Dubois lupus erythematosus and related syndromes, 8e

Ngày tải lên: 26/05/2016, 13:15

... IFN system The type I IFN system comprises the inducers of type I IFN synthesis, the type I IFN genes and proteins, the cells producing type I IFNs, and the target cells affected by the IFNs The ... NIPCs/PDCs in vitro by the inhibition of endosomal acidification/maturation [23] The proposed role of the type I IFN system in SLE suggests further ther...

Ngày tải lên: 09/08/2014, 01:21

... classification and diagnosis For example, the previous presence of anti-dsDNA antibodies (by any assay) and accordingly a positive ANA test will qualify a patient with a UV-sensitive rash for SLE classification ... anti-Sm antibody results in the fulfillment of two criteria, namely criteria 10 (anti -DNA/ anti-Sm antibody) and 11 (a positive antinuclear antibodies (ANA) test,...

Ngày tải lên: 09/08/2014, 06:22

... immunofluorescent ANA pictures, and also helped edit the manuscript MS designed and coordinated the study, performed the immunoassays and the data analysis, and also edited the manuscript All authors read and ... coexist and thus about 80% of SSc has one of these autoantibodies [30] In PM/DM, patients with antiaminoacyl tRNA synthetase antibodies have antibodies again...

Ngày tải lên: 09/08/2014, 08:22

... ESR, erythrocyte sedimentation rate; SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease activity index; SLICC, Systemic Lupus International Collaborating Clinics/American ... assay; ESR, erythrocyte sedimentation rate; SLEDAI, Systemic Lupus Erythematosus Disease activity index; SLICC, Systemic Lupus International Collaborating Clinics/Ame...

Ngày tải lên: 09/08/2014, 08:23

... changes in BAFF and APRIL serum levels after rituximab therapy in 10 patients with SLE and nine patients with RA In all patients, BAFF levels increased significantly during B-cell depletion In contrast, ... strong impact of BAFF and APRIL on B-cell development/function and the deviated levels in SLE and RA, it was of interest to study the effect...

Ngày tải lên: 09/08/2014, 08:23

... elsewhere in more detail [2,89] and their interplay is illustrated in Figure Proinflammatory high-density lipoproteins and nonrheumatic diseases Other diseases in which dysfunctional, presumably proinflammatory, ... PON1 influence levels of that enzyme and are also likely to alter HDL function; at least one also predisposes to SLE [65,66] Proinflammatory high-density lipo...

Ngày tải lên: 09/08/2014, 10:23

... Interferon and granulopoiesis signatures in systemic lupus erythematosus blood J Exp Med 2003, 197:711-723 Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY: Analysis of gene expression profiles in human systemic ... Mann-Whitney test was used to analyze these data (j) The relative expression of IFIT4 was plotted against Systemic Lupus Erythematosus Disease Activity Index-2,0...

Ngày tải lên: 09/08/2014, 10:23

... they could be consumed by sPLA2 This enzyme is increased in level and activity in some inflammatory diseases and catalyzes hydrolysis of aminophospholipids, including PS, as well as phosphatidylcholine ... leukocyte-derived MPs in patients with primary circulating microparticles Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (R...

Ngày tải lên: 09/08/2014, 14:22

... marrow and poorly expressed by early-life bone marrow stromal cells Blood 2008, 111:2755-2764 doi:10.1186/ar2976 Cite this article as: Stohl W: Systemic lupus erythematosus and its ABCs (APRIL/BLyS ... BLyS/APRIL heterotrimeric enigma Abbreviations APRIL, a proliferation-inducing ligand; BAFF, B-cell activation factor of the TNF family; BLyS, B-lymphocyte stimulator; SLE, syst...

Ngày tải lên: 12/08/2014, 12:20

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 01:22

... expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16, IFI27, IFI30, IFI35, interferon-induced transmembrane protein 1, ISG15, IRF7, ... repressive effect on the expressions of most IFI genes in PBMCs in vitro in this experiment The relative expressions of three of the representative genes (t...

Ngày tải lên: 09/08/2014, 13:22

... mitochondrial DNA (mtDNA) -encoded genes - including ATP synthase (ATP6 ), cytochrome c oxidase (COX)1, COX3, cytochrome b (CYTB), NADH dehydrogenase subunit (ND)1, and ND2 - three crystallin genes, and genes ... Palomino G, Nicolucci P, Soares C, Sakamoto-Hojo E, Donadi E: Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair g...

Ngày tải lên: 12/08/2014, 15:23

... to splenomegaly), and granulocytes (as in the immune leukopenias) Hematopoietic failure syndromes are classified by dominant morphologic features of the bone marrow (Table 102 -1) While practical ... aleukemic leukemia (AML) Some acute lymphoid leukemia Some lymphomas of bone marrow Pancytopenia with Cellular Bone Marrow Primary bone marrow diseases Secondary to systemi...

Ngày tải lên: 07/07/2014, 04:20

... acquired aplastic anemia in Europe and Israel is two cases per million persons annually In Thailand and China, rates of five to seven per million have been established In general, men and women ... peak in the teens and twenties and a second rise in the elderly Etiology The origins of aplastic anemia have been inferred from several recurring clinical associations (Table 102 -2);...

Ngày tải lên: 07/07/2014, 04:20