The ubiquitin-proteasome pathway in cell cycle control

... amino termini and one of several protein-protein interaction motifs carboxy ter- The ubiquitin-proteasome pathway in cell cycle control 157 minal to the F-box. In addition, some members of the F-box ... cofactor The ubiquitin-proteasome pathway in cell cycle control 151 Fig. 3 SCF protein-ubiqutin ligases marine invertebrates (Evans et al. 1983; Swenson et al...

Ngày tải lên: 25/10/2013, 21:20

... between the pRb protein family is found in the A and B subdomains. The pocket-domain is responsible for binding to proteins containing LXCXE motifs while the pocket-domain and the C-domain are involved ... cellular proteins. Although the binding site for LXCXE motif containing proteins is present in the B sub- domain, the crystal structure of the pRb A/BpocketboundtotheL...

Ngày tải lên: 25/10/2013, 21:20

... check- point pathways, the DNA and spindle-assembly checkpoint pathways. 8.1. The DNA Checkpoint Pathway DNA damage or a replication block can result in checkpoint-dependent cell cycle delay in G 1 , ... such as cell growth, in order to maintain normal cell size (reviewed in ref. 1). Significant advances in understanding such cell cycle controls have arisen from t...

Ngày tải lên: 08/04/2014, 12:50

... modeling cancer in the mouse been as great as in the large number of mutants engineered in genes encoding components of the cell cycle machinery and the pRB and p53 tumor suppressor pathways. The ... A-and B-type cyclins in G2/M) that control a family of Cdks (cyclin- dependent kinases) greatly enhanced our understanding of the complexity underlying control of the...

Ngày tải lên: 25/10/2013, 21:20

... role in the timing of senescence Senescence and Cell Cycle Control 263 induction by controlling p16 INK4a (and p19 ARF in MEFs), while the detail of the promoter regulation requires further investigations. ... review focuses on the tumor-suppressor pathways and cell cycle control during cellular senescence. 2 Role of the p53 Pathway in Senescence The tumor-supp...

Ngày tải lên: 25/10/2013, 21:20

... represents the limiting component of TGF-b1 signaling in PC12 cells. Smad2 phosphorylation wasanalysedinparentalPC12cellsandinstablePC12cells expressing TbRII-wt under the control of a doxycycline- inducible ... of PC12 cells was performed using LipofectAMINE TM (Life Technologies Inc.) according to the manufacturer’s protocol. 293T cells were maintained in minimum Eagle’s medium...

Ngày tải lên: 16/03/2014, 16:20

... [48] in the promoter regions of CLN1 and CLN2. Any one of the proteins present at the CLN2 promoter in early G 1 could, in principle, be responsible for recruiting Sin3 to the promoter. These include ... concerning the timing of Sin3 removal from the promoter are consistent with a function for both Cln3 and the downstream cyclins Cln1 and Cln2 in removing Sin3 from the...

Ngày tải lên: 23/03/2014, 05:22

... activities. In particular, in the combinations involving the decrease of glyoxalase II activity the effect is equival- ent to the modulation of the other parameters alone, as shown in the combination involving ... GSH in the glyoxalase pathway in L. infantum, as occurs in other enzymatic systems in trypanosom- atids. Substrate dependence of the glyoxalase enzym...

Ngày tải lên: 23/03/2014, 13:20

... component. The direct effect measures the value of the life of an additional individual and the indirect one the effect of the number of expected descendants. Interestingly the indirect effect has the 1 As ... expenditures for controlling the infection risk (assuming a price of one for each unit of control) and the cost of disease F(I(a, t)), which increases in the numbe...

Ngày tải lên: 28/03/2014, 16:20