acute myeloid leukemia in adults
báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot
Ngày tải lên :
18/06/2014, 15:20
... formation and maintenance of the histo-architecture Plasmonogen activator inhibitor-2 (PAI-2) Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator ... observed in four cases: Spot No 19 (annexin 6) was found in patient A in the sample of peripheral blood but not in bone marrow, in patient B an inverse constellation was detected concerning this ... Different protein expression in AML Patient/SampleNo SpotNo 19 60 91 102 103 104 115 121 122 130 Protein A #0205p 14-3-3 related Annexin 6, Calectrin (67 kDa) FK506 binding protein Ku antigen...
- 8
- 529
- 0
báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx
Ngày tải lên :
18/06/2014, 15:20
... able to induce apoptosis in leukemia cells via caspase activation and involvement of both intrinsic and extrinsic pathways of apoptosis Background The Endocrine Disrupting Compounds are defined ... 30 10 Figure BPA induces dose dependent apoptosis and cell cycle block in acute myeloid leukemia cells BPA induces dose dependent apoptosis and cell cycle block in acute myeloid leukemia cells ... FLIP: FLICE Inhibitor Protein; TRAIL: TNF Related Apoptosis Inducing Ligand; RA: Retinoic Acid; RB: Retinoblastoma Competing interests The authors declare that they have no competing interests...
- 8
- 603
- 0
Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx
Ngày tải lên :
18/06/2014, 19:20
... Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational Medicine 2011 9:71 ... S, Khanin M, Studzinski GP, Danilenko M: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia ... P-glycoprotein in acute myeloid leukemia cell lines Leukemia 1995, 9:799-807 Bailly JD, Skladanowski A, Bettaieb A, Mansat V, Larsen AK, Laurent G: Natural resistance of acute myeloid leukemia cell lines...
- 15
- 415
- 0
Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps
Ngày tải lên :
10/08/2014, 21:23
... tyrosine kinase domain point mutations that interfere with drug binding is a well-documented phenomenon in CML patients receiving therapy with imatinib [89] Preclinical studies using AML cell lines ... H, Roesel J, Giles F, et al: Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain Blood 2006, 107:293-300 93 Piloto ... FLT3 tyrosine kinase inhibitors Int J Hematol 2005, 82:100-107 70 Levis M, Tse KF, Smith BD, Garrett E, Small D: A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia...
- 10
- 435
- 0
Báo cáo y học: "Current findings for recurring mutations in acute myeloid leukemia" pdf
Ngày tải lên :
10/08/2014, 21:23
... that encode poorly characterized proteins involved in the regulation of chromatin remodeling The ASXL proteins contain a C-terminal plant homeodomain (PHD) finger and belong to the polycomb and ... alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication J Clin Oncol 2010, ... family of guanine nucleotidebinding proteins that regulate signal transduction upon binding to a variety of membrane receptors, including KIT and FLT3, and play important roles in proliferation,...
- 11
- 615
- 0
báo cáo khoa học: "Journal of Hematology & Oncology BioMed Central Short report Open Access Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia" docx
Ngày tải lên :
10/08/2014, 22:20
... Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 Blood ... Corbacioglu A, Bullinger L, Frohling S, Dohner H: Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other ... Putten W, Bijl MA, Sanders MA, Hugens W, Uitterlinden AG, Erpelinck CA, Delwel R, Lowenberg B, et al.: Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene...
- 5
- 236
- 0
báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx
Ngày tải lên :
10/08/2014, 22:20
... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... screening of 141 leukemia/ lymphoma cell lines of T-, B- and myeloid cell origin to detect SET-NUP214 positive examples A T-ALL cell line LOUCY (1/43 T cell lines tested) and an AML cell line MEGAL ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and...
- 5
- 199
- 0
báo cáo khoa học: "Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report" docx
Ngày tải lên :
10/08/2014, 22:20
... staining; original magnification: ×800) B and C: Hematoxylin and eosin (HE) staining and double immunohistochemistry analyses of BM biopsy (B) and skin biopsy (C) B: HE showed the diffuse infiltration ... http://www.jhoonline.org/content/2/1/27 Figure (LNs) from autopsy Hematoxylin and eosin (HE) staining and immunohistochemistry analyses of bone marrow (BM), spleen, and lymph nodes Hematoxylin and eosin (HE) ... cases reported in the literature 1974–2001 Leukemia 2002, 16:2366-2378 Rosenthal NS, Farhi DC: Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after singleagent...
- 6
- 314
- 0
báo cáo khoa học: "CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation" potx
Ngày tải lên :
10/08/2014, 22:21
... mutations of CEBPA, encoding CCAAT/enhancing binding protein-α (C/EBPα), in acute myeloid leukemia Nature Genet 2001, 27:263-270 Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CAJ, ... resulting in four (instead of three) histidine-proline repeats in the transactivation domain of the protein However, this mutation is considered insignificant for leukemogenesis as it was detected in ... protein/protein interaction CD7 exon also contains an E2F binding site according to TFSEARCH results To test whether C/EBPα acts as direct or indirect transcriptional repressor for CD7 - by protein/DNA...
- 7
- 203
- 0
báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc
Ngày tải lên :
10/08/2014, 22:21
... mutations in 1485 adult patients with acute myeloid leukemia Blood 2006, 107:4011-4020 Ahmad F, Mandava S, Das BR: Mutations of NPM1 gene in de novo acute myeloid leukemia: determination of incidence, ... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia entity ... Corbacioglu A, Bullinger L, Fröhling S, Döhner H: Mutant nucleophosmin (NPM1) predicts favorable diagnosis in younger adults with acure myeloid leukemia and normal cytogenetics: interaction with...
- 5
- 319
- 0
Báo cáo y học: "Hypocellular acute myeloid leukemia with bone marrow necrosis in young patients: two case report" ppsx
Ngày tải lên :
11/08/2014, 19:21
... according to the extent of necrosis in the bone marrow biopsy described by Maisel et al [3] Conclusion Hypoplastic acute myeloid leukemia is a distinct nosologic entity and can affect young individuals ... growing body of literature as a rare cause of BMN Abbreviations ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia; BMN: bone marrow necrosis; G-CSF: granulocyte colony stimulating ... Editor -in- Chief of this journal 10 11 Competing interests The authors declare that they have no competing interests Authors' contributions 12 tinct from overt acute leukemia and myelodysplastic syndrome...
- 4
- 280
- 0
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
Ngày tải lên :
11/09/2015, 09:06
... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole Disease...
- 121
- 368
- 0
Targeting PI3KAKTmTOR signaling in Acute Myeloid Leukemia
Ngày tải lên :
20/06/2016, 23:12
... protein kinase 1; Akt: Protein kinase PKB/Akt Akt, a serine/threonine protein kinase also known as protein kinase B (PKB), is recruited to the inner surface of plasma membrane through the interaction ... including agents that target individual protein kinases and drugs that target multiple kinases in the pathway (44, 45) TABLE 1: Therapeutic targets in the PI3K/Akt/mTOR signaling pathways Following ... pathway including rapamycin, CCI-779, RAD001 and AP23573 Rapamycin has shown activity against many types of cancer in phase I and II clinical trials (30) Moreover, combination treatment of rapamycin...
- 6
- 215
- 0
Báo cáo khoa học: "Acute monoblastic leukemia in a FeLV-positive cat" pot
Ngày tải lên :
07/08/2014, 20:23
... form of leukemia in cats infected with FeLV is of the lymphoid lineage [12], a myeloid lineage was the affected progenitor subset found in the patient described in this study This finding may ... stainings of undifferentiated blasts: (A and B) blasts were round to ovoid in shape with finely stippled nuclear chromatin and distinct nucleoli (WrightGiemsa stain); (C) a blast with a prominent ... to retrovirus-induced chromosomal translocation involving chromosome 11q 23, and rearrangement of a gene referred to as myeloid/ lymphoid or mixed lineage Acute monoblastic leukemia in a FeLV-positive...
- 3
- 289
- 0
Báo cáo y học: "Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia" ppt
Ngày tải lên :
08/08/2014, 18:21
... mutations during the course of dis- 17 18 19 20 21 22 23 24 25 26 27 ease in patients with acute myeloid leukemia Haematologica 2007; 92:1268-9 Falini B, Martelli MP, Bolli N, et al Acute myeloid leukemia ... multilineage involvement in acute myeloid leukemia: Impact on WHO classification Blood 2006; 108:4146-55 Papadaki C, Dufour A, Seibl M, et al Monitoring minimal residual disease in acute myeloid leukaemia ... raised a mAb (T26) only against NPM1 mutants by using a 19-aminoacid polypeptide immunogen (CLAVEEVLSRK) containing the unique C-terminus of the NPM-mA protein It indicated that the specific...
- 6
- 431
- 0
Báo cáo y học: "Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms" pps
Ngày tải lên :
10/08/2014, 21:23
... Das-Gupta E, Russell N: Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia Clin Cancer Res 2004, 10:2675-2680 Dufloth ... idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study J Clin Oncol 1992, 10:1103-1111 Cassileth PA, Harrington DP, Appelbaum ... 22:1132-1140 Quattrin N: Follow up of sixty-two cases of acute basophilic leukemia Biomedicine 1978, 28:72-79 Peterson LC, Parkin JL, Arthur DC, Brunning RD: Acute basophilic leukemia: a clinical, morphologic...
- 8
- 306
- 0
Báo cáo y học: "A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome" ppsx
Ngày tải lên :
10/08/2014, 21:23
... (pirarubicin plus cytarabine/homoharringtonine plus cytarabine); 3: DA/HA/IA (daunorubicin plus cytarabine/ homoharringtonine plus cytarabine/idarubicin plus cytarabine); 4: DAH/MAE (daunorubicin plus ... treatment of relapsed acute myeloid leukemia Rinsho Ketsueki 1995, 36(3):165-174 36 Saito K: Low-dose cytosine arabinoside and aclarubicin in combination with granulocyte colony-stimulating factor for ... low-dose cytosine arabinoside and aclarubicin in combination with granulocyte colony-stimulating factor to intermediate-dose cytosine arabinoside and mitoxantrone with or without etoposide in the treatment...
- 36
- 714
- 0
báo cáo khoa học: "Isolation of specific and biologically active peptides that bind cells from patients with acute myeloid leukemia (AML)" doc
Ngày tải lên :
10/08/2014, 22:20
... leukemia cells that binds these peptides, demonstrate that the in vitro effects are reproducible in vivo by conducting similar experiments in animal models and finally translating these findings ... Figure HP-A2 is internalized after binding to AML cells HP-A2 is internalized after binding to AML cells AML cells were incubated with biotinylated-peptide HP-A2 (1 μM) at various time points The bound ... frequently contain normal mononuclear cells In order to develop clinically useful strategies, we were looking for peptides that, upon binding, could induce some biological change in the leukemia cell...
- 9
- 226
- 0
báo cáo khoa học: "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics" ppsx
Ngày tải lên :
10/08/2014, 22:20
... Biondi A, Saglio G, Mecucci C, Falini B: Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations Leukemia 2006, 20(6):1103-1108 ... Corbacioglu A, Bullinger L, Fröhling S, Döhner H: Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with ... of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia Nat Genet 2001, 27(3):263-270 Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer...
- 10
- 176
- 0