CONNECTICUT STEM CELL RESEARCH ADVISORY COMMITTEE GRANT REVIEW

1 2 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 VERBATIM PROCEEDINGS CONNECTICUT STEM CELL RESEARCH ADVISORY COMMITTEE GRANT REVIEW COMMISSIONER DR ROBERT GALVIN, CHAIRMAN MARCH 31, 2009 FARMINGTON MARRIOTT CONFERENCE CENTER 15 FARM SPRINGS ROAD FARMINGTON, CONNECTICUT POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 Verbatim Proceedings of a meeting of the Connecticut Stem Cell Research Advisory Committee Grant Review held on March 31, 2009 at 8:00 a.m at the Farmington Marriott Conference Center, 15 Farm Springs Road, Farmington, Connecticut MS LYNN TOWNSHEND: First and foremost my 10 name is Lynn Townshend, I’m the Executive Aide to the 11 Commissioner, who is to my right 12 us this morning 13 wanted to just let you know a couple of things 14 trying because there are lots of papers and lots of 15 computers on the table I’m going to go at the break and 16 see if we can get an extra table added in on this side so 17 we can spread out a little bit for your own comfort 18 Thank you for joining I know it’s an early morning And I A, we’re If you have B, if you have 19 anything that you have of concern with regard to the 20 hotel, the accommodations, the food, please let me know 21 and we can our best to help you resolve that POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 C, I RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 wanted to let you know about the seating arrangements For the convenience of the Commissioner we have done assigned seats this time around and the purpose of that is for voting Commissioner, from this side on down, Mr Pescatello Dr Pescatello down to Dr Wallack is eligible to vote on every grant So everyone who is to the left of the On the other side of Chelsey we have three people who are ineligible to vote on Yale, but can vote on 10 UConn 11 ineligible to vote on UConn but may vote on Yale 12 you’re all kind of grouped together by how you can vote, 13 etcetera, etcetera 14 this over to Commissioner Galvin for a few opening 15 comments And then we have the three people who are 16 So So actually now I’m going to hand CHAIRMAN ROBERT GALVIN: Good morning and 17 thank you all for taking time from your frenetic schedules 18 to come and this very important task 19 very hard and I think effectively to arrange things as 20 best we can 21 funding and to explain to the Legislative body that We are also working very hard to protect our We have worked POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 4 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 although we have over $12,000,000 in the account it’s all been obligated and it’s been a bit of a task to make them understand that they can’t appropriate the money that’s already been contracted Before we get started I’d like to take a few minutes and let Ann Kiessling share with us some of her newest research, which I believe is quite noteworthy DR ANN KIESSLING: Thank you I sort of didn’t know we were going to talk about this this morning 10 What we have been able to for the last year or so is 11 look at gene expression in eight cell human embryos and 12 this hasn’t been done before for all kinds of reasons 13 chose that stage of embryo development because that’s the 14 penultimate toady potent cell 15 embryo has already activated it’s gene expression 16 has not undergone any differentiation yet so each cell 17 in that embryo is totally committed to nothing at all We So an eight cell human It is 18 We’re able to this because we have some 19 collaborators in Athens, Greece that have never initiated 20 in the university hospital an embryo cryo preservation 21 program So they occasionally have couples who come POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 through in vitro fertilization and there’s no Greek law that they can only return three fertilized eggs to each couple and so occasionally there was a couple who had more than three fertilized eggs particular I the person who runs that program actually trained in my lab at Harvard about 25 years ago So I know how they things there And that’s a staff in that We visited there from time to time and they had a wonderful group of people that were able to 10 once the embryos were transferred the ones that were left 11 if they developed normally one more day they were flash 12 frozen so that we could isolate the RNAs and we took 13 advantage of some new technology and what we discovered 14 actually is that these cells have a cell cycle unlike any 15 other 16 way in terms of what induce pluripotent stem cells should 17 be what should be the aim of that 18 So we hope that this is actually going to lead the CHAIRMAN GALVIN: Outstanding Thank you 19 for sharing that with us 20 business I’m going to yield the floor to Dr Latham who 21 has some a suggestion, which I think is a good one Before we transact any other POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 DR STEPHEN LATHAM: Thank you Commissioner that we delay any consideration of any of the grants that are in the lower half of the available peer review score That is to say, above 2.5, unless someone has a particular favorite grant in that range the better peer review ranked grants for us to consider with the amount of funding that we have above that level Yes, I have two suggestions The first is There’s more than enough of And the second thing I would recommend is 10 that the first thing we consider be the core grant which 11 is one of the highest peer reviewed, but also two and a 12 half million dollars 13 with that one first is that if we decide to grant the 14 core grant then we’ll have a much better idea of how much 15 money we’re working with for the remainder of the grants 16 and how high the bar ought to be set there 17 The reason I think we ought to go MS TOWNSHEND: Just one note for the 18 record 19 Ju (phonetic), is peer reviewed scored at 2.0 20 a mistake in what was distributed to you 21 there as a 3.0 Please note that Investigative Grant B-21, Chen It had been in It is a 2.0, which I think would be There was POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 relevant to the conversation at hand CHAIRMAN GALVIN: Now I presume you’ll all make that change and I presume you all understand what Steve is trying to say consideration of lower ranking grants because we have so many higher ranking grants, but that we this large grant first to give us a sense of such a large financial commitment and then it will give us some perspective about what we’re going to with the rest of the money One is that we postpone This 10 is a procedural change or adaptation 11 need a motion unless the remainder of the members would 12 like to discuss what we’re going to 13 understand what we’re going to potentially? 14 you want it as a motion? I’m not sure we Everybody Okay Do 15 VOICE: 16 DR MYRON GENEL: (Indiscernible, too far 18 CHAIRMAN GALVIN: Wait a minute 19 DR GENEL: 17 Commissioner? from mic.) Okay Just one proviso and that is 20 that we revisit the funding overall at the end of this 21 We may decide after we’ve reviewed the other grants that POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 we need to if we need more money, we may want to cut more back from we may want to cut some funding back or cut more funding back from the stem cell CHAIRMAN GALVIN: Yeah What I my understanding Mike is that that’s what we would this would at least give us a start point and then say well, we may at some point in the procedure decide we’re going to look at that in another fashion MR ROBERT MANDELKERN: But Yes Bob? Commissioner? I 10 think we shouldn’t be thrown off by the two and a half 11 million that’s been requested for the core extension 12 because we know that in past years we’ve gone through from 13 beginning to end and then come down by shaving 14 proportionately 15 no objection to the procedure if the Chair chooses it, but 16 for the new members that’s not a firm commitment to 2.5 17 So my only caution would be that I have CHAIRMAN GALVIN: Okay I think Dr Genel 18 already said that though 19 a potential starting point and then we may come back and 20 adjust this or when we look at the whole package of grants 21 I think this kind of makes this is actually we must We’re just going to use this as POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 have had a telepathic connection between Mike and myself because I kind of thought was thinking this through yesterday Yes Bob? MR MANDELKERN: One other point On the higher scores from 2.5 and up are we not obligated to at least give them the one minute of reporting out of respect? Is that not a legal obligation? CHAIRMAN GALVIN: legal obligation No We don’t have a We can read them into the record, but 10 we don’t have an obligation to consider and vote on every 11 single grant 12 record, particularly if they’re threes and a half’s and 13 fours, I don’t think any of us would seriously consider a 14 grant like that unless there was some special reason 15 without further adieu we will then consider the big grant 16 We can procedurally just read them into the MS TOWNSHEND: And This is Core Grant 17 SCDUCHC1, Ren-He Xu, which is peer review scored at 1.3 18 and is asking for $2.5 million 19 CHAIRMAN GALVIN: We have some new members 20 here, would you want to just briefly go let them know 21 how we things? POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 10 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 MS TOWNSHEND: and I can read the whole all of the pages need to note is that any decisions made here are contingent upon receipt of available funds from the Tobacco Trust Fund, which is certainly noted and needs to go into the record Well, how we things, One thing I Regarding discussion and voting please note that only Committee members who are eligible to vote on a grant may participate in discussion of the grant, 10 which goes back to the whole seating arrangement issue 11 If you are not eligible to vote on a grant due to conflict 12 of interest please not participate in the discussion of 13 that grant 14 If you have an objection and are eligible 15 to vote on a grant and wish to see an application placed 16 in a category other than that of the consensus of the 17 eligible group, the three categories being yes, no and 18 maybe, please make your objections known immediately 19 That objection automatically places the application under 20 the maybe category so the grant may be considered during 21 the second phase of this process POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 306 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 category to a no category at this point CHAIRMAN GALVIN: I was one of the reviewers, so I would move it Okay It’s been I need a second DR LANDWIRTH: CHAIRMAN GALVIN: a vote to take the O’Neill grant UC UCONN04? Second MS TOWNSHEND: CHAIRMAN GALVIN: 10 SCCUCONN04 MS TOWNSHEND: for that? CHAIRMAN GALVIN: 14 MS TOWNSHEND: 16 17 04 that is going to Do you want a roll call 13 15 Now we’re having become a no grant and of course not funded? 11 12 Okay no Yes Alright Yes moves it to So if somebody is voting yes they are moving it CHAIRMAN GALVIN: Okay And these cannot be UConn voters 18 MS TOWNSHEND: 19 DR ARINZEH: 20 CHAIRMAN GALVIN: 21 MS TOWNSHEND: Right No Arinzeh? No to not fund Okay No to not fund POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 Okay 307 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 Seemann? DR SEEMANN: MS TOWNSHEND: Kiessling? DR KIESSLING: Do not fund MS TOWNSHEND: Fishbone? DR FISHBONE: Abstain MS TOWNSHEND: Genel? CHAIRMAN GALVIN: DR GENEL: No Mike? Yes 10 DR SEEMANN: 11 MS TOWNSHEND: 12 DR GENEL: 13 CHAIRMAN GALVIN: 14 MS TOWNSHEND: Landwirth? 15 DR LANDWIRTH: No 16 MS TOWNSHEND: Latham? 17 DR LATHAM: 18 MS TOWNSHEND: Mandelkern? 19 MR MANDELKERN: Not fund 20 MS TOWNSHEND: 21 DR WALLACK: Yes Yes to fund? Oh, no Yes, move it to no No Wallack? No POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 308 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 MS TOWNSHEND: DR PESCATELLO: No MS TOWNSHEND: Nair? DR NAIR: MS TOWNSHEND: MS TOWNSHEND: Okay? We need two seeds for reserve too DR KIESSLING: No, we need two established 14 MR MANDELKERN: 15 CHAIRMAN GALVIN: 16 MS TOWNSHEND: Yeah, two established Two oh We have two established already 18 19 Now we have to go That is correct CHAIRMAN GALVIN: 12 17 Okay back and vote on each individual one 10 13 10 no not fund, one CHAIRMAN GALVIN: 11 No abstention Pescatello? CHAIRMAN GALVIN: We have two established We need 20 MS TOWNSHEND: 21 CHAIRMAN GALVIN: Two seeds two seeds POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 So Mina 309 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 Mina and Craig Nelson are the two established MR WAGNER: The last three didn’t get moved from a maybe were 17 was the malaria, 27 was something with the scores, and 31 the Richard Flavell issue CHAIRMAN GALVIN: MR WAGNER: out Those were the last three I don’t know if you want to use those three 10 Okay CHAIRMAN GALVIN: So we need to exclude one of those three from the wait list 11 MR MANDELKERN: Which of the three? 12 CHAIRMAN GALVIN: One is the malaria 13 grant, one is 14 MR WAGNER: 15 was an issue with the scores not matching 16 DR SEEMANN: 17 is the malaria 27 there I think we I thought we 17 agreed that the malaria moved to no 18 hold list, but it was no based on scientific research 19 20 21 It was not on the MR MANDELKERN: We’re establishing the MS TOWNSHEND: We’re looking at a couple hold list now POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 310 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 of I think the group is considering seed grants that could be put in reserve in the event that any of these contracts don’t go through MR MANDELKERN: DR SEEMANN: Okay I understand I guess I would say I would not recommend that the Flavell grant because you know you’ve got something high quality there CHAIRMAN GALVIN: 10 MS TOWNSHEND: 11 DR SEEMANN: 12 CHAIRMAN GALVIN: 13 MR WAGNER: 14 MS TOWNSHEND: 15 CHAIRMAN GALVIN: 16 19 20 21 Okay What number is that? Regardless of dollars Let’s identify that 31 31? YALE31, Richard Flavell, got a 1.8 17 18 I would recommend MR MANDELKERN: I move that go into reserve CHAIRMAN GALVIN: number one reserve Okay That will be Do we have a second for that? DR WALLACK: Second POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 311 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 CHAIRMAN GALVIN: Okay All in favor of moving the Flavell grant into reserve, the first reserve, indicate by saying aye? VOICES: CHAIRMAN GALVIN: 10 one Aye Opposed? We need one more one more in reserve MR MANDELKERN: I move that SCAYALE17, Mamoun, be put into reserve MS TOWNSHEND: Do we have a second? CHAIRMAN GALVIN: Do we have a second? 11 Motion fails, it doesn’t get a second 12 another one to be our second 13 14 15 16 DR WALLACK: Come up with Bob, was there any consideration for 09? MS TOWNSHEND: That’s one I had had marked as reserve way back in the day 17 DR WALLACK: 18 we put that one in reserve Right 19 MS TOWNSHEND: 20 DR SEEMANN: 21 MS TOWNSHEND: So I would move that 09, UCONN09 Second All in favor? That’s number POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 312 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 VOICES: MS TOWNSHEND: CHAIRMAN GALVIN: MS TOWNSHEND: yes’s Carried Okay Now we’re voting on the CHAIRMAN GALVIN: so we’re all set yes’s individually We voted on the reserves We just have to go back and vote the MS TOWNSHEND: Correct So yes means you 11 are in favor of funding this grant 12 in favor of funding this grant 13 than anything else 14 grant, which would be SCAUCONN02 15 vote on UConn, which would start with Arinzeh No means you are not It’s more for the record So we’re starting with the seed Only people allowed to 16 DR ARINZEH: 17 MS TOWNSHEND: 18 DR SEEMANN: 19 MS TOWNSHEND: Kiessling? 20 DR KIESSLING: Yes 21 MS TOWNSHEND: Fishbone? Yes Seemann? Yes Now These are roll call votes 10 Opposed? we’ve got to go back and vote individually on all these Aye POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 313 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 DR FISHBONE: MS TOWNSHEND: DR GENEL: MS TOWNSHEND: Landwirth? DR LANDWIRTH: Yes MS TOWNSHEND: Latham? DR LATHAM: MS TOWNSHEND: MR MANDELKERN: 10 MS TOWNSHEND: 11 DR WALLACK: 12 MS TOWNSHEND: 13 DR PESCATELLO: Yes 14 MS TOWNSHEND: Nair? 15 DR NAIR: 16 MS TOWNSHEND: 17 18 Yes Genel? Yes Yes Mandelkern? Yes Wallack? Yes Pescatello? Yes Motion carries The next one I have is 10, YALE10 CHAIRMAN GALVIN: Yeah, the only people on 19 the Yale the Yale folks can’t vote on the UConn grants, 20 UConn folks can’t vote on the Yale grants 21 who you are so if the votes are unanimous it’ll be the POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 You all know 314 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 same people each time and you won’t have to call the roll each time MS TOWNSHEND: the grant? DR NAIR: VOICE: Call the grant Why don’t you just call and ask for a no? How about if I just call MS TOWNSHEND: one I have is SCAYALE10 Okay Alright Anyone opposed to funding this? 10 This grant is funded 11 funding this? 12 opposed to funding this? 13 SCAUCHC13, anyone opposed to funding this? 14 funded 15 grant is funded 16 this? SCAYALE11, anyone opposed to This grant is funded SCAYALE12, anyone This grant is funded This grant is SCAUCHC14, anyone opposed to funding this? This SCAUCHC16, anyone opposed to funding 17 MR MANDELKERN: 18 MS TOWNSHEND: Yes I vote no Anyone else? 19 carries, this grant is funded 20 Marianne, 30? 21 this? Motion The next one I have is 30? SCAYALE No 30, anyone opposed to funding This grant is funded SCAUCHC34, anyone opposed to The next POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 315 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 funding this? This grant is funded CHAIRMAN GALVIN: DR WALLACK: CHAIRMAN GALVIN: Excuse me Hey Milt? I’m right here I think anybody who is going to stay overnight tonight the hotel room is already obligated, so I think we in good faith if somebody had planned to stay over tonight, I think you might have, then go ahead because we’ll pay for the hotel room anyway if you want to stay, stay So And for any of our out-of-town 10 visitors who would like to kick off their shoes and relax, 11 well, the room is being paid for and then we’ll figure out 12 something maybe to with the food tomorrow and maybe 13 we’ll have 14 MS TOWNSHEND: 15 CHAIRMAN GALVIN: 16 A picnic a picnic downtown in the park 17 MS TOWNSHEND: Alright We’re at 18 SCAYALE35, anyone opposed to funding this? 19 funded 20 grant is funded 21 would be SCAYALE45, anyone opposed to funding this? SCAYALE39, anyone opposed to funding this? This And this is the last of the seed which This grant is POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 This 316 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 grant is funded This application is funded UCBUCHC01, anyone opposed to funding this? This grant is funded Six? MS HORN: MS TOWNSHEND: to funding this? Six SCBYALE06, anyone opposed This grant is funded MR MANDELKERN: That’s the best score MS TOWNSHEND: SCBUCHC09, anyone opposed to funding this? This grant is funded SCBYALE13, anyone 10 opposed to funding this? 11 UCBYALE14, anyone opposed to funding this? It is funded 12 SCBUCHC16, anyone opposed to funding this? The grant is 13 funded 14 15 This grant is funded MR MANDELKERN: what was that number? Repeat that last one? 16 MS TOWNSHEND: 17 MR MANDELKERN: 16 is a no 18 MS TOWNSHEND: My apologies 19 DR LATHAM: 20 21 16 is a no? Go back and ask about 16 again MS TOWNSHEND: UCHC16? 17 is a yes POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 317 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 VOICES: MR MANDELKERN: MS TOWNSHEND: No No funding No funding SCBUCHC17, anyone opposed to funding this? The next one I have is 20? MS HORN: MS TOWNSHEND: MR MANDELKERN: MS TOWNSHEND: 10 opposed to funding this? Thank you It is funded 18 18? 18, UCONN18 UC SCBUCONN18, anyone It is funded 11 MR MANDELKERN: 12 MS TOWNSHEND: 20? 20 SCBUCHC20, anyone opposed 13 to funding this? It is funded SCBYALE21, anyone opposed 14 to funding this? It is funded SCB SCB wait a 15 minute, what you have? 16 MS HORN: 17 MR MANDELKERN: 18 MS TOWNSHEND: 19 Wesleyan 26, anyone opposed to funding this? 20 funded SCBYALE27, anyone opposed to funding this? 21 funded And the other one we’ve already voted on, have we Wesleyan Wesleyan Thank you Marianne POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 It is It is 318 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 not? It’s already been voted on by roll call CHAIRMAN GALVIN: Okay I would ask I’m going to ask Warren and my step-cell crew to a disc for you guys and a CD and send it out with the results of maybe what was funded so you all have the final results and perhaps a one sentence description of the grant I thought it might be worthwhile to put contact information on the Committee members because some of you who are relatively new or have been here for a while may And 10 want to contact some of the other Committee members 11 we’ll get up to date information so you’ll all have that 12 13 And unless there is anything else for the general good of the order 14 MS TOWNSHEND: 15 CHAIRMAN GALVIN: 16 public comment? Public comment oh, we have any Okay 17 DR LATHAM: 18 CHAIRMAN GALVIN: Do we need to vote on the -Okay We’re going to 19 some addition and subtraction, give us another five 20 minutes 21 MS TOWNSHEND: I’m sorry So POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 Steve? 319 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 DR LATHAM: we need to vote on the ones that are in reserve? CHAIRMAN GALVIN: MS TOWNSHEND: CHAIRMAN GALVIN: We did MS TOWNSHEND: DR LATHAM: It was a consensus Okay CHAIRMAN GALVIN: 11 MS TOWNSHEND: meeting CHAIRMAN GALVIN: 14 MS TOWNSHEND: Okay Yeah, just everybody stick around 16 17 That comes later Yeah, that’s another 13 15 So we don’t need roll call if they actually are going to go under contract? 10 12 We voted to put them in reserve We already did CHAIRMAN GALVIN: Stick around for about five minutes while Dan adds things up 18 MS TOWNSHEND: While Dan’s adding this up 19 I’m going to ask of the people who have reservations 20 this evening how many are going to be staying? 21 going to stay? POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 You aren’t 320 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 DR NAIR: I’m not going to stay because I have another 8:00 o’clock meeting tomorrow morning MS TOWNSHEND: CHAIRMAN GALVIN: COURT REPORTER: Okay That’s fine Do you want to stay on the record for this? MS TOWNSHEND: CHAIRMAN GALVIN: (Whereupon, the hearing adjourned at 2:58 10 No, that’s okay No p.m.) POST REPORTING SERVICE HAMDEN, CT (800) 262-4102 ...1 RE: CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 Verbatim Proceedings of a meeting of the Connecticut Stem Cell Research Advisory Committee Grant Review held on March... CT STEM CELL RESEARCH ADVISORY COMMITTEE MARCH 31, 2009 MR MANDELKERN: I would like to add that they’ve been successful at this core in developing two new stem cell lines, Connecticut One and Connecticut. .. mesenchymal stem cells compared to embryonic stem cells to form osteogenic cells The peer review is 2.35 peer review is that the there is really poor agreement on the derivation of mesenchymal stem cells