Paraoxonase (PON1) polymorphisms as a biomarker of susceptibility to organophosphate toxicity among a cohort of singaporean workers
Paraoxonase (PON1) polymorphisms as a biomarker of susceptibility to organophosphate toxicity among a cohort of singaporean workers
... microplates and the OXItek Arylesterase /Paraoxonase Assay Kit (ZeptoMetrix Corporation, USA) Figure Determination of PON1 status Plotting diazoxonase vs paraoxonase activities breaks the population ... beginning the assay) was used as an internal control A blank determination of basal assay mixture without serum was made to account for any spontaneous hydrolysis of diluted par...
Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps
... human diseases has seen a shift in emphasis away from linkage analysis and microsatellite markers towards SNP genotyping and different analytical strategies based on association and haplotype analysis ... 21:60–64 105 Takabayashi A, Ihara K, Sasaki Y, Suzuki Y, Nishima S, Izuhara K, Hamasaki N, Hara T: Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor...
Delta amino levulinic acid dehydratase (ALAD) polymorphism and its effect on human susceptibility to renal toxicity by inorganic lead
... ALAD polymorphism, HpyCH4 SNP in intron 6, can change the function of lead with regard to renal function The exonic polymorphisms Rsa in exon and exon (Rsa39) can change the lead s effect on ALAU, ... endogenous lead, which may lead to toxic PbB levels and signs of biological effects 2.3.3 Lead Excretion and Body Lead Burden Fecal and urinary excretions are primar...
báo cáo hóa học: " Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy" doc
... duplication, chitotriosidase testing was performed, and in all cases no activity was measurable Each of these cases was excluded from further analysis Therefore, chitotriosidase activity could be assayed ... these patients had active disease at the time samples were collected Of the 42 CALD patients studied, in one case a plasma sample was not obtained, and in another and no spinal...
Báo cáo y học: "Plasma gelsolin as a biomarker of inflammation" doc
... of waxing and waning illness Both aspects of such disease entities can increase consumption as well as restrain production of plasma proteins such as gelsolin Translational research in this area ... recombinant human gelsolin can diminish evolving injury or reduce mortality rates in animal models of hyperoxia, burns, and sepsis [9-11] A particular advantage of gelsolin...
Báo cáo y học: "Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study" potx
... 274:8455-8459 Kawakita T, Shiraki K, Yamanaka Y, Yamaguchi Y, Saitou Y, Enokimura N, Yamamoto N, Okano H, Sugimoto K, Murata K, Nakano T: Functional expression of TWEAK in human hepatocellular carcinoma: ... longitudinal study, although uTWEAK levels did increase as the flare approached, the peak was at the time of the flare rather than in advance of it As the measurements were...
Báo cáo y học: " Clustering of sebaceous gland carcinoma, papillary thyroid carcinoma and breast cancer in a woman as a new cancer susceptibility disorder: a case report" pptx
... hyperfunctioning commonly involving the pituitary, adrenal, and thyroid glands, as well as myxomas (skin, heart, and breast) and lentiginosis in select areas of the Table Incidence of Internal Malignancies ... Discussion Our patient presented with multiple malignant neoplasms including sebaceous gland carcinoma, papillary thyroid carcinoma, and breast can...
Báo cáo y học: " Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers" potx
... with an inert Page of gas (argon, 350 ml/minute for 10 minutes) and was measured using a commercially available pH meter (Model 3510, Jenway, Essex, UK) Statistical analysis Data are expressed as ... statistically significant Statistical analysis was performed using the SPSS 16 statistical package (SPSS, Chicago, IL) Graphs were created using GraphPad Prism (GraphPad Software Inc, La...
Báo cáo y học: "Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury" potx
... secondary analysis of the SOAP (Sepsis Occurrence in Acutely Ill Patients) study, Payen and colleagues [1] examined the influence of fluid balance on survival of critically ill patients with AKI ... [19] As a minimum, all critically ill patients should have an estimate of baseline ‘dry’ weight and determination of the iatrogenic daily and cumulative flu...
Báo cáo y học: "In silico evidence for the species-specific conservation of mosquito retroposons: implications as a molecular biomarker" ppt
... devastating impact of diseases such as malaria on individuals and nations within malaria endemic areas, if such nanoparticles are shown by trials to have promise for eradicating malaria, it may be ... sprayed directly into the breeding areas of mosquito larvae, namely stagnant water for the anopheles, these nanoparticles may achieve their purpose if they come quickly into cont...
Hydrogen peroxide as a potential biomarker of oxidative stress is there a reliable assay
... commonly-used biomarkers of oxidative stress/ damage and the diseases with which they are associated 13 Table 1.2 Biomarkers of oxidative stress/ damage associated with some human diseases (adapted from Valko ... biomarkers of oxidative stress/ damage isolated from tissues and biological fluids Biomarkers are defined as characteristics that can be objectively measured and eva...
Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... polymorphisms and risk of esophageal cancer, we found that variant 72Pro of alleles p53 Arg72Pro could significantly increase the risk of esophageal cancer, although the association were not significantly ... 2000 China Asian Lee JM[22] 2000 China(Taiwan) Asian Casson AG[21] 2003 Canada Caucasian Roth MJ[32] 2004 China Asian Casson AG[20] 2006 Canada Caucasian Cai L[25] 20...
Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... in disability pension risk with increase in absence days/yr A 10-day increase in absence days per annum (scale score ranging from 0-220 days/yr) yielded an increase in disability pension risk of ... sickness absence as a marker of future disability pensioning Conclusion The findings of in the present study indicate that the number of self-repor...
Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... stability of PANs was studied in the aqueous medium, and the acute toxicity of PANs was evaluated in mice Morever, EPI was loaded into PANs and its pharmacokinetics was also assessed in rats to compare ... main pharmacokinetic parameters were calculated by DAS 1.0 (Anhui, China) program Bioavailability (BA) is a measurement of the rate and extent of a therapeutically...
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