Bài giảng chuyển hóa các chất - Chuyển Hóa Lipid part 4 ppt

2.1. 2.1.  oxy ho¸ Acid bÐooxy ho¸ Acid bÐo   Oxy ho¸ AB no, C ch½nOxy ho¸ AB no, C ch½n X¶y ra trong ty thÓ cña tÕ bµo X¶y ra trong ty thÓ cña tÕ bµo + Ho¹t ho¸ AB: + Ho¹t ho¸ AB: ABAB + CoA + ATP + CoA + ATP Acyl CoA + AMP + PPi+ AMP + PPi Ii. chuyÓn ho¸ acid bÐoIi. chuyÓn ho¸ acid bÐo Acyl CoA SyntethaseAcyl CoA Syntethase AMP + PPi R-CH 2 -CH 2 -CH 2 -COOH Acid bÐo (n ch½n, no) Acyl-CoASyntetase HS-CoA ATP   Acyl-CoA R-CH 2 -CH 2 -CH 2 -CO~S-CoA + VËn chuyÓn a.bÐo tõ bµo t¬ng + VËn chuyÓn a.bÐo tõ bµo t¬ng  ty thÓty thÓ Acyl CoAAcyl CoA + Carnitin + Carnitin  AAcylcyl CarnitinCarnitin AcylAcyl Carnitin chuyÓn tõ bµo t¬ng Carnitin chuyÓn tõ bµo t¬ng  ty thÓ ty thÓ Gi¶i phãng Carnitin Gi¶i phãng Carnitin  AcylCoAAcylCoA VËn chuyÓn acid bÐo vµo trong ty thÓ theo hÖ thèng vËn chuyÓn acyl-carnitin/carnitin + +  oxy ho¸ AcylCoA (nC) trong ty thÓ qua 4 ph¶n øngoxy ho¸ AcylCoA (nC) trong ty thÓ qua 4 ph¶n øng 11. . Khö hydro lÇn 1 t¹oKhö hydro lÇn 1 t¹o   Dehydro Dehydro Acyl CoAAcyl CoA 2. Hîp H2. Hîp H 22 O t¹o O t¹o  Hydroxy Hydroxy Acyl CoAAcyl CoA 3. Khö 3. Khö hydro lÇnhydro lÇn 2 t¹o 2 t¹o  Ceto Ceto Acyl CoA Acyl CoA 4. Ph©n c¾t 4. Ph©n c¾t  Ceto Ceto Acyl CoA Acyl CoA  Acyl CoA (nAcyl CoA (n 2)C + 2)C + Acetyl CoAAcetyl CoA (2C) (2C) ThiolaseThiolase Acyl CoA (nAcyl CoA (n 2)C 2)C > 1, 2, 3, 4 > 1, 2, 3, 4 >>………………. . > Acyl CoA (4C) > Acyl CoA (4C) Acyl CoA (4C)Acyl CoA (4C) => 2 Acetyl CoA=> 2 Acetyl CoA S¶n phÈm thu ®îc: Acetyl CoA + Vßng -Oxy ho¸ R-CH 2 -CH 2 -CH 2 -CO~S-CoA R-CH 2 -CH=CH-CO~CoA R-CH 2 -CH-CH 2 -CO~S.CoA OH R-CH 2 -C-CH 2 -CO~S.CoA O R-CH 2 -CO~S-CoA + CH 3 CO~S-CoA Acyl-CoA DH Acyl-CoA (n-2)C Acetyl-CoA CoA.HS -HydroxyacylCoA DH Enoyl Hydrase FAD + FADH + H + HOH NAD + NADH + H + -CetoAcyl-CoA -HydroxyAcyl-CoA ,-DehydroAcyl-CoA ( Enoyl-CoA) Thiolase Acyl-CoA  (1) (2) (3) (4) Vßng xo¾n LynenVßng xo¾n Lynen Feodor Lynen (§øc) 1911-1979 Gi¶i thëng Nobel 1964Gi¶i thëng Nobel 1964 . ho¸ R-CH 2 -CH 2 -CH 2 -CO~S-CoA R-CH 2 -CH=CH-CO~CoA R-CH 2 -CH-CH 2 -CO~S.CoA OH R-CH 2 -C-CH 2 -CO~S.CoA O R-CH 2 -CO~S-CoA + CH 3 CO~S-CoA Acyl-CoA DH Acyl-CoA (n-2)C Acetyl-CoA CoA.HS -HydroxyacylCoA. SyntethaseAcyl CoA Syntethase AMP + PPi R-CH 2 -CH 2 -CH 2 -COOH Acid bÐo (n ch½n, no) Acyl-CoASyntetase HS-CoA ATP   Acyl-CoA R-CH 2 -CH 2 -CH 2 -CO~S-CoA + VËn chuyÓn a.bÐo tõ bµo t¬ng +. H + -CetoAcyl-CoA -HydroxyAcyl-CoA ,-DehydroAcyl-CoA ( Enoyl-CoA) Thiolase Acyl-CoA  (1) (2) (3) (4) Vßng xo¾n LynenVßng xo¾n Lynen Feodor Lynen (§øc) 191 1-1 979 Gi¶i thëng Nobel 1964Gi¶i