1369 tumor specific induction of retroviral vector production using cell based carriers for cancer gene therapy

1369 Tumor Specific Induction of Retroviral Vector Production Using Cell Based Carriers for Cancer Gene Therapy Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Soci[.]

!!"7" ""        >        D"8%   D"B      "       D"8%D"B      1  D"8   D"B   D"8  %D"B                 "      D!(      E                #.          D" 8%D"B           "     3     "         1366 Control of Protein Systemic Delivery by Hypoxia Using a tet-HIF1-Alpha Chimeric T ransactivator Transactivator Delphine Bohl, Jean-Michel Heard Neuroscience, Institut Pasteur, Paris, France          ->/         ),                       "          >                                 3     -),/              C?"8           3      ),                  '                             -C '/      3 -,8H 3 / (         C '    1        3       ,,′"     3                 #8=, C D            3                          #              >        -    /   3       C '                  89  ,9           8H 3        ,,′"     3     #8=, D                         ''.",         ''.      "8"  $*'         #.              >           ''.      C ' 3         #.    *      E   #      E          "8"    G      , %        ;H 3    ,6   '       "8"     88                           6:           3                      ),                                                        1367 Long T erm Reversal of Chronic Anemia Using a Term Hypoxia Regulated Erythropoietin Gene Therapy Katie Binley,1 Zoe Askham,1 Sharifah Iqball,1 Hayley Spearman,1 Leigh Martin,1 Mahesh De Alwis,2 Adrian Thrasher,2 Susan Kingsman,1 Stuart Naylor.1 Oxford BioMedica (UK) Ltd, Oxford, Oxfordshire, United Kingdom; 2Molecular Immunology Unit, Institute of Child Health, London, United Kingdom                                        '                   ->/                               >                  > '             3      >         3   -)2C@>/         -#./     )2C@>">               >" '         S448      :9                         >" '                 "               >" '                          )2C@>">    >" '                               > 3         #.%>                                )2C@>           >                           >" '                      >          3      3           >    1368 T ranscriptional T argeting of Heterologous Transcriptional Targeting Genes to the Liver using Chimeric Promoters: In Vitro and In Vivo Comparative Study Maria G Kramer,1 Miguel A Barajas,1 Maider Zabala,1 Nerea Razquin,1 Pedro Berraondo,1 Manuel Rodrigo,1 Jesus M Prieto,1 Puri Fortes.1 Depart Internal Medicine, CIMA-University of Navarra, Pamplona, Navarra, Spain                                                 3               3G                3                          (                                                          #.  2         8"     3    '                              >3                                        "                               3                   !                  -!>/           E     $*'          )        -       /                       #.        3  89  899                         !                899      C2.                                            3   "                          1           ,       8H    #.                                        1369 T umor-Specific Induction of Retroviral V ector Tumor-Specific Vector Production Using Cell Based Carriers for Cancer Gene Therapy Marka Crittenden,1 Dragan Jevremovic,1 Michael Gough,1 Anja Ruchatz,1 John Chester,2 Victor Rivera,3 Tim Clackson,3 Francois Loic Cosset,4 Luis Alvarez-Vallina,5 Richard Vile.1 Molecular Medicine Program, Mayo Clinic, Rochester, MN, United States; 2ICRF Oncology Unit, St James Hospital, Leeds, United Kingdom; 3ARIAD Gene Therapeutics, Cambridge, MA, United States; 4INSERM U412, Lyon, France; 5Department of Immunology, Hospital Universitario Clinica Puerta de Hierro, Madrid, Spain                                                                               Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy !!"7" ""                                4          3              (2"( *-*?" 2/   3     @*'      *?"2         C    3                   >'             3      >'J                      =V  D @   3      C(.            =B&       >'    (       "      3                                                   >'J  C 88B        *            >'"         3          (2"( *                                   G                                                    3                       (2"( *                                                                                1370 Adeno-Associated Virus Mediated Interleukin10 Gene Therapy Inhibits Autoimmune Diabetes Recurrence in Syngeneic Islet T ransplanted NOD Mice Transplanted Y Clare Zhang,1 Antonello Pileggi,2 R Damaris Molano,2 Elsie Zahr,2 Raffaella Poggioli,2 Matthew Powers,1 Clive Wasserfall,1 Todd Brusko,1 Terence Flotte,3 Tamir M Ellis,1 Camillo Ricordi,2 Mark A Atkinson,1 Luca Inverardi.2 Department of Pathology, University of Florida, Gainesville, FL, United States; 2Diabetes Research Institute, University of Miami, Miami, FL, United States; 3Department of Pediatrics, University of Florida, Gainesville, FL, United States                          8                  E              !                       "89 -D"89/                    8    @   "     - ''./                  "  3                  "    ''."                 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D89 D"89      "                            88;   =%&      638954  ''."D89        8;          -&%&          6%6   ''."?!  /              -6 3 89: 4/   ''."D89 -&%&/                              D"89          "  D 3   3 #         ''."D89            "        3   #C            D"89                                        3    P N   !     1     Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 1371 Use of Adenovirus-Mediated Gene T ransfer in Transfer APOE Deficient Mice T o Elucidate the Contribution of the To Carboxyterminal Domain of APOE2 in the Development of T ype III Hyperlipoproteinemia Type Kyriakos E Kypreos,1,2 Ko Willems van Dijk,1 Louis Havekes,1 Vassilis I Zannis.2 Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands; 2Medicine, Boston University School of Medicine, Boston, MA, United States '   >          D$D          1                                      >        >"       D$D                               3        >,        G               88,   8&:                           "                >                              >,       >"   ->"%"/    ,389 5      3         >,",9,  G          >"%"                     "  >,             >"%"                 >,   >,",9,         @*'        ?"  >,           &;2DB        "   ,3895     >,     >,",9,       >"%" 3 D$D" "%"       ,3895   >6",9, 3                          >6                      ="                /         >,%,         ' 8&:→             3  ,9=",55    >, /         >" G        D$D            >"    /   >                                     S449 ...     3     "         1366 Control of Protein Systemic Delivery by Hypoxia Using a tet-HIF1-Alpha Chimeric T ransactivator Transactivator Delphine Bohl,