versus that with an anabolic steroid (nan- drolone). With corticosteroid treatment, there was a marked lack of the initial inflammation at the contusion site, with increased force- generating capacity in those muscles during the early phases. Later, however, the corticosteroid-treated muscles demonstrated a retardation of the normal healing response, with delayed clearing of necrotic tissue and muscle regeneration. Although comparable to the doses used in other animal studies, the doses of corticosteroid were large, and may not simulate accepted doses in human studies. In contrast, the muscles treated with the anabolic steroid demonstrated a robust initial inflammation but proved to have an increased force- generating capacity in the long run, relative to control muscles. Thus, it appears that corticosteroids may have a beneficial effect in the short term on muscle healing but may be detrimental over the longer term, inhibiting the normal muscle regeneration cascade in this animal model. Studies in humans have had conflicting results. In one trial, Levine et al 41 retrospectively reviewed a series of hamstring injuries in Na- tional Football League players and found no adverse effect of injection of corticosteroid directly into the area of hamstring injury. However, these injuries were strain injuries rather than contusions, and no control group was used. Furthermore, the outcome measures were subjec- tive (e.g., pain control, time to return to active status) rather than ob- jective (e.g., isometric strength, time to fatigue). More research is neces- sary to determine whether corticosteroids have a role in treatment of contusion injuries. Other pharmacologic agents have also been studied in the setting of muscle contusion injury. Using the model of blunt contusion injury developed by Crisco et al, 19 one group studied eight growth factors and their effect on healing. They found that three growth factors— fibroblast growth factor (FGF)-beta, insulinlike growth factor-I, and nerve growth factor—enhanced myoblast proliferation and differentiation in vitro and improved the healing of the injured muscle in vivo. 42 Injection of the growth factors also led to enhanced fast-twitch and tetanic strength of the contused muscles 15 days after injury. The study suggested that gene therapy, in the form of myoblast transplanta- tion into injured tissue, might be used to stimulate persistent expres- sion of growth factors capable of promoting the recovery of skeletal muscle after injury. Another group studied FGF-6 and its up-regulation after skeletal muscle injury in mice. 43 Strains of mice lacking the gene for FGF-6 show a severe regeneration defect following injury, with fibrosis and myotube degeneration. They concluded that FGF-6 is a “critical com- ponent of the muscle regeneration machinery in mammals, possibly by stimulating or activating satellite cells.” Summary Muscle contusion injuries are common events in the athletic world. Various diagnostic modalities are becoming more commonly used to establish the nature and extent of the lesions. The factors influencing the severity of such injuries are becoming delineated, as are the microstructural events following injury. As more and more clinical research is done, several trends in treatment are evolving. Long-term immobilization is to be avoided in favor of a more rapid return to motion and exercise. Nonsteroidal anti-inflammatory drugs, similar to corticosteroids, may have initial beneficial effects, but their long- term effects on muscle healing and regeneration remain to be established. Other medications, including growth factors and some steroids with anabolic effects, may prove beneficial to the healing process. Animal studies indicate that perhaps surgeons should give more thought to open repair of these muscle injuries, as it appears that, as is the case with nerve tissue, reapproximating the damaged ends may allow the balance between scar formation and tissue regeneration to shift toward a more useful reparative process. John M. Beiner, MD, and Peter Jokl, MD Vol 9, No 4, July/August 2001 235 References 1. Canale ST, Cantler ED Jr, Sisk TD, Freeman BL III: A chronicle of injuries of an American intercollegiate football team. Am J Sports Med 1981;9:384-389. 2. Garrett WE Jr: Muscle strain injuries: Clinical and basic aspects. Med Sci Sports Exerc 1990;22:436-443. 3. 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