Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor

... differentiation that confers upon pRB its tumor suppressor function. Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 237 The interaction of pRB with Id2 (inhibitor of differentiation) ... almost all human tumors, em- phasizing the importance of overcoming pRB- mediated growth control for tumor progression. Modeling Cell Cycle Control...

Ngày tải lên: 25/10/2013, 21:20

... of Mikhail V. Blagosklonny Cell Cycle Checkpoints and Cancer Cell Cycle Checkpoints and Cancer BLAGOSKLONNY MBIU 15 MOLECULAR BIOLOGY INTELLIGENCE UNIT 15 Cell Cycle Checkpoints and Cancer 2 investigators ... Overview This book Cell Cycle Checkpoints and Cancer addresses mechanisms of normal and cancer cell cycling, checkpoint control, the link of mitogeni...

Ngày tải lên: 10/04/2014, 11:13

... 2004), this review focuses on the tumor- suppressor pathways and cell cycle control during cellular senescence. 2 Role of the p53 Pathway in Senescence The tumor- suppressor p53 plays a key role ... Results Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/001/Published online: 23 November 2005 © Springer-Verlag Berlin Heidelberg 2005 Senescence and Ce...

Ngày tải lên: 25/10/2013, 21:20

... geminin’s localization [17]. Cancer cells have defects in the control mechanisms regulating cell cycle exit and therefore divide uncontrolla- bly. In addition, cancer cells often exhibit genomic instability ... sections and their expression levels in primary and normal d iploid vs. cancer cell lines. Our data show a c orrelation of Cdt1 and geminin expression levels wit...

Ngày tải lên: 07/03/2014, 16:20

... Brooks Cell Cycle Control Volume 296 Mechanisms and Protocols Edited by Tim Humphrey Gavin Brooks Cell Cycle Control Mechanisms and Protocols The Budding and Fission Yeasts 21 22. Saiz, J. E. and ... Pringle, J. R., and Reid, B. J. (1974) Genetic control of the cell division cycle in yeast. Science 183, 46–51. 12. Lew, D. J., Weinert, T., and Pringle, J. R. (1997...

Ngày tải lên: 08/04/2014, 12:50

... cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrest upon growth factor deprivation and ... family and added to the complexity of cell cycle regulation. This chapter will elaborate on the role of the retinoblastoma gene family in cell cycle regulation and tu...

Ngày tải lên: 25/10/2013, 21:20

... Probl Cell Differ (42) P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136681/Published online: 6 July 2005 © Springer-Verlag Berlin Heidelberg 2005 The ubiquitin-proteasome pathway in cell cycle control ... from studies on the early embryonic cell cycles of Table 1 Cell cycle targets of the anaphase promoting complex Substrate Organism Specificity factor Cell cycle functio...

Ngày tải lên: 25/10/2013, 21:20

... Cellular and Subcellular Transport: Epithe- lial Cells) Edited by SIDNEY FLEISCHER AND BECCA FLE1SCHER VOLUME 192. Biomembranes (Part W: Cellular and Subcellular Transport: Epi- thelial Cells) ... DAVID BARNES AND DAVID A. SIRBASKU VOLUME 148. Plant Cell Membranes Edited by LESTER PACKER AND ROLAND DOUCE VOLUME 149. Drug and Enzyme Targeting (Part B) Edited by RALPH G...

Ngày tải lên: 10/04/2014, 11:13

... some cancers may contribute to enhanced cell proliferation through destabilization of S100A2. This mechanism would impair the interaction with p53, and disrupt subsequent downstream cell cycle ... 2009) doi:10.1111/j.1742-4658.2009.06912.x The EF-hand protein S100A2 is a cell cycle regulator involved in tumori- genesis, acting through regulation of the p53 activation state. Meta...

Ngày tải lên: 30/03/2014, 02:20

... induces cell cycle arrest at G2 ⁄ M phase. HeLa cells were treated with MLL1 and scramble antisense sepa- rately for 24 h, and subjected to flow cytometry analysis. (A) Control cells treated with ... HCF1 results in cell cycle arrest at G1. Therefore, both physical and functional interactions of MLLs with cell cycle regulatory proteins indicate potential roles of MLLs...

Ngày tải lên: 23/03/2014, 06:20