NEW FINDINGS OF THE THESIS Thesis title Study on chemical constituents and biological activities of two specie Markhamia stipulata var canaenses V S Dang and Stereospermum binhchaunesis V S Dang of Bi[.]
NEW FINDINGS OF THE THESIS Thesis title: Study on chemical constituents and biological activities of two specie Markhamia stipulata var canaenses V.S Dang and Stereospermum binhchaunesis V.S Dang of Bignoniaceae Code: 9440117 Major: Chemistry of natural compounds Name: Ngô Trọng Nghĩa Year: 2016 -2020 Supervisors : Assoc Prof Dr Mai Đinh Tri, Assoc Prof Dr Tran Cong Luan Imlementing institution : Graduate University of Science and Technology – Viet Nam Academy of Science and Technology New findings of the thesis : From the leaves of Markhamia stipulata var canaense V.S Dang has isolated and determined the structure of 17 compounds, including new compounds: Markhacanasin A, Markhacanasin B, Markhacanasin C, epi-Markhacanasin C and Markhasphingolipid A For the first time discovered in the genus Markhamia there is a cycloartane triterpenoid with aglycon part cycloart-24-en triterpen while in Markhamia lutea species cycloart -23-en and cycloart-25-en It was first discovered in the genus Markhamia that contains glycolipid compounds in the form of glycerol derivatives and phytosphingolipid From the leaves of Stereospermum binhchaunesis V.S Dang has isolated and determined the structure of 11 compounds, of which 10 were first isolated from Stereospermum For the first time discovered in the genus Stereospermum has group of flavonoid compounds Evaluated cytotoxic activity of 11 compounds The results showed that there are compounds with cytotoxic activity: Markhacanasin A, 24-epi markhacanasin C, apienin 7-O-β-D-glucopyranoside, 2,3-dihydroxypropyl palmitate Espcially, the new compound Markhacanasin A has cytotoxic activity on all cell lines of breast cancer (MCF-7), cervical cancer (HeLa), liver cancer (Hep G2), lung cancer (NCI) H460), blood cancer (Jurkat), with IC50, respectively: 16.51 ± 0.22, 29.55 ± 1.64, 25.26 ± 1.06, 24.21 ± 0.38, 14.72 ± 0.38 (µg/mL) Signature of supervisor Assoc Prof Dr Mai Đinh Tri Signature of PhD student