1087 synergistic induction of functional angiogenesis and stem cell recruitment by VEGF and angiopoietin 1 gene transfer using AAV vectors

1087 Synergistic Induction of Functional Angiogenesis and Stem Cell Recruitment by VEGF and Angiopoietin 1 Gene Transfer Using AAV Vectors Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Co[.]

  ! O 998/      3                      C? -     /  "     !(    (  "    C?     !(                              C?    -7899H C?78&9H!(7896HC?J!(78BBH!O998/'6       "     !(   C?                C?        !(      -!O998/ )        "    !(     >?   C?                                                      1085 AA V Mediated VEGF Gene T ransfer Improves the AAV Transfer Function of the Ischemic Mouse Heart Hua Su,1 Shinji Ishizaka,2 Rich Sievers,2 Janice Arakawa-Hoyt,3 William Grossman,2 Yuet-Wai Kan.1,3,4 Cardiovascular Research Institute; 2Cardiovascular Division of Internal Medicine; 3Howard Hughes Medical Institute; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States .      -.>?/                      >?8B& $*'            "     -''./                                ''.".>?                         ''.".>?          -D./                                                                   ''.".>?      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EDD(cm) AAV-VEGF 0.43±0.02 AAV-LacZ 0.44±0.02 PBS 0.52±0.03 ESD(cm) 0.23±0.01 0.27±0.01 0.39±0.06 FS(%) 46.0±2.14 38.7±1.33 26.2±7.22 d-Post 0.13±0.01 0.12±0.01 0.10±0.01 d-Ant 0.08±0.01 0.04±0.02 0.03±0.02 1086 Intracoronary Delivery of Ad5FGF-4 Results in Undetectable Levels of Systemic FGF-4 Protein Florence C Paillard,1 Ilona Canestrelli,1 Carol-Gay Yates,1 N Chin Lai,2 M Dan McKirnan,1 David A Roth,1 John Warner,1 H Kirk Hammond.2 Collateral Therapeutics, Inc., San Diego, CA, United States; Veterans Administration Medical Center, San Diego, CA, United States                 -/            3           6    -' &??"6/                                '           ' &??6            3  ??"6                   "     S352                    ??"6                ' &??"6    *            ' &??"6  8988   898,          2               = B 5   86               ??"6     G    ??"6"  >D(' ??"6              "           >D('      ≤ 56  ??"6                 ??"6       >D('       1    ??"6                             -C4.>/  @        C4.> 1  ??"6         8999 % -   3 89         >D('     / 7       ??"6                           ' &??"6           "             ??"6             ' &??"6           1087 Synergistic Induction of Functional Angiogenesis and Stem Cell Recruitment by VEGF and Angiopoietin-1 Gene T ransfer Using AA VV ectors Transfer AAV Vectors Nikola Arsic,1 Lorena Zentilin,1 Serena Zacchigna,1 Daniela Santoro,1 Giorgio Stanta,2 Alessandro Salvi,3 Gianfranco Sinagra,3 Mauro Giacca.1 Molecular Medicine, International Centre for Genetic Engineering and Biotechnology (ICGEB, Trieste, Italy; 2Istituto di Anatomia Patologica, Universita′ di Trieste, Italy; 3Unita′ di Cardiologia, Ospedale Maggiore, Trieste, Italy                                    G                           -  /               3   '                                              "                   C            "             >?8B&     8 -'8/   ''                       3                  ''.      1              3               C   -  838986   %/ ''.       >?8B&   '8   E                     -M8B     / (               ''.".>?8B& #                                                   (                $=8                          (                           ",   >?@",%A$@       "%$88;       3               !   3   >?                        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E            ,   ;    E       8&          G  -=9 =/ *.8?? 1     ??"8 @*'     1   "  !@   - 1#  I 1   89  %μ    $*'/     $*'% @*' 3      *.8?? # E            ??"8 @*' 3           -6%6/      *.8?? 1     ??"8 @*'          *.8?? 1                  *.8?? 1                       ??"8 @*'      &9H  B9 H      2 *.8?? $*'   @*'                 '   *.8?? 1    @*'         ,   6  E         E                E                       *.8?? 1     0    8&,89B  *.8?? 1             8&     E   ,&99 μ  &          999=H  998&H  E    '   ,= *.8?? 1          6   ,6           *.8??                        #                           ' *.8?? 1                  @*' 3                               *.8?? 1     3      E           #  # E            *.8??           *.8?? 1                 E               Molecular Therapy Vol 5, No 5, May 2002, Part of Parts Copyright © The American Society of Gene Therapy 1089 Processed Form of VEGF-D Is the Most Potent Angiogenesis Factor of VEGF Family Johanna E Markkanen,1 Tuomas T Rissanen,1 Marcin Gruchala,1 Mikko I Kettunen,2 Risto A Kauppinen,2 Marc G Achen,3 Steven A Stacker,3 Kari Alitalo,4 Seppo Ylä-Herttuala.1 Molecular Medicine, A I Virtanen Institute, Kuopio University, Kuopio, Finland; 2National NMR Facility, A.I Virtanen Institute, Kuopio University, Kuopio, Finland; 3Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia; 4Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland .>?                                                   .>?0            .>?"  -.>?"'"2""$ Δ*Δ.>?"   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Yuet-Wai Kan .1, 3,4 Cardiovascular Research Institute; 2Cardiovascular Division of Internal Medicine; 3Howard Hughes Medical Institute; Department of Laboratory Medicine, University of California,