Targeting PI3KAKTmTOR signaling in Acute Myeloid Leukemia

báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx

... loading Results BPA induces dose dependent apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three ... activity of these compounds [17,18] In the present manuscript, we decided to investigate the effects of different doses of BPA on acute myeloid l...

Ngày tải lên : 18/06/2014, 15:20

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Báo cáo y học: "Current findings for recurring mutations in acute myeloid leukemia" pdf

... secondary AML (24%) and chronic myelomonocytic leukemia (CMML) (22%) [11] TET2 can convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) [20], which to be an intermediate in DNA demethylation ... AT-hook domains for DNA binding, a methyltransferase homology domain and a SET domain [81] MLL is necessary for the maintenance for HOX gene expression [82] The MLL SET domain ca...

Ngày tải lên : 10/08/2014, 21:23

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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx

... leukemia/lymphoma cell lines of T-, B- and myeloid cell origin to detect SET-NUP214 positive examples A T-ALL cell line LOUCY (1/43 T cell lines tested) and an AML cell line MEGAL (1/53 myeloid cell lines ... del(9)(q34.11q34.13) in cell lines LOUCY and Deletion del(9)(q34.11q34.13) in cell lines LOUCY and MEGAL Sequencing identified SET exon 7/NUP214 exon 18...

Ngày tải lên : 10/08/2014, 22:20

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báo cáo khoa học: "CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation" potx

... Cite this article as: Röhrs et al., CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation Journal of Hematology & Oncology 2010, 3:15 ... in- frame CEBPA mutation resulting in four (instead of three) histidine-proline repeats in the transactivation domain of the protein However, this mutation is consi...

Ngày tải lên : 10/08/2014, 22:21

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báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot

... represented in the AML samples Intra-individual analysis of the spot patterns showed a high correlation between the sample from peripheral blood and bone marrow (Table 2) On/off-phenomena of the identified ... Expression of the plasminogen activator inhibitor-2 (PAI2) was only found in patients E and F with the subtyp FAB M0 and M4, respectively T...

Ngày tải lên : 18/06/2014, 15:20

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Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx

... Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational ... DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ primary AML samples We showed that curcumin selective...

Ngày tải lên : 18/06/2014, 19:20

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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps

... Takahashi: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications Journal of Hematology & Oncology 2011 4:13 Submit your next manuscript ... The compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and be...

Ngày tải lên : 10/08/2014, 21:23

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báo cáo khoa học: "Journal of Hematology & Oncology BioMed Central Short report Open Access Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia" docx

... Neg Normal Normal Normal Aberrant Normal Normal Normal Normal Normal Normal Normal Normal Normal Aberrant Normal Normal Normal Aberrant Normal Normal Aberrant Normal Normal Aberrant Normal Normal ... Nil Normal Normal Normal Aberrant Normal Normal Normal Normal Normal Normal Aberrant Normal Aberrant Aberrant Normal Normal Normal Normal Normal Normal...

Ngày tải lên : 10/08/2014, 22:20

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báo cáo khoa học: "Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report" docx

... factor, anti-RNP antibody, and anti-SS -A antibody Bilateral hand X-rays showed mild swelling and destruction of the metacarpo-phalangeal (MP) and proximal-inter-phalangeal (PIP) joints He was diagnosed ... Hoshida Y, Xu JX, Fujita S, Nakamichi I, Ikeda J, Tomita Y, Nakatsuka S, Tamaru J, Iizuka A, Takeuchi T, Aozasa K: Lymphoproliferative disorders in rheumatoid arthritis:...

Ngày tải lên : 10/08/2014, 22:20

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báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc

... [20] In the current study, no NPM1 mutations were detected in cases with secondary AML following MDS, which is in line with previous studies associating absence or low rates of NPM1 mutations in ... Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia Med Oncol 2009, 26:460-462 Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U: Different...

Ngày tải lên : 10/08/2014, 22:21

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Báo cáo y học: "Hypocellular acute myeloid leukemia with bone marrow necrosis in young patients: two case report" ppsx

... Photomicrograph of bone marrow trephine biopsy (case 1) shows hypocellular marrow spaces with 70% of fat cells Photomicrograph of bone marrow trephine biopsy (case 1) shows hypocellular marrow spaces with ... in peripheral blood; less than 40% bone marrow hypocellularity; more than 30% blasts in bone marrow of all nucleated cells; and myeloid phenotypes of leuk...

Ngày tải lên : 11/08/2014, 19:21

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In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization

... In vitro and In vivo study of ABT- 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism and biologic characterization ... target of STAT3 3.3.9 In vivo efficacy of IDR E804 in combination with ABT- 869 for treatment of MV4-1...

Ngày tải lên : 11/09/2015, 09:06

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Báo cáo y học: "Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia" ppt

... checked by indirect enzyme-linked immunosorbent assay (ELISA), myeloma cells line SP2/0 (106) were fused with splenocytes (107) by the addition of 45% polyethylene glycol (PEG-4000) Hybridomas ... may detect the NPM-wt existing in the cytoplasm and cause false positives In this study, we analyzed the antigen epitope of NPM-mA protein and confirmed it may exist in the C-terminal...

Ngày tải lên : 08/08/2014, 18:21

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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt

Ngày tải lên : 09/08/2014, 09:21

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