Week 8 gene regulation in eukaryotes

... al.: Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor ... resulted in finding a total of 42 genes common to both (Additional file 10) In order to begin to understand the signif...

Ngày tải lên: 20/06/2014, 07:20

... Sensitivity of ModuleMiner' s performance to the quality of the input genes Sensitivity of ModuleMiner' s performance to the quality of the input genes The ratio of true positive genes (containing the ... ranking new target genes of the cardiac muscle TRGM were MYL3 ('cardiac myosin light chain 1'), MYOD1 ('myoblast determination protein 1'), TNNI1 ('troponin I'), and MYH3 ('m...

Ngày tải lên: 14/08/2014, 08:21

... [104,105] and in S cerevisiae [88] have lead to a profound understanding of how DNA binding, inducer binding and dimerization function in TetR This informa- Gene regulation by tetracyclines (Eur ... concentrations of tc for full induction [15] These conflicting requirements are met by the genetic organization of the resistance determinants (reviewed in [6]) and...

Ngày tải lên: 23/03/2014, 21:20

... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathwa...

Ngày tải lên: 25/10/2013, 21:20

... FEBS Regulation of hPDK2 and hPDK4 gene expression Investigations into the role of PPARa and PPARd in regulating PDK expression have been performed in human skeletal muscle cells [17,18] In human ... The alpha -isoform of glycogen synthase kinase- 3 from rabbit skeletal muscle is inactivated by p70, S6 kinase or MAP kinase- activated protein kinase- 1 in...

Ngày tải lên: 07/03/2014, 17:20

... 3 1 1 1 1 )4 71, +467 )4 71 )4 71, )1 16 )3 96 )3 48 )3 48 )3 18, +109, +201 )2 67 )2 19, )1 38, +206 )1 53 )5 3 )5 2 )5 2 +222 +260 +423 +465 +466 a Numbers refer to the position of the 5¢-end of the conserved ... throughout the brain tissue in R6/1 compared to R6/2 mice [29,30] The differences between the two transgenic line...

Ngày tải lên: 16/03/2014, 18:20

... The interplay between viral and cellular SR proteins certainly has a substantial effect on post- Table Functional interplay between viral proteins and cellular SR proteins as well as SR kinases ... Therefore, SR proteins, together with other RNA-binding proteins, coordinate the coupling of splicing and polyadenylation Viral and cellular SR pr...

Ngày tải lên: 23/03/2014, 06:20

... Interestingly, yeast growing in a colony undergoes cyclic changes in metabolism, from acidic to alkaline [46] Furthermore, alkali-producing colonies can entrain colonies in the acidic phase and ... involving oscillations and cycles, which are diffused in all disciplines of natural (and not only) sciences In biological studies over recent decades, it has become more and more c...

Ngày tải lên: 30/03/2014, 04:20

... housekeeping genes as normalizing standards is a time-honored practice in PCR and other amplification assays Warrington et al [36] addressed this question in an analysis of human adult and fetal tissues ... et al amplitude of the oscillation Inherent in many of the starting points for analysis of microarray data is the idea that the underlying process involves cells tha...

Ngày tải lên: 30/03/2014, 04:20

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 01:22

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 13:22

... inhibition of 23 24 25 intervertebral disc degeneration Int J Exp Pathol 2006, 87:17-28 Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc ... cells by the action of TNF-α Discussion This study investigates the effect of the pro-inflammatory cytokines IL-1β and TNF-α on catabolic gene expre...

Ngày tải lên: 09/08/2014, 14:20

... fluid and the alveolar macrophages of patients with IPF [9] An animal study also confirmed the role of IL -8 in pulmonary fibrosis by demonstrating that bleomycininduced lung fibrosis is attenuated ... evaluate the effect of the SNP on IL -8 gene or protein expression instead We measured IL -8 protein concentrations in the lung IL -8 protein was inc...

Ngày tải lên: 12/08/2014, 13:22

... indications of immune activation emerged in the set of over-expressed genes, including proinflammatory cytokines, chemokines, granzymes, proteinases, and receptors for inflammatory mediators ... effects may be shaped by reduced activity of the anti-inflammatory glucocorticoid transcription control pathway and a complementary increase in activity of the pro-inflammatory NF-κB/ Rel...

Ngày tải lên: 14/08/2014, 08:20