as a biomarker of brain function and plasticity
Báo cáo khoa học: Mammalian transglutaminases Identification of substrates as a key to physiological function and physiopathological relevance pot
... b-sandwich, a core (which contains a transamidation site and a Ca2+-binding site, and has a helices and b sheets in equal amounts), and two C-terminal b-barrel domains It has been suggested that glutamyl ... extrusion of TG4 from the coagulating gland [129] FXIII Coagulation FXIII is a plasma TG, and circulates in blood as a heterotetramer consisting of two catalytic A (XIIIA) and two noncatalytic B ... intracellular signalling and apoptosis, as well as in neurodegenerative and autoimmune diseases Consequently, its function may depend on its subcellular and cellular localization and on access to...
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Social Phobia as a Consequence of Brain Defects
... (accepting) accepting and negative and neutral expresssions: activation accompanied by in amygdala, evaluation of: hippocampus, Task performance: parahippocampal recognition of gyrus, medial type of emotion ... conceptually and then experimentally Pharmacological Treatments and the Neurobiology of Social phobia The demonstrated efficacy of various pharmacological compounds reducing distress and avoidance has ... (noradrenaline, adrenaline, and/ or dopamine) and are assumed to reflect a pronounced and persistent increase in sympathetic activity Studies reporting performance-related elevations in noradrenaline and adrenaline...
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báo cáo hóa học: " Chitotriosidase as a biomarker of cerebral adrenoleukodystrophy" doc
... these patients had active disease at the time samples were collected Of the 42 CALD patients studied, in one case a plasma sample was not obtained, and in another and no spinal fluid was available ... was that captured closest to year post transplant, considering data obtained at least 100 days after transplant and not greater than 18 months after transplant The change in Loes and functional ... duplication, chitotriosidase testing was performed, and in all cases no activity was measurable Each of these cases was excluded from further analysis Therefore, chitotriosidase activity could be assayed...
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Báo cáo y học: "Plasma gelsolin as a biomarker of inflammation" doc
... of waxing and waning illness Both aspects of such disease entities can increase consumption as well as restrain production of plasma proteins such as gelsolin Translational research in this area ... than years ago from Biogen, which was studying the inhalational administration of recombinant human gelsolin to patients with cystic fibrosis More recently, MJD has been an informal and unpaid ... recombinant human gelsolin can diminish evolving injury or reduce mortality rates in animal models of hyperoxia, burns, and sepsis [9-11] A particular advantage of gelsolin therapy over previously failed...
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Báo cáo y học: "Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study" potx
... longitudinal study, although uTWEAK levels did increase as the flare approached, the peak was at the time of the flare rather than in advance of it As the measurements were based on a relatively small ... renal disease that dictates uTWEAK levels, as a significant association was found between LN activity as measured by the rSLEDAI, and uTWEAK (r = 0.388, P = 0.047) Urinary TWEAK is a marker of ... patient's renal disease activity is therefore highly desirable We show here that uTWEAK can serve as a biomarker of LN, both as a one-time measurement and as a means of monitoring individual patients...
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báo cáo khoa học: "Emotional stress as a trigger of myasthenic crisis and concomitant takotsubo cardiomyopathy: a case report" pot
... was calculated as 32% on a cardiac catheterization and 40% on a transthoracic echocardiogram Shortly after cardiac catheterization, she developed bilateral ophthalmoparesis, significant bulbar ... microcirculation of the heart, and elevated catecholamine states [4,7] TC has been described in many different stressful and catastrophic circumstances such as car accidents, family deaths, and even major ... the manuscript JTW analyzed and interpreted the patient’s data and was a major contributor in writing the manuscript AF is a cardiologist who analyzed and interpreted the patient’s data regarding...
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Báo cáo y học: " Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers" potx
... using a commercially available pH meter (Model 3510, Jenway, Essex, UK) Statistical analysis Data are expressed as mean ± standard deviation (SD) or as median (interquartile ranges) for normally ... was measured right after EBC collection as previously described [5,8] Stable pH was achieved after deaeration with an inert Page of gas (argon, 350 ml/minute for 10 minutes) and was measured ... suggesting that it may represent a biomarker of disease severity in ex-smokers with COPD EBC pH represents a surrogate marker of airway acidification that has been associated with the presence of acidification...
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Báo cáo khoa học: "Continuously assessed right ventricular end-diastolic volume as a marker of cardiac preload and fluid responsiveness in mechanically ventilated cardiac surgical patients" pdf
... 65.7 years) undergoing elective coronary artery bypass grafting Patients with valvular heart disease, intracardiac shunts, regional myocardial asynchrony, peripheral vascular disease, preoperative ... increase in SVITD was under 10% Statistical analysis For statistical analysis, all volume variables were indexed to body surface area Statistical analysis was performed using the SPSS 12.0 software ... end-expiration, were analyzed and averaged All hemodynamic parameters were measured simultaneously after induction of anesthesia, when CCO had stabilized (T1) A second measurement was performed...
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Báo cáo khoa học: "Cystatin C: unsuited to use as a marker of kidney function in the intensive care unit" pot
... issue are warranted Competing interests The author(s) declare that they have no competing interests References 532 Villa P, Jiménez M, Soriano MC, Manzanares J, Casasnovas P: Serum cystatin C as a ... filtration rate in renal transplant recipients Clin Chem 1999, 49:1866-1868 Coll E, Botey A, Alvarez L, Poch E, Quintó LI, Taurina A, Vera M, Piera C, Darnell A: Serum cystatin C as a new marker ... as a marker of acute renal dysfunction in critically ill patients Crit Care 2005, 9:R139-R143 O’Riordan SE, Webb MC, Stowe HJ, Simpson DE, Kandarpa M, Coakly AJ, Newman DJ, Saunders JA, Lamb EJ:...
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Paraoxonase (PON1) polymorphisms as a biomarker of susceptibility to organophosphate toxicity among a cohort of singaporean workers
... substrate was paraoxon, “diazoxonase” if the substrate was diazoxon and “arylesterase activity” if the substrate was phenylacetate Measurement of concentration Serum PON1 concentration can be measured ... 61-bp and 94-bp fragments The DNA fragment containing the codon 55 polymorphism was amplified using forward 5´- CCT GCA ATA ATA TGA AAC AAC CTG -3´ and reverse 5- ´TGA AAG ACT TAA ACT GCC AGT C ... beginning the assay) was used as an internal control A blank determination of basal assay mixture without serum was made to account for any spontaneous hydrolysis of diluted paraoxon/diazoxon solutions...
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A contrastive analysis of encouraging as a speech act in english and vietnamese
... between semantics and pragmatics and covers some of the basic techniques and key concepts involved in studying and analyzing pragmatic meaning narrowest interpretation of pragmatics Đ Olshtain, E ... communication in a foreign language and partly in Communicative encouraging in English and Vietnamese as a speech act Language Teaching 1.3 SCOPE OF THE STUDY 1.2 AIMS AND OBJECTIVES 1.2.1 Aims of The ... STATEMENT OF THE PROBLEM teachers and learners of English as well as other potential interactants In the past, a series of studies regarding different speech acts of international communication...
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Tài liệu ANTHROPOLOGY: AS A SCIENCE AND AS A BRANCH OF UNIVERSITY EDUCATION IN THE UNITED STATES pptx
... phonology of languages Universal alphabets Logical relations of the parts of speech The vocabulary and the grammar of languages Distinctions between languages and dialects Mixed languages and jargons ... utensils, weapons, and agricultural, etc., implements Architecture and building Clothing and fashions Means of transportation by land and water Agriculture Domestication of plants and animals Weights, ... Eurafrica, Austafrica, Asia, America, Oceanica Causes and consequences of the migrations of races and nations a The Eurafrican Race.—Types of the white race Its first home Early migrations The...
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Tài liệu Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism docx
... mutase–prephenate dehydratase were deleted Monofunctional versions of the dehydratase and the dehydrogenase are provided by plasmid pKIMP-UAUC Random gene libraries are introduced into this strain ... strain and the ability of a cell harboring an individual library member to form a colony on minimal agar media lacking added phenylalanine and tyrosine reports on the chorismate mutase activity of ... Structure of Bacillus subtilis chorismate mutase The monofunctional chorismate mutase from B subtilis is a homotrimer and adopts a pseudo -a/ b barrel fold [38] A transition state analog, shown in a ball -and- stick...
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Tài liệu Báo cáo Y học: Use of site-specific recombination as a probe of nucleoprotein complex formation in chromatin Micha Schwikardi and Peter Droge ¨ potx
... for a phage l integrase mutant was set as 100% In each case, data were collected from six separate transfection assays, each employing two wells containing about  105 cells (C) Normalized b-Gal ... electroporation b-Galactosidase (b-gal) assays, Southern blotting and PCR b-Gal assays and Southern blotting were performed as described previously [10,17] The 32 P-labelled probe was generated by ... shown that these basic properties of chromatin are not significantly altered by the transcriptional status of DNA In contrast to loxP sites and sites I of res, the reactivity of episomal and genomic...
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Smoking and reproduction: The oviduct as a target of cigarette smoke ppt
... oviduct: a regulator of local contraction and gamete transport J Cardiovasc Pharmacol 2004, 44 Suppl 1:S248-51 111 Wijayagunawardane MP, Miyamoto A, Taquahashi Y, Acosta TJ, Nishimura M, Sato K: Angiotensin ... beat frequency assay Many of the compounds in Table were also screened using a chick chorioallantoic membrane (CAM) assay that measures growth of the CAM and chick embryo [188,189] In the CAM assay, ... screen (Table 1) were previously thought to be safe and are included on the FEMA GRAS list (Flavor and Extract Manufacturers' Association – Generally Regarded As Safe) and the FDA EAFUS list...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... pathway, the PKB pathway and the Janus kinase ⁄ signal transducer and activator of transcription (JAK-STAT) pathway, to promote proliferation, survival and transformation [56,57] The importance ... protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacodynamic relationship, and potential for combination in preclinical models ... Conclusions A combination of basic and applied biology in the last years has provided a good working model for how BIM is inhibited by survival signalling pathways, notably the ERK1 ⁄ pathway, and has...
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The welfare state as a determinant of women’s health: support for women’s quality of life in Canada and four comparison nations pptx
... Canada and four comparison nations, 2001 Canada Overall rank Seats in parliament (%) Female legislators, senior of cials, managers (%) Female professional and technical workers (%) Ratio female:male ... by social democratic (Sweden, Finland, Norway, Denmark, and Austria), Christian democratic (Belgium, Netherlands, Germany, France, Italy, Switzerland), or liberal Anglo-Saxon (Canada, Ireland, ... and US and to a lesser extent in Canada 9.1 Decline of the welfare state Teeple [11] sees increasing income and wealth inequalities and the weakening of social infrastructures within Canada and...
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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... http://jjj.biochem.sun ac.za/database/silva/index.html free of charge Results and Discussion The potential of the glyoxalase system as a possible therapeutic target relies on its role as the main catabolic pathway ... Sousa Silva et al The glyoxalase pathway in Leishmania infantum Table Glyoxalase I kinetic parameters in Leishmania infantum and other cells Initial rate analysis Glx I Substrate Km (mM) Leishmania ... methylglyoxal input (A) , initial trypanothione concentration and glyoxalase I activity (B), glyoxalase II activity and glyoxalase I activity (C), methylglyoxal input and glyoxalase I activity (D)...
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A Study on the Effects of Argentine Tango as a Form of Partnered Dance for those with Parkinson Disease and the Healthy Elderly pptx
... Madeleine Hackney and a grant from the American Parkinson Disease Association to Gammon Earhart References Argue, J (2000) Parkinson’s disease and the art of moving Oakland, CA: New Harbinger Beauchet, ... found that the waltz was just as good as traditional aerobic exercise and that people were happier, which was demonstrated by increases in a measure of quality of life, and greater likeliness ... the wand backwards (arms still behind chair) e Finger roll: As fast as you can, then as slow as you can; Rolling out to the sides of the wand, and back to center Come up with your own plan! From...
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Báo cáo Y học: Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin doc
... Materials and methods TRH-degrading Lectin Brain enzyme Serum enzyme Liver enzyme SNA (Sambucus nigra A. ) GNA (Galanthus nivalis A. ) MAA (Maackia amurensis A. ) DSA (Datura stramonium A. ) ConA (Concanavalin ... phosphatase or to horseradish peroxidase as well as endoglycosidase F/N-glycosidase F enzyme preparation and endoproteinase Lys-C were purchased from Roche Diagnostics GmbH (Mannheim, Germany) Goat ... conditions a molecular mass of 125 000 Da was estimated for the liver enzyme and the serum enzyme and a molecular mass of 116 000 Da for the brain enzyme, indicating that all these enzymes exist as homodimers,...
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