SPINCONTROL ASIA Co , Ltd 24028 30, Ayothaya Tower, 17th Floor, Ratchadapisek Road, Huaykwang, Huaykwang, Bangkok 10310, THAILAND Version n°00 – 18 May 2022 CONFIDENTIAL STUDY REPORT Ref XX QF01 IV N.
DocuSign Envelope ID: A84953D1-24DD-48F9-B38A-E8B3FC76B017 CONFIDENTIAL STUDY REPORT Ref.: XX-QF01-IV-NE21 EVALUATION OF THE IN VIVO EFFICACY OF ONE COSMETIC PRODUCT USING ANTERA 3D AND SELF-ASSESSMENT IN HEALTHY ASIAN SKIN TYPE FEMALE SUBJECTS REFERENCE OF THE TEST PRODUCT: Acne-Aid Gel Scar Care (Registration No.11-1-6400029029) Study Sponsor: iNova Pharma (Thailand) Co., LTD 98 Sathorn Square Office Tower, 19th Floor, Unit 1901, North Sathorn Rd, Silom, Bangrak, Bangkok 10500 THAILAND SPINCONTROL ASIA Co., Ltd 240/28-30, Ayothaya Tower, 17th Floor, Ratchadapisek Road, Huaykwang, Huaykwang, Bangkok 10310, THAILAND Version n°00 – 18 May 2022 DocuSign Envelope ID: A84953D1-24DD-48F9-B38A-E8B3FC76B017 SITE OF EXPERIMENTATION, PARTICIPANTS 1.1 Site of experimentation SPINCONTROL ASIA Co., Ltd 240/28-30, Ayothaya Tower, 17th Floor, Ratchadapisek Road, Huaykwang, Huaykwang, BANGKOK 10310, THAILAND Phone: (+662).274.1714-18 Fax: (+662).274.1721 E-mail: spincontrolasia@spincontrolasia.com 1.2 Study Sponsor iNova Pharma (Thailand) Co., LTD 98 Sathorn Square Office Tower, 19th Floor, Unit 1901, North Sathorn Rd, Silom, Bangrak, Bangkok 10500 THAILAND 1.3 Study Monitor Ms Aruna SONGSRIKITIKUL iNova Pharma (Thailand) Co., LTD Phone: (+66).89.132.2452 Fax: (+662).119.4301 E-mail: A.Songsrikitikul@inovapharma.com 1.4 Investigator Mr Fabrice PERIN CEO– Ph.D SPINCONTROL ASIA Co., Ltd Phone: (+662).274.1714-18 Fax: (+662) 2.74.17.21 E-mail: fabrice@spincontrolasia.com Date: 23-05-2022 Signature: 1.5 Study Coordinator Ms Kunyanatt CHALOTHORN Pharmacist - M.Sc of Pharmaceutical Technology SPINCONTROL ASIA Co., Ltd Phone: (+662).274.1714-18 E-mail: kunyanatt@spincontrolasia.com Spincontrol Asia Co., Ltd 4/105 Date: 23-05-2022 Signature: XX-QF01-IV-NE21-RA DocuSign Envelope ID: A84953D1-24DD-48F9-B38A-E8B3FC76B017 Table 12b: Results of the self-assessment by the subjects about product efficacy and cosmeticity after 14 days of application Number of Subjects : 20 EFFICACY AND COSMETICITY OF THE PRODUCT A17 This product helps to brighten dark acne scar A18 This product helps to hydrate the skin A19 This product reduces post acne scars A20 In your opinion, this product reduces post acne scars by _%? (Assuming 100% at baseline) A21 This product helps to prevent acne scar A22 This product improves my skin appearance A23 This product does not cause any irritation to my skin This product has a fast absorption and does not leave any A24 stickiness on my skin A25 Based on my overall experience, how would I rate my level of satisfaction for this tested product? Acne-Aid Gel Scar Care (Registration No.11-1-6400029029) % Favorable p(Chi-2) Sign (5%) opinion 80% 3.35E-04 Yes 85% 1.02E-04 Yes 90% 2.93E-05 Yes 60%: 35% (7 out of 20), 80%: 35% (7 out of 20), 100%: 15% (3 out of 20), No change: 15% (3 out of 20) 80% 3.35E-04 Yes 90% 2.14E-05 Yes 100% 3.06E-07 Yes 95% 3.09E-06 Yes Somewhat satisfied: 35% (7 out of 20), Very satisfied: 35% (7 out of 20), Satisfied: 20% (4 out of 20), Neither satisfied nor dissatisfied: 10% (2 out of 20) Yes: Significant difference in favor of the tested product After 14 days of application After 14 days of application of the tested product Acne-Aid Gel Scar Care (Registration No.11-1-6400029029), all of the claims asked about the efficacy of the products were significantly favored opinion by the subjects from this study The percentages of favorable opinion ranged between 75% and 100% In addition, the second highest percentage of favorable opinion was obtained for the following statement: o “This product does not cause any irritation to my skin” (100%) o “This product has a fast absorption and does not leave any stickiness on my skin” (95%) Based on these results, we can conclude that the tested product Acne-Aid Gel Scar Care (Registration No.11-1-6400029029) was appreciated by the subjects of this study, as seen by the percentages of agreement ranged between 55% and 100%, during the study period on the whole face Spincontrol Asia Co., Ltd 45/105 XX-QF01-IV-NE21-RA ... EFFICACY AND COSMETICITY OF THE PRODUCT A17 This product helps to brighten dark acne scar A18 This product helps to hydrate the skin A19 This product reduces post acne scars A20 In your opinion,... of the tested product Acne-Aid Gel Scar Care (Registration No.11-1-6400029029), all of the claims asked about the efficacy of the products were significantly favored opinion by the subjects from... skin? ?? (100%) o “This product has a fast absorption and does not leave any stickiness on my skin? ?? (95%) Based on these results, we can conclude that the tested product Acne-Aid Gel Scar Care (Registration