Nghiên cứu các hiệu ứng nhiệt của viba lên cơ thể sống

T*P CHf KHOA HQC & C N G NGIlg C A C TRUING DA' "QC K i THU^T * S6 89-2012 NGHIEN ClTU CkC H l f U tTNG NHI$T CUA VI BA L^N CO THE S N G STUDY OF THERMAL EFFECTS OF MICROWAVE ON LIVING TISSUE Mai HQ-u Thudn, Nguyin Tnr&ng Luy^n, Nguyin Tr(mg Anh Nguyin Trgng Luu Trudng Dgi hgc Bdch khoa Hd Ngi Binh viin Tif Qudn dgi Nhan ngfiy 06 thing 12 nSm 2011, c h i p nh(in dfliig 10 thfing nfim 2012 TOM TAT Stic xg Viba dS dugc nghidn cdu vd ung dgng Id- rit Idu Tuy nhiin tdc dgng vd hiiu Ong cOa nd ddi vdi CO thi sdng vin cdn nhiiu vin di chua sdng ti Tuang tdc cua buc xa diin tu- (BXDT) vdi khdi chit duac xdc dinh d$c trugng bdi chOn photon vd sd tdm chuc ndng N' (Sd tdm chdc ning bdng sd diin (i> hogt tinh hip thg photon vd chuyin ddi Idn tr^ng thdi kich thich) Vdi gid thiit mdi tdm chuc ndng cd mit diin tu hogt llnh thi N' = N^ ~ nv/^ ~ n^(uT) Cho biit sd tdm chuc ndng bi cuOng buc Idn trgng thdi kich thich phg thudc rit mgnh vdo mit di photon cd mdt tong miu chit dd Hi qud cda qud trinh tuang tdc dd Id hiiu ung nhiit vd phi nhiit ciia BXDT vdt khdi chit [1] &ng dgng cua hiiu ung nhidt vd phi nhiit duac chung tdi da vd dang nghiin cdv vd Ong dgng trxjngyti Liiu tmng binh: WE 2450MHx P 20^0W.f 10+30phOthodc WE:915MHz P 40W-GOW t: 20^0 phut gdy tdng nhidt td chCic 4(fc - 42°C cd tdc dgng tdng tuin hodn chuyin hda chdng sung vidn Vai cao c6 cdng suit nhu WE -2450MHZ- P30+40W t 30^0 phut gay tdng nhi$t td chuc 43°C T- 45°C Idm co mgch vd tdc mgch gdy hoai tu ti chuc cue bd DOng diiu tn una thu V&I Cdc cdng suit trdn v&i thai gian kdo ddi s§ gdy ndn mdt sd hi$u ung khdng tot cho ca the nhu (thay ddi mach, rdi loan chuc nang thin kinh, mdu ) Chinh vl vdy phdi nghidn cuu ky tuong tdc cOa BXDT vdi cac hieu ung sinh hgc ca thi sdng vd liiu lugng (cdng suit, thdi gian) phu hap di han chi mat tdc hai cua BXDT ABSTRACT There are several unclear issues on the interaction and effect of HF radiation living body The interaction between the microwave and the soft material is detennined by the quantum behavior of the HF photon beam and the concerning functional centers of the soff matenal Assuming each functional center has one active electron and under the HF action this electron absorbs a photon and translates to the excited state, so the number of the functional centers to be influence is N' = Nu ~ nv/"' ~ r? (u, T) that strongly depends on the HF photon density in the sample This interaction process can lead to the thermal and/or nonthermal effects of the micro in soft materials We have systematically studied and applied these effects in medical therapy With the average doses a) frequency WE 2450 MHz power P = 20-^ SOW and treatment duration = 10*30 minutes; orb) WE 915 MHz P = 40-60Wand\ = 20^40 minutes the thermal effect increases the temperature of the tissue to 40 - 42 °C resulting in the enhancement of blood circulation, metabolism and inflammation against capability- A high dose such as WE 2450MHz P = 30 -40 W and t = 30 - 40 minutes causes a raise of temperature to 42 * 45 °C which shnnks and blocks btood vessels, resulting in gangrene of the local tissue This dose is used effectively in cancer treatment However, prolong using such doses will cause negative effects to occur like change of the vessels and functional disorder of the nervous system and blood Therefore, it is of great importance to perform systematically and thoroughly study of the bio-effects of the microware on the living tissues in order to find out the appropnate doses and method preventing the harms C O SO" LY T H U Y E T , ^ Ban chat va ca ehe tuong tae BXDT vai Organisms) Dien tir hoat tinh ed vai trd quyet dinh su tao cic lien ket va cau triic co ^ ^ ^-^ ^ ^ : ^|^^, ^^-^ ^^ ^^^^ ^^^ j ^ , ^ ^ g ^ ^ khoi chat ^^^ ^^ ^^-^^ ^^^^^ ^.^^ ^Q•^^ chiing cimg dong vai tro Khdi chat la khdi kit hop vT md gdm cac nguyen tir cd tuong lac manh me vdi nhau, tao nen cae vat lieu va eo thi (Materials and quyit dinh cac tucmg tac giim khdi chdt vdi cac nhan to ben ngoai, nhat la vdi cac photon (hat co ban cua BXDT) Ban chat cita Urang tac ciia TAP Clll KHOA Hpc & C6NG NGHf cAc TRUdNG 0^1 HQC K^THUi^T * S6 89-2012 BXDT vdi kh6l ch4t Ifi tirong tic giOa photon vdi electron, dd chfnh Ifi dfng lye kfch thfch ho^c lim biin d6i cfic lifin kit khfii chit dSn din sy thay dii ciu tnjc vfi ho^t tfnh ciin kh6i chit Qufi trinh tuong tfic dd xiy trudc hit vfi chd yiu d tfim ho?t tfnh ciia khii chit (m5i lim ho^l tfnh chda mft hoQc mft vii difn tir ho^t tinh) Mft df tfim chdc nfing cic mSu rfin tinh thi thudng khdng vugt qufi lO'Vgram, cdn Irong cic mSu chdl CO thi sing thudng chi vio eft lO" +10'*/gram the trgng Di dfinh gifi hifu qui luong lic cCia BXDT vdi khii chit ta cd thi cfin cd vio s6 tfim chiic nfing N* ciia mSu chit dd bj cuftng biic Ifin ir^ng thii kich thfch mft don vj thdi gian) Vdi gifi thiit mSi tfim chdc nfing cd mft difn tli hofil ttnh thi theo difn lir hgc lugng Id: N*=N,i~nw'"*'~n(uT) Trong dd w"*' Ifi xfic xuit chuyin ddi lugng tu ciia tim ho^t linh (tue Ifi ciia difn tu ho^l linh d tfim) Hf thiic tren cho thiy si tfim chdc nfing bj cudng biic len tr9ng Ihfii kfch thieh phy thufc rat m^h phy thufc binh phucmg vio mft df photon cd m$t mSu chit dd Cac electron khdng the luu l^i d ir^ng thii kfch thich lau mfi chi sau mgt khoang thdi gian rit'ngfin phii chuyen ve tr^ng thai co ban ho$c mgt mde thap han Qui trinh chuyen ddi cd the dugc thyc hifn bfing eieh phat mft photon hofic trao l9i nfing lugng cho m^ng (tire la truyen nhift cho m^ng), hofic lim bien ddi cau true ciia trgng thii chuc nfing vi mang cau true Tuy theo U^g thii epng hudng tir ciia BXDT vi hf difn tir phoi iri eiia tfim chirc nfing theo dieu kifn AE = hv (trong dd AE li khoang cich nfing lugng giQa hai muc chuyen ddi ciia tam chue nfing vdn cd va hv la nfing lugng photon chi tin so v ciia BXDT quyet djnh can duge lya ehpn thieh hgp mft dp ddng photon (do cdng suit ciia BXDT quyet djnh), thdi gian hoi phyc ciia eleetrong hogl tinh ciia tam chiic nang KC va thdi gian tac dyng eiia BXDT sC cd cae he qua sau day: + Hf qua 1: Phat birc x? difn tir (photon) ^ nguyen ly lazer + Hf qufi 2: (Hifu img nhift) Trao nfing lugng cho m^ng dudi d^ng nhifl => dao dfng m^ng tfing -=> lim tfing nhift khii chit + Hf qufi (hifu img phi nhift) Lam biin dj lifin kit vfi ciu trde lim chirc nfing vfi KC Bien dj ciu iruc chfnh Ifi nguyfin nhfin gfiy nfin hogt tfnh ung thu [1],(5],I6J D I TU'ONG VA PHU'DNG PHAP NGHlfeNCO'U Dii tugng nhifin cAu li 16 thd vfi 35 bfnh nhin diiu trj t^i b ^ vifn 108 vfi 35 bfnh vifn K Hi Nfi Phuong phip + Xfiy dgng hf thing chieu xg: bao gim miy phit sdng r4-l 51 dai lln I KHz ^512MHz, 6ng chieu (Ong ding tryc cd dudng kfnh 22cm) Chiiu chi df lifin tyc vdi cing suat phfit cua miy P„„ = 20mW PH S 5mW Khoang cich tir thd den difn eye: 10cm, thdi gian chieu lir 10 -^ 120 phut Lam x^ nghifm mfiu, hda sinh trudc vfi sau chiiu Viba + Quan sat cfic dien biin qui trinh dieu trj vi kit qufi diiu trj trfin bfnh nhan Diiu trj vi sdng mfiy WE - 915MHz vfi Miy WE- 2,45 GHz Trong trj lifu phyc hoi chuc nfing mft lieu diiu trj ihdng ihudng M 915 MHz 700W/82H/1075-f- I5ngayho$c40W/CW/10'y2-^ 20ngiy.[23] Dieu trj vi sdng may WE- 2.45 GHz Trong Dieu trj ung thu ket hgp Dieu trj khdi u bfing vi sdng ket hgp Ihudng dieu trj moi dgt 10 lan Mdi tuan moi vj tri dieu trj tir -^ lan Moi Ifin tien hanh 45 + 60 phut, nhift dg 42 ^ 43''C Benh lanh tinh moi dgt dieu tri iir -e- 10 ISn Mdi tuin moi vj tri dieu trj tu -=-3 lan Moi lan 30 -^ 40 phin nhift dp 40-=-42''C i KET QUA VA THAO LU^N 3.1 Ket q ua Ihuc nghifm chieu len thd (m = 2kg each nguon chieu 2cm) (bang 1,2 va 3) T/^e CHl KHOA H p c & C N G NGHf CAC TRf ONG 0*1 HQC K t THUAT » S6 89 - 2012 Bang I Trgng thai Iho nghien cuu chieu cdc liiu buc xg Viba (12/07/2011) S6thc x? viba Ifin co th^ sdng, d$c bift cdng suAi phfit, i ^ 56 phit vi did! gian chiiu t&ig Ifin thi hifn dug cing rd rft Phin Idn cic thd sau chi^u WBC, PLT giim, RBC ting, Ting kha nfing di tin b^ch cllu Xil cic m9ch mfiu Idi t6 chirc xung quanh Bing cho k^t qui: Tfing GOT/AST, GPT/ALT, iflng hifn tugng thg;c bio, biin d6i mde dudng mfiu, Sg- thay d6i trfin ciia miu cCing vdt tfing ttiin hofin cgc bf sfi Ifim tfing cung d p Oxy, chk dinh dudng, chuydn hda thi;c bfio cd tfic dgng ting dinh dudng, ch6ng vtfim, giim dau vi tfing nfing sijrc dfi khfing cua co thi 3.2 Kit qui diiu tli v$t i^ (ri Iffu h6i phgc chi>c nfing Kk qufi trfin bfing 4, cho thiy tit cfi cie bfnh nhfin d^u cd t i ^ bf rd rft sau d i ^ tri trung binh dd 80 %, vfi cd 34 % khdi hfin Bdng Ket qud 18 b^nh nhdn dieu tri mdy 2450MHz trf li^u hdi phgc chitc ndng tgi b^nh vi0n TWQD'IOS (lir 12/07/2010 din 15/05/2011) HQ v i Idn VQ Thi Lfi 861 Hoing van Quynh 431 Npuyin Thj Phutmn 27i NRuyIn van Till 6O1 Bill XuSn Toin 13t NRuyenNhuQuy^tTlt Le Thi Tii 601 Le Trunp NghTa 25t HoansTraMy 191 Duong Tuan Linh It Vu Xuan Huong 68t Dang van thuonB 58t Nguyen Thj Duyen 711 T^iVan VinhSIt Hoang Kim Thanh It Dang Thanh Hang 39t Hoang van Tung 53t Tinh Ir^ns bfnh ViSm kCngdn chan T Viit Ihuong hdng ? Sung n^ m i P Sung nfi mi U^n m&t T Dau khdp gdi T Dai khdp bin chfin Dau khdp gdi T Dau khdp cd tay P Dau khdp cd ch&n P sau giy xirong Nhiem iKing gdi chan P Dau cdnh tay P h^u Zona Dau vai giy Dau khdp vai T Dau khdp gdi P DaukhdpgdiPdoTHXK Dau khdp khuyu P Lodl cd chan T Lilu diiu iri 40W/CW/i0710nBay 40W/CW/10'/8nRiy 30W/CW/I0'/9nRiy 30W/CW/IO'/3 ngfiy 30W/CW/1075 ngfiy 30W/CW/I07t4 ngfij 30W/CW/lO"/9ngdy 40W/CW/1075 ngA> 40W/CW/1075 ngfiy 30W/CW/l07l3ngfiN 30W/CW/l075ne6^ 30W/CW/l074ne^j 30W/CW/IO"/9ngfij 30W/CW/l075ngd\ 40W/CW/l(r/7ngav 40W/CW/I0 711 nuaj 3OW/CW/1O-/30 ngfiy K^l qui D&60% Dd60% D»70% Khoi Dd80% Da80% Dft70% D0f6O% D6 80% Khoi Khoi Da 60"' Da 50% Dd 80% Khoi Dd60% Dd80% Bdng Kit qud 17 h^nh nhdn dieu in mdy 9I5MHz trf lifu hdi phgc chuc ndng tgi bfnh vi^n TWQD-IOS (tir 12/07/2010 din 15/05/2011) HQ v i len HoangVanHai37l Tran Th| Bich 47l Nguyen Quoc Quan 39t Nguyen Thi Lan Anh 56t Khual Ihu liK-n22l Nguyen Thi Nang 72l Vu van Nyhi 5.1I Hoanfi Ihl) 1(11 621 Dam Ihl (Jung l l Do HOI fiOi "Iran h: Hu\On 1(11 NguyC-n Due lien 17l Ngutoi DinhChini42t' Dirirrg Ho ! an "i?l N^Lj\On hOn i u>i-n43l Dndia Vien6^t Vu Ouang Due 71)1 TinhlrfinBbanh Nhiem irung vet mo King Sung nc cang chan T Viem lav diii P Dau khtVp vai P Dau khiip hang T Dau ihan kinh hong ti> 1' Dau lirngeap Dau viing cunu eyl DJU iliil luiiii Siiu CILUI iliuong D.1U ihiin kinh hong P D.iuluni;d 1IICS \ lern khdp eung eh^u DJU ihan kinh hdng lo P Sunt! ne eSngchan T Viem khtip cung ehau P Nhiem iriint; vcl mo lung Dau than kmh hen sudn P Lilu dieu t r i 700W/82H/I07i5nga\ 40W/CW/l07l5nca> 700W/82H/Ur'2nBa> 700W/82il/l(V'15nga\ 7(Hl\V/82H/10••5nga^ 4()W/CW/|0712ncav 40\V/CW/IO-/9nHa% 40W/CW/107I1 neav 700W/82H/1073 naav 40W/CW/IO715nga\ 40W/CW/1073nga\ 40W/CW/I074ngJly 40W/CW/1079ngay 40W/CW/l0720ngay 400W/100H/10718ngay 700W/82H/10V3ngay 40W/CW/1079 Ket qua Khoi Khoi khoi Do 80% Khoi Do 40% Oa 80% Da 70% Khoi Do 80% Do 70% Do 80% Do 80% Do 80% Do 70% L^d 40% Khoi T*P CHl KHOA HOC & C6NG NGHt CAC TRUONG D.>I HOC KS THIIAT * S6 S9 - 2012 3.3 K^t qua dUu trj b&ng thSu nhift vi sdng ph6i ht/p di^u trj ung tliir Bdng Kit qud ddnh gid Idng Ihi sau 1rfprdieu Iri Iren 35 benh nhdn lai benh vien K Hd Npi Dinh D!ltl Dcrt + Bfft 11 Dot! + Dot II + Dot III gid KJioi Uxo Uxo Uxo Khoi Uxo Uxo Uxo Khoi Uxo Uxo Uxo gi&m> gidm gi&m< gi&m> gidm gidm< gidm> gidm gidm< 50% 20-40% 20% 50% 20-40% 20% 50% 20-40% 20% So 8/35 25/35 16/35 2/35 21/35 30/35 5/35 25/35 34/35 1/35 luyng (%) 23% 71% 46% 6% 60% 40% Sau d