­syndrome chemotherapy related acute myeloid leukemia aml and myelodysplastic syndromes

... VEGF and its receptors are detected in a variety of hematological malignancies, including acute lymphoblastic leukemia, 6 acute myeloid leukemia, 7,8 myelodysplastic syndromes (MDS),9 chronic leukemias,10,11 ... SUMMARY The fate of adult leukemia still remains dismal with 5-year disease free survival (DFS) 2-37% for acute myeloid leukemia (AML) The current treatment approach for AML is chemotherapy, which ... In vitro and In vivo study of ABT-869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism and biologic...

Ngày tải lên: 11/09/2015, 09:06

... These clones were then profiled with AML and normal cells Sixty-eight (15%) clones bound to CML-BC and AML cells, and were used for further studies with PB and BM cells from normal donors Of these ... CEFQQWSGKC (8/51) and CNHVCSRLGC (7/51) Table shows the Table 1: Peptide sequences and binding profiles of phage tested on leukemia and normal cells in an ELISA assay Phage Clones Sequences AML BM CML ... phage tested on leukemia and normal cells Two phage, HP-G2 and HP-C8, differ by two amino acids and displayed different binding profiles To confirm the specificity of the clones for leukemia cells,...

Ngày tải lên: 10/08/2014, 22:20

... with myelodysplastic syndromes [1], and occasional patients with acute lymphoid leukemia [19,20] and chronic myeloid leukemia [21] They have not been found in patients with chronic lymphoid leukemia, ... FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: ... adult patients with acute myeloid leukemia (AML) Blood 2006, 107:4011-4020 30 Frohling S, Scholl C, Gilliland DG, Levine RL: Genetics of myeloid malignancies: pathogenetic and clinical implications...

Ngày tải lên: 10/08/2014, 21:23

... aclarubicin and G-CSF (CAG) has been widely used in China and Japan for treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) We searched literature on CAG between 1995 and 2010 and ... 33 Abbreviations: AML: acute myeloid leukemia; MDS: myelodysplastic syndrome; MDS/tAML: MDS or MDS transformed AML; Ref: references; NR: not reported; *: total number of AML and MDS patients; ... meta-analyses and the corresponding 95% CIs The studies that enrolled both AML and MDS were separated into two groups for this analysis, indicated by -A Abbreviations: AML: acute myeloid leukemia; MDS: myelodysplastic...

Ngày tải lên: 10/08/2014, 21:23

... subgroups of AML [10] Studies employing immunophenotyping methods in acute myeloid leukemias (AML) have shown a strong correlation of surface antigen expression comparing bone marrow and peripheral ... marrow and peripheral blood cells of selected individuals (Table 2) Spot No (14-3-3 related) was only present in patient C, spot No 121 and 122 (TCHTP and variant) was only present in patient F and ... AL, DN, and JP carried out the 2D electrophoresis and all other experimental work PS, ET, and WKH coordinated the laboratory work and helped to draft the manuscript All authors read and approved...

Ngày tải lên: 18/06/2014, 15:20

... CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells Journal of Translational Medicine 2011 9:71 Submit your next manuscript to BioMed Central and take ... stratification in AML Cytometry B Clin Cytom 2003, 53:11-19 Tallman MS, Gilliland DG, Rowe JM: Drug therapy for acute myeloid leukemia Blood 2005, 106:1154-1163 Estey E, Dohner H: Acute myeloid leukaemia ... Cooperative Group: Differences in anti-apoptotic and multidrug resistance phenotypes in elderly and young acute myeloid leukemia patients are related to the maturation of blast cells Haematologica...

Ngày tải lên: 18/06/2014, 19:20

... polymorphism in NQ01, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy -related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia Clin Cancer Res 2000, 6:4091-4095 ... hematological malignancies after breast cancer chemotherapy Leuk Lymphoma 2005, 46:1183-1188 Smith RE, Bryant J, DeCillis A, Anderson S: Acute myeloid leukemia and myelodysplastic syndrome after doxorubicin- ... variants in the XPD and XRCC3 genes that are associated with lower repair capacity, conspicuously bearing on susceptibility to breast cancer and chemotherapy- related leukemia (AML) in this patient...

Ngày tải lên: 10/08/2014, 21:23

... mutations in acute myeloid leukemia J Mol Diagn 2006, 8:254-259 Andersen MT, Andersen MK, Christiansen DH, Pedersen-Bjergaard J: NPM1 mutations in therapy -related acute myeloid leukemia with ... Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML) : association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance ... Ehninger G: Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML) Blood 2006, 107:4011-4020 Wittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor...

Ngày tải lên: 10/08/2014, 22:20

... genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia Genes Chromosomes Cancer 1992, 5:227-234 Özbek U, Kandilci A, van Baal ... del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T-ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive T-ALL patients ... HOXA9 and MEIS1 homeobox genes in human myeloid leukemias Leukemia 1999, 13:1993-1999 Drexler HG: Guide to Leukemia- Lymphoma Cell Lines Braunschweig 2005 Gorello P, Elia L, La Starza R, Brandimarte...

Ngày tải lên: 10/08/2014, 22:20

... adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976–1993 and on 5098 unselected cases reported in the literature 1974–2001 Leukemia ... DC: Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after singleagent chemotherapy Am J Clin Pathol 1996, 106:676-679 Okamoto H, Teramura M, Kamatani N: Myelodysplastic ... anti-double strand DNA antibody, rheumatoid factor, anti-RNP antibody, and anti-SS-A antibody Bilateral hand X-rays showed mild swelling and destruction of the metacarpo-phalangeal (MP) and proximal-inter-phalangeal...

Ngày tải lên: 10/08/2014, 22:20

... for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B Blood 1991, 78:2520-2526 Larson RA: Is modulation of multidrug resistance a viable strategy for acute myeloid leukemia? ... Smith S, Stiff P, et al.: Azacitadine and Low-Dose Gemtuzumab Ozogamicin for the Treatment of Poor-Risk Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Relapsed, Refractory ... Gautam B, Parikh S A, et al.: FLT3 Inhibitor Therapy for Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) : Impact On Survival According to FLT3 Status Blood 2009, 114:...

Ngày tải lên: 10/08/2014, 22:21

... of leukemia by lineage and tumourigenicity Affected cell lineage Acute Chronic Lymphocytic Acute lymphocytic leukemia Chronic lymphocytic leukemia Myelogenous (Myeloid) Acute myelogenous leukemia ... various types of cancers is acute myeloid leukemia 1.2 Acute Myeloid Leukemia The etymology of the term leukemia is derived from ancient Greek, „leukos‟ meaning white and „aima‟ meaning blood ... Hypogranular variant APML M4 Acute myelomonocytic leukemia 25-30 M5a Acute monoblastic leukemia 2-10 M5b Acute monocytic leukemia M6 Erythroleukemia 3-5 M7 Megakaryoblastic leukemia 3-12 The classification...

Ngày tải lên: 11/09/2015, 09:18

... dependent apoptosis and cell cycle block in acute myeloid leukemia cells BPA induces dose dependent apoptosis and cell cycle block in acute myeloid leukemia cells (A) Cell cycle and apoptosis in ... apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three different acute myeloid leukemia models ... prostate gland volume, altered development and tissue organization of the mammary gland, altered vaginal morphology and estrous cycles, disruption of sexual differentiation in the brain, and accelerated...

Ngày tải lên: 18/06/2014, 15:20

... adult patients with acute myeloid leukemia (AML) Blood 2006; 107: 4011-20 Falini B, Sportoletti P, Martelli MP Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives ... older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study J Clin Oncol 2010; 28: 596-604 ... 21 22 23 24 25 26 27 ease in patients with acute myeloid leukemia Haematologica 2007; 92:1268-9 Falini B, Martelli MP, Bolli N, et al Acute myeloid leukemia with mutated nucleophosmin (NPM1):...

Ngày tải lên: 08/08/2014, 18:21

... classification of myeloid neoplasms and acute leukemia: rationale and important changes Blood 2009, 114:937-951 Gilliland DG, Griffin JD: The roles of FLT3 in hematopoiesis and leukemia Blood 2002, ... M, Gotze K, et al: IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation ... with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis Blood 2002, 99:4326-4335 Lowenberg B: Diagnosis and prognosis in acute myeloid leukemia the...

Ngày tải lên: 10/08/2014, 21:23

... an indicator for transplantation in acute myeloid leukemia (AML) : an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML1 0 and 12 trials Blood 2005, 106(10):N3658-3665 ... Flt3-ITD and -ITT mutations in acute myeloid leukemia Leuk Res 2005, 29(7):849-853 Mrózek K, Heinonen K, Theil KS, Bloomfield CD: Spectral karyotyping in patients with acute myeloid leukemia and a ... significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group...

Ngày tải lên: 10/08/2014, 22:20

... Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with acute myeloid leukemia or high-risk myelodysplastic syndromes ... Chaoui D, Legrand O, Marie JP: Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia- 1 down-regulation in myeloid leukemia ... T, Baskind P, Arlin ZA: Homoharringtonine in patients with myelodysplastic syndrome (MDS) and MDS evolving to acute myeloid leukemia Leukemia 1996, 10:40-42 Pigneux A, Perreau V, Jourdan E, Vey...

Ngày tải lên: 10/08/2014, 22:20

... Romani J, Zaborski M, MacLeod RAF, Drexler HG: SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia- derived cell lines J Hematol Oncol 2009, 2:3 18 Scherr M, Battmer ... patients with acute myeloid leukemia Leukemia Res 2004, 28:43-48 Page of 10 Satoh C, Tamura H, Yamashita T, Tsuji T, Dan K, Ogata K: Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic ... regulation of CD7, both in T-cell lines and in AML cell lines: (i) we found a negative correlation between CD7 promoter methylation and gene expression, and (ii) observed that a demethylating...

Ngày tải lên: 10/08/2014, 22:21

... mutations in 1485 adult patients with acute myeloid leukemia Blood 2006, 107:4011-4020 Ahmad F, Mandava S, Das BR: Mutations of NPM1 gene in de novo acute myeloid leukemia: determination of incidence, ... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia ... Bijl MA, Sanders MA, et al: Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML) : association with other abnormalities and previously established gene expression signatures and their...

Ngày tải lên: 10/08/2014, 22:21