EVALUATION, IN VIVO SUR L’HOMME, APRM03 F 020 V2 EN Report V1 0 July 16, 2021 DERMSCAN ASIA Co , Ltd 330046 47 29th Floor, Tower A Elephant Tower, Phaholyothin Road, Chomphon, Chatujak Bangkok 10900.cneAid Spot Gel AntiAcne (formula reference: INVTRT02) Study coordination: Dermscan Project Manager Preamrudee SANGTET: psadermscanasia.com Project Manager Assistant Pimrumpa VICHITNARK: pvidermscanasia.com Investigator (Dermatologist) Dr. Sujittra SOMBUNTHAM
DERMSCAN ASIA Co., Ltd 3300/46-47 29th Floor, Tower A Elephant Tower, Phaholyothin Road, Chomphon, Chatujak Bangkok 10900 THAILAND iNova Pharmaceuticals Singapore Pte Ltd 10 Eunos Road 8, #08-02 North Lobby, Singapore Post Centre (North Lobby), 408600 SINGAPORE Tel + 66 937 4377 www.dermscanasia.com Bangkok, July 16, 2021 Study Report # DA21A190 (version 1.0) Related to quote# DA21A190 EVALUATION OF THE ACUTE CUTANEOUS TOLERANCE OF A COSMETIC PRODUCT ON ADULT SUBJECTS: SINGLE PATCH TEST Acne-Aid Spot Gel Anti-Acne (formula reference: INV-TRT-02) Study coordination: Dermscan Project Manager Preamrudee SANGTET: psa@dermscanasia.com Project Manager Assistant Pimrumpa VICHITNARK: pvi@dermscanasia.com Investigator (Dermatologist) Dr Sujittra SOMBUNTHAM Dermscan Asia is certified ISO 9001 : 2015 including 13 pages APRM03-F-020_V2_EN Report_V1.0_July 16, 2021 iNova Pharmaceuticals Singapore Pte Ltd Acne-Aid Spot Gel Anti-Acne (formula reference: INV-TRT-02) DA21A190 3/13 SUMMARY OF THE STUDY REPORT # DA21A190 EVALUATION OF THE ACUTE CUTANEOUS TOLERANCE OF A COSMETIC PRODUCT ON ADULT SUBJECTS: SINGLE PATCH TEST Objective Methodology To determine the acute irritating potential of a cosmetic product after single application under patch-test Monocentric and simple blind study D0 Kinetics Collection of the subject's informed consent ● Verification of inclusion and non-inclusion criteria ● Patch-test : application ● Patch-test : removal Product Application Studied Population Results APRM03-F-020_V2_EN D2 t30min D3 t24h ● ● ● Clinical scoring Dates D2 Product reception: Study start: Study end: May 31, 2021 June 15, 2021 June 18, 2021 Reference: Form: Storage temperature: Acne-Aid Spot Gel AntiAcne (formula reference: INV-TRT-02) Translucent white gel Room temperature (Thailand Climate), (Dark place) Zone: Patch duration: Concentration Patch type: Scapular part of the back 48 hours Pure Occlusive Main inclusion criteria Average age: Number of subjects analysed: Age > 18 years old Phototype I to IV 44±1 years (18 - 60) 55 M.C.I.I value : 0.10 Conclusion: Non irritating Report_V1.0_July 16, 2021 ... OF A COSMETIC PRODUCT ON ADULT SUBJECTS: SINGLE PATCH TEST Objective Methodology To determine the acute irritating potential of a cosmetic product after single application under patch- test Monocentric...iNova Pharmaceuticals Singapore Pte Ltd Acne-Aid Spot Gel Anti-Acne (formula reference: INV-TRT-02) DA2 1A1 90 3/13 SUMMARY OF THE STUDY REPORT # DA2 1A1 90 EVALUATION OF THE ACUTE CUTANEOUS TOLERANCE. .. Monocentric and simple blind study D0 Kinetics Collection of the subject's informed consent ● Verification of inclusion and non-inclusion criteria ● Patch- test : application ● Patch- test : removal Product