From Helsinki to Istanbul What can the transplant community learn from experience in clinical research

THE REPLY I Editorial Features IN THIS ISSUE i EDITORIAL COMMENTS From Helsinki to Istanbul: What can the transplant community learn from experience in clinical research? G M Danovitch Fact or fiction of the epidemic of chronic kidney disease—let us not squabble about estimated GFR only, but also focus on albuminuria P E de Jong and R T Gansevoort (See related article by R J Glassock et al An epidemic of chronic kidney disease: fact or fiction? Nephrol Dial Transplant 2008; 23: 1117–1121.) (See related article by J Coresh et al Chronic kidney disease is common: What we next? Nephrol Dial Transplant 2008; 23: 1122–1125.) 1089 II Scientific Papers ORIGINAL ARTICLES EXPERIMENTAL NEPHROLOGY 1092 Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome H Izzedine (See related article by L Abed et al Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome Nephrol Dial Transplant 2008; 23: 1452–1455.) 1095 Periodic paralyses: when channels go wrong J.-P Lengele, ´ H Belge and O Devuyst (See related article by I Grgic et al Hyperkalaemia in a tetraplegic adolescent due to de novo sodium channel mutation Nephrol Dial Transplant 2008; 23: 1449–1451.) Proximal RTA: Are all the charts completed yet? P Gross and C Meye (See related article by Z Katzir et al Familial pure proximal renal tubular acidosis—a clinical and genetic study Nephrol Dial Transplant 2008; 23: 1211–1215.) Pharmacoeconomics in nephrology: considerations on cost-effectiveness of screening for albuminuria M J Postma, C Boersma and R T Gansevoort (See related article by A J Palmer et al A health economic analysis of screening and optimal treatment of nephropathy in patients with type diabetes and hypertension in the USA Nephrol Dial Transplant 2008; 23: 1216–1223.) 1098 1101 1103 TRANSLATIONAL NEPHROLOGY T-cells in angiotensin-II-induced vascular damage G Helmut 1107 Parvalbumin: a key protein in early distal tubule NaCl reabsorption M Zacchia and G Capasso 1109 KIDNEY DISEASES BEYOND NEPHROLOGY Kidney disease in diabetology: lessons from 2007 G Schernthaner 1112 SPECIAL FEATURE Quality of care in end-stage renal disease: the importance of comparing ‘apples with apples’ K J Jager and C Zoccali Chronic kidney disease is common: What we next? J Coresh, L A Stevens and A S Levey (See related article by P E de Jong et al Fact or fiction of the epidemic of chronic kidney disease—let us not squabble about estimated GFR only, but also focus on albuminuria Nephrol Dial Transplant 2008; 23: 1122 1092–1095.) 1116 DEBATE ON THE ‘EPIDEMIC’ OF CHRONIC KIDNEY DISEASE THE CHALLENGE An epidemic of chronic kidney disease: fact or fiction? R J Glassock and C Winearls (See related article by P E de Jong et al Fact or fiction of the epidemic of chronic kidney disease—let us not squabble about estimated GFR only, but also focus on albuminuria Nephrol Dial Transplant 2008; 23: 1117 1092–1095.) Transforming growth factor-β1 decreases epithelial sodium channel functionality in renal collecting duct cells via a Smad4-dependent pathway C.-T Chang, C.-C Hung, Y.-C Chen, T.-H Yen, M.-S Wu, 1126 C.-W Yang, A Phillips and Y.-C Tian Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury C Rosenberger, M Goldfarb, A Shina, S Bachmann, U Frei, K.-U Eckardt, T Schrader, S Rosen and S N Heyman 1135 A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy B Hohenstein, A Braun, K U Amann, R J Johnson and C P M Hugo 1144 Overexpression of PKD2 in the mouse is associated with renal tubulopathy S Burtey, M Riera, E Ribe, P Pennekamp, E Passage, R Rance, B Dworniczak and M Fontes ´ 1157 Cobalt ameliorates renal injury in an obese, hypertensive type diabetes rat model S Ohtomo, M Nangaku, Y Izuhara, S Takizawa, C van Y de Strihou and T Miyata 1166 Fluoxetine effect on kidney water reabsorption Z P Moyses, F K Nakandakari and A J Magaldi 1173 Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia L G Sanchez-Lozada, E Tapia, V Soto, C ´ ´ Avila-Casado, M Franco, L Zhao and R J Johnson 1179 In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats G Capasso, C I Di Gennaro, F D Ragione, C Manna, R Ciarcia, S Florio, A Perna, R M Pollastro, S Damiano, O Mazzoni, P Galletti and V Zappia 1186 Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation P Comoli, F Ginevri, R Maccario, M A Avanzini, M Marconi, A Groff, A Cometa, M Cioni, L Porretti, W Barberi, F Frassoni and F Locatelli 1196 CLINICAL NEPHROLOGY A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients S M Bagshaw, C George, I Dinu and R Bellomo 1203 Familial pure proximal renal tubular acidosis—a clinical and genetic study Z Katzir, D Dinour, H Reznik-Wolf, A Nissenkorn and E Holtzman (See related article by P Gross et al Proximal RTA: Are all the charts completed yet? Nephrol Dial Transplant 2008; 23: 1101–1102.) 1211 A health economic analysis of screening and optimal treatment of nephropathy in patients with type diabetes and hypertension in the USA A J Palmer, W J Valentine, R Chen, N Mehin, S Gabriel, B Bregman and R A Rodby (See related article by M J Postma et al Pharmacoeconomics in nephrology: considerations on cost-effectiveness of screening for albuminuria Nephrol Dial Transplant 2008; 23: 1103–1106.) Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1) A Kaukinen, A.-M Kuusniemi, I Lautenschlager and H Jalanko Comparison between gadolinium and iodine contrast for percutaneous intervention in atherosclerotic renal artery stenosis: clinical outcomes G C Kane, A W Stanson, D Kalnicka, D W Rosenthal, C U Lee, S C Textor and V D Garovic Improved estimation of glomerular filtration rate by serum cystatin C in preventing contrast induced nephropathy by N-acetylcysteine or zinc—preliminary results M Kimmel, M Butscheid, S Brenner, U Kuhlmann, U Klotz and D M Alscher 1216 Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement W Hu, C Liu, H Xie, H Chen, Z Liu and L Li 1307 Prolonged conservative treatment for frail elderly patients with end-stage renal disease: the Verona experience V De Biase, O Tobaldini, C Boaretti, C Abaterusso, N Pertica, C Loschiavo, G Trabucco, A Lupo and G Gambaro 1313 DIALYSIS AND TRANSPLANTATION 1224 1233 1241 Obesity is not an obstacle for successful autogenous arteriovenous fistula creation in haemodialysis W Weyde, M Krajewska, W Letachowicz, T Porazko, E Wa¸torek, M Kusztal, M Banasik, T Gołe¸biowski, H Bartosik, K Madziarska, D Janczak and M Klinger 1318 Current structure and organization for renal patient assistance in Italy S Alloatti, G F M Strippoli, G Buccianti, G Daidone and F P Schena and on behalf of the Italian Society of Nephrology 1323 Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status Y E C Taes, B Marescau, A De Vriese, P P De Deyn, E Schepers, R Vanholder and J R Delanghe 1330 1336 Blood pressure measures and risk of chronic kidney disease in men E S Schaeffner, T Kurth, T S Bowman, R P Gelber and J M Gaziano 1246 Methodological issues on the use of urinary alpha-1-microglobuline in epidemiological studies L Andersson, B Haraldsson, C Johansson and L Barregard 1252 The outcome of chronic dialysis in infants and toddlers—advantages and drawbacks of haemodialysis S Feinstein, C Rinat, R Becker-Cohen, E Ben-Shalom, S B Schwartz and Y Frishberg 1257 Analysis of NO-synthase expression and clinical risk factors in human diabetic nephropathy B Hohenstein, C P M Hugo, B Hausknecht, K P Boehmer, R H Riess and R E Schmieder 1346 Acute effects of low and high intravenous doses of furosemide on myocardial function in anuric haemodialysis patients: a tissue Doppler study S Y Hayashi, A Seeberger, B Lind, S Gunnes, A Alvestrand, M M Nascimento, B Lindholm ˚ Brodin and L.-A 1355 Chronic kidney disease prevalence in a UK residential care home population J L Carter, S E O’Riordan, G L Eaglestone, M P Delaney and E J Lamb Predictors of new-onset decline in kidney function in a general middle-European population R P Obermayr, C Temml, M Knechtelsdorfer, G Gutjahr, J Kletzmayr, S Heiss, A Ponholzer, S Madersbacher, R Oberbauer and R Klauser-Braun Correlates of ACE activity in macroalbuminuric type diabetic patients treated with chronic ACE inhibition A Nikzamir, M Nakhjavani, A Esteghamati and A Rashidi 1265 1274 Identifying patients with type diabetes at high risk of microalbuminuria: results of the DEMAND (Developing Education on Microalbuminuria for Awareness of reNal and cardiovascular risk in Diabetes) Study M C E Rossi, A Nicolucci, F Pellegrini, M Comaschi, A Ceriello, D Cucinotta, C Giorda, U Valentini, G Vespasiani and S De Cosmo 1278 Inflammatory markers and the progression of IgA glomerulonephritis K Kaartinen, J Syrjanen, I Porsti, M Hurme, ă ă A Harmoinen, A Pasternack, H Huhtala and J Mustonen 1285 Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS) R Gbadegesin, B G Hinkes, B E Hoskins, C N Vlangos, S F Heeringa, J Liu, C Loirat, F Ozaltin, S Hashmi, F Ulmer, R Cleper, R Ettenger, C Antignac, R C Wiggins, M Zenker and F Hildebrandt 1291 The prognosis and pathogenesis of severe lupus glomerulonephritis M M Schwartz, S M Korbet and E J Lewis (for the Collaborative Study Group) 1298 Resistance exercise augments the acute anabolic effects of intradialytic oral nutritional supplementation K M Majchrzak, L B Pupim, P J Flakoll and T A Ikizler 1362 Diagnostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for left ventricular dysfunction in patients with chronic kidney disease stage on haemodialysis S David, P Kumpers, V Seidler, F Biertz, H Haller ă and D Fliser 1370 Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis S Severi, E Grandi, C Pes, F Badiali, F Grandi, and A Santoro 1378 Effects of cinacalcet on gastrointestinal hormone release in patients with secondary hyperparathyroidism undergoing dialysis J J D´ıez, J L Miguel, R Codoceo, P Iglesias, M A Bajo, C Sanchez, G del Peso, F Gil, ´ J Martinez-Ara, P G Gancedo and R Selgas 1387 Geriatric comorbidities, such as falls, confer an independent mortality risk to elderly dialysis patients M Li, G Tomlinson, G Naglie, W L Cook and S V Jassal 1396 Frequency and severity of acute pancreatitis in chronic dialysis patients P G Lankisch, B Weber-Dany, P Maisonneuve and A B Lowenfels 1401 Natural killer cell alterations correlate with loss of renal function and dialysis duration in uraemic patients H Vacher-Coponat, C Brunet, L Lyonnet, E Bonnet, A Loundou, J Sampol, V Moal, B Dussol, P Brunet, Y Berland, F Dignat-George and P Paul 1406 EXCEPTIONAL CASE Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal A Santoro, E Mancini, G London, L Mercadal, H Fessy, B Perrone, L Cagnoli, E Grandi, S Severi and 1415 S Cavalcanti Glucocorticoid resistance in dialysis patients may impair the kidney allograft outcome S R De Antonio, L T S Saber, R S Chriguer and M de Castro Pre-transplant predictors of cerebrovascular events after kidney transplantation S Aull-Watschinger, H Konstantin, D Demetriou, M Schillinger, A Habicht, W H Horl ă and B Watschinger The combined effect of pre-transplant triglyceride levels and the type of calcineurin inhibitor in predicting the risk of new onset diabetes after renal transplantation E Porrini, P Delgado, A Alvarez, M Cobo, L Perez, ´ J M Gonzalez-Posada, L Hortal, R Gallego, ´ J J Garc´ıa, M Checa, A Morales, E Salido, D Hernandez and A Torres ´ Smoking behaviour of patients before and after renal transplantation M C Banas, B Banas, J Wolf, U Hoffmann, B Kruger, ă C A Boger, S R Orth and B K Kramer ă ¨ 1422 1429 1436 1442 III Clinical Reports BRIEF REPORT The basic needs of children on haemodialysis in Turkey C Ensari 1447 CASE REPORT Hyperkalaemia in a tetraplegic adolescent due to de novo sodium channel mutation I Grgic, H Si, C Depboylu, G U Hoglinger, C Busch, ă W.-T Heyken, U Kuhlmann, T Maier, R Kohler and ă J Hoyer (See related article by J.-P Lengele´ et al Periodic paralyses: when channels go wrong Nephrol Dial Transplant 2008; 23: 1098–1101.) 1449 Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome L Abed, A Merouani, E Haddad, G Benoit, L L Oligny and H Sartelet (See related article by H Izzedine Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome Nephrol Dial Transplant 2008; 23: 1095–1097.) 1452 IV Varia LETTERS AND REPLIES Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis I Shahapuni, N E L Esper, R Opisiv, Z Massy, G Choukroun, M Garabedian and A Fournier 1456 Reply K Yamada and S Fujimoto 1457 Confirming high prevalence of patients with a high risk for obstructive sleep apnoea syndrome after kidney transplantation M J D´ıaz-Atauri, P Aus´ın, J Sayas, F G Torralba and J Morales Reply M Z Molnar, I Mucsi and M Novak Cinacalcet: benefit and cost E Cohen Reply M Fukagawa and T Akizawa Cinacalcet, fetuin-A and interleukin-6 A Marino and N Giotta Reply P Messa An understanding of trace metal physiology as an aid to interpretation of clearance studies by artificial organs C J Diskin Reply M D Churchwell, I F Btaiche, D A Pasko and B A Mueller Think of oxalate when using ascorbate supplementation to optimize iron therapy in dialysis patients C Canavese, M Marangella and P Stratta Reply R M Schaefer New strategies in haemodialfiltration (HDF)—-prospective comparative analysis between online mixed HDF and mid-dilution HDF D H Krieter and B Canaud Reply C Pedrini and A Feliciani 1458 1459 1460 1460 1460 1461 1462 1462 1463 1464 1465 1466 ERRATA 1467 ANNOUNCEMENTS 1469 ... Aull-Watschinger, H Konstantin, D Demetriou, M Schillinger, A Habicht, W H Horl ă and B Watschinger The combined effect of pre -transplant triglyceride levels and the type of calcineurin inhibitor in. .. syndrome of the Finnish type (NPHS1) A Kaukinen, A.-M Kuusniemi, I Lautenschlager and H Jalanko Comparison between gadolinium and iodine contrast for percutaneous intervention in atherosclerotic... Haraldsson, C Johansson and L Barregard 1252 The outcome of chronic dialysis in infants and toddlers—advantages and drawbacks of haemodialysis S Feinstein, C Rinat, R Becker-Cohen, E Ben-Shalom, S B