Lược sử đời Sinh học phân tử - Sinh h.cc ptu : - thich Huang giai voi G guy beat 'd mu ptu ÷÷:÷::÷÷ Quy CENTRAL DOGMA = TB ' PMN - - Who ' Ho ? Ho? - - - thuy E't tie-in thuy , ng bi et hoa - tri :::::: Darwin ' hoa hair n bait - - mo tr ki d- on vi caii tao Moi Chia SH TB : Wallace E't tb ctrudso.si TB I - - phair em tu ' su I lnh t b ' E l vaccine t chit sing ' - → - l cobain xdyraqtrinh Ivan! ' son g nho ' ' ' ch hoa I 't v choi voi ton ta: ' tinh ' dtruyeii - tu? sinh sais In vitro Mendel - In vivo - - AaBb d- ' tin h orig Morgan Aat f Aaf phair tinh phair x ti aabb t ab AB Aa Bb bb , , , Imm su? phair hi do:c la :p I : tile = - lien het giani gen so ' hionggtu Lược sử đời Sinh học phân tử Hien tuong Griffith - S 1928 : TN S - ( \ yBaP ke't quoi ' R - - : " p " + + tai nap tuong thug Tieri hath : S : Cho A ahh thug naiy 1986 1990 ' Kyu khuaii the ' ' polysaccharide vo , d-oi song oh → song yeii to DNA ki o ' , + ' bien nap bieri nhan nap s → I naiy tbt → Exogenous thank ' vitro DNA ' daii protein Thu ' ca.in ' ' qctinh RNA voi DNA hair bieri nap Tac : n honing : Phan ' d-cictu.cc d-anti date voi tb xd ink vi ' d- gtro.mg threat vciotb → " ca.in thud? Phair : " ch P orig dich , DNA 355 " P xaim nhierin tb E Coli phdngxa caij moi voto tb E Coli " s ' PCR , Kary trinh tu gen Maj giai - Polysaccharide e khuaii the → Cad moi : → Trg d- : Thug khuaii the + loinh AanhdaiiADN:xanh KE't quoi : do:c I : vd , : hi tain 1984 → " Hien tuning Aoi g ch che't DNA tu tb Ma d-o.am : r → " s t - DNA d-of : S Pneumonia : Pneumoniae IO Streptococcus 's khuai Phe coin ' - ' bien nap trinh 1410412003 : → tu Dii air ~ Mullis khuye tu? gidi 25.000 A Gorin : Eh ' → goin gen → plasmid trinh tu gen d- gi doing trinh tip bo I gene 0,1% 113 → Do 22% gene ng 3,164 ' ti ca.ir Nucleotide d-a dang gen dti.ec gen moi hoa kieii ninh PM → mRNA protein = 99,9% gi orig tat ' ca mn Khái niệm Co che truyeii ptu co bain to rig hop protein otieiihoabieiihie.ir ' Co che di ' ' - , phair : ! Amagi § : Polymer m.ae#aingaia4loa.iNudeotide sTa.octrudbao Chuck thong → Xud tad Dieu Quy , Nucleotide - "" chuk naing protein the " him ' trgtb " apt!!?n tab " + peo : moi to ' gina peptide a Ichi amin tong hop protein pm µ ngta, am +on g n polypeptide → ' = - f Lk rien Nuclear base - L phosphate Nhoin Phospho este Deoxy cytidy tic f- Deoxy deny tic voi the Phosphodiester hoo caii true - L RNA-L.U.r.a.ci/fDeoxythymidylicDeoxyGuanylic Cho ADN bi et g deoxyribose Daeng - a - voi haii h kieiin ' hit Cai pu ' hoa sink cud tb ' : moi Phi ein lien ke't doing gen ' nucleotide Dieu ' a phair tu Nucleotide Tai bain Tai lien ke't Nu Protein Dich , d- qi I d-on phair - htt't not hirth b hier vice viet Loi : qtrinh hoa r n - ' a amin I → - Pha " xd - , L - xd trinh tu? tin hoi → [ µ Cho DNA voi RNA Chung Go , y gen Q Trinh : ' d- e- DNA trg ' : hair Tui n-bo.ba moi hoa : Co ' che ' → ' trace d-oi trinh t.us 't Soa hot ng ' Cac a a Cad wing DNA → tbc = catch tag phuong tien Ici RNA di qua LE h protein khat nhan tag to ' hop tinh tran → ' moi Khái niệm Geri Loi : € Cao in d-on vi dit raye- ' X dinh chat d-c to ' Chute → thong he Akhieri → ' moi hoa tin ygen no ng :p toair bo : lieu true cac Cho L phair Cad d- vi di Ibo NST n Gen bon → gene : + aia kieii Bhi ein gen trg Itb tu RNA It 24 NST Acid Deo 30.000 oxy ti r , m n hair bi et cud sink rat ) nguioi (2n nu ' 3,164 ti gain) chuoi DNA tr en DN gen + - Tty the ' n hare t gen kit enzyme ' chic Carbohydrate + xtad enzyme Id protein tag protein inhale t Lipid + trc hien put h ' → cad ctr ud l bao guan qtro ng trgtb tb ng ft f- Ting hair ' ly Xu bdi tb phaii loin Pu OXH " d- c protean Protein d-a:c hthainh RNA + Protein vd Eats Acid Ribonucleic > hthank , PU , ' tren gen ribonucleic 77 100.000 Kai ' ' tray ein ' ca the ' co gene : i ta't tan hop ' - trang 3,164 - DNA Coto.am nho DNA ) : tink Cấu trúc Gen E Lipid → , Glycogen ATP , , SVNS Operon - Cai Laing ho.at doing in#*µ Operator Promoter thing - 's dieii hiei Coordinate on expression ! - Cad gen DNA e nair ' Khong Cai gen moi hod cho ' PM 'm t rein cat Th nai - - protein cao rest ± day , DM ' co chu'd ' ca ' gen it xdy d- naing Ig orig Editor L , logi their th nai 'm logic chung hair ' by , huiidu.org I a.im ' bo VK sau , Operon E ' d- ein f- intron ' o sun c) Choi n hair 1h naim rai rai DNA DNA promotor Chiu track nhii.in dihieii PM Cho moi gen t Cad ton to dudi doing cat wing mang moi Exon gen bi trg Ig trinh promoter Ahi ein d-o.am grape voi rat nhan avi cat Moi Cad I , ' nhan gain ta't phoi hop SVNC - ' I sari xefi Theo moi Vk truth duck PM hog c nhan Do - - mini DNA di Bieii hien : Ging - Terminator tin their 'm phai sais VK co nhiinglai.co Tag ' voi Cao PM ba:c I dai ' ' nhan d ' Virus ving mRNA ' Cad d- oar mang exon moi Intron diioc noi la: [ giorig Gap mRNA truong ' d SVNS nfuingnhhdn ] thank xainnh~tbhth.no ✓Motloqikysinhtrwnglo÷du.ngboma'ycua'tbchu ( DNA,PM,DM tonghgpprotei# Goiy bein Q ng uy nai ching ate ng hier cute ' - Khái niệm Seu hoqt ' - aia ' hoa tong Sau f I RNA holp RNA got phosphate d-c them voto ATP ADP trgtb # =dkeaEg Triphosphate ksoa't ohne naing Gain nguy phuong Ai hoa co tong gen d- a'p Chopher's nh man h d Eukaryote vain ' = log tb ' gen cac ' co yo ' Cac Aug - ( ' , dinh di chef tb king aiding pus bi naing hot cheek ' gin tb d-c dkhieii Aoi mt thay nhan t the b-th trayer Qotinh enzyme - L kick hoqt gen Mu'd s.us trinh - sp gen aia enzyme etc ksoa't Mu'd hot to tai bat Kai - L d- hoa ' toy naing chuyein Chuk the io hien ' - song dhi trg xaig ' Cad premotor d- hoa bhien gen Latvia ma I so , gen utig ' bhi en Dieu hota Ctu ' ' bhiein ' hot sink hoa cao Sinh rat ' ' Ahora = the bi loin qua khoi ' co ' ' moi the co trgtb tb phan bo ' phap ' I so phair hoi ksoa't ' hot sink hoa voi gen E + → thot diein Nao thudng lieu Promoter Promoter bi et Tui PMI → Protein trung tain : Promoter tr tam Basal Promoter = TATA Box = : TATA AAA - Cd ta't trg ' Protein ca Coding - ' gene : Gen mhoa protein ✓ n TATA - Binding protein Transcription factor ID Transcription factor IB pot DNA l RNA Promoter thud ng bin Anh Cac ' enhancer I ( - -1 -1 -1 wing bat Hc - ( Chia hei'd wing wing lien PM = DNA o ng d- aii tiong x 110000 ke't ' tac cad guia y " ' ca c to Co the thing I bin buo:c yo to Enhancer ' ' trg PM Ike't Ichi DNA Cno:n ' ' ' ④ PM Hi gen ' ma trg h chink gene Ac dteii tr ' drac voi tang moi ' → ving voi ' thay the't hier bhi ein ' Protein khoaingca-chxatuicaigenehoc.io ' , Ring PM promoter trung NST t Gain mug lieu hair gen tam doi tr g tung gen mo t nhan ...Lược sử đời Sinh học phân tử Hien tuong Griffith - S 1928 : TN S - ( yBaP ke't quoi ' R - - : " p " + + tai nap... nfuingnhhdn ] thank xainnh~tbhth.no ✓Motloqikysinhtrwnglo÷du.ngboma'ycua'tbchu ( DNA,PM,DM tonghgpprotei# Goiy bein Q ng uy nai ching ate ng hier cute ' - Khái niệm Seu hoqt ' - aia ' hoa tong Sau f... = catch tag phuong tien Ici RNA di qua LE h protein khat nhan tag to ' hop tinh tran → ' moi Khái niệm Geri Loi : € Cao in d-on vi dit raye- ' X dinh chat d-c to ' Chute → thong he Akhieri →