A potential target for tuberculosis drug discovery

A potential target for tuberculosis drug discovery

... of ATP hydrolysis, usually by ATPases of the AAA or AAA+ superfamily (ATPases associated with various cellular activities) (Neuwald et al., 1999) These ATPase chaperones or chaperonins unfold and ... trans-translation, in which an alanyl-tmRNA enters the empty A site of the ribosome causing the release of the truncated mRNA lacking a STOP codon The SsrA RNA also adds 11 amino acid tag (AA...

Ngày tải lên : 26/11/2015, 22:38

114
215
0

Báo cáo y học: "Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention of knee osteoarthritis: a longitudinal study" pdf

... Davies-Tuck et al., Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement - a potential target for prevention ... Cartilage 2007, 15:143 7-1 442 Baranyay FJ, Wang Y, Wluka AE, English DR, Giles GG, Sullivan RO, FM C: Association of bone marrow lesions...

Ngày tải lên : 12/08/2014, 11:22

8
372
0

Tài liệu Commodity-Linked Bonds: A Potential Means for Less-Developed Countries to Raise Foreign Capital doc

... in Canada on recycled paper Bank of Canada Working Paper 2004-20 June 2004 Commodity-Linked Bonds: A Potential Means for Less-Developed Countries to Raise Foreign Capital by Joseph Atta-Mensah ... Monetary and Financial Analysis Department Bank of Canada Ottawa, Ontario, Canada K 1A 0G9 jattamensah@bankofcanada.ca The views expressed in this paper are those of the aut...

Ngày tải lên : 16/02/2014, 02:20

43
870
0

Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt

... anti-placental alkaline phosphatase (PLAP) agarose (C) SDS ⁄ PAGE and silver stain of proteins isolated from AP sepharose (lane 1) and FN3d–AP sepharose (lane 2) A protein band of approximately 95 kDa is ... nucleolin, mean that calculations of binding afﬁnity are unrealistic at this stage Nucleolin localization in muscle is analogous to PTPr ligand localization To determine wh...

Ngày tải lên : 19/02/2014, 05:20

14
669
0

Báo cáo khoa học: The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba docx

... alkaline phosphase (Merck, Darmstadt, Germany; 100 U) at 37°C, as analyzed by HPLC Inﬂuence of ginkgotoxin on human pyridoxal kinase This material is available as part of the online article from ... methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo food Planta Med 62, 548–551 Scott PM, Lau BP, Lawrence GA & Lewis DA (2000) Analysis of Ginkgo...

Ngày tải lên : 07/03/2014, 10:20

10
530
0

Báo cáo khoa học: Distribution of the extrinsic proteins as a potential marker for the evolution of photosynthetic oxygen-evolving photosystem II ppt

... Chloroplast DNA Bacillariophyceae (diatoms) Thalassiosira pseudonana Nuclear DNA Chloroplast DNA Odontella sinensis Chloroplast DNA Prasinophyceae Mesostigma viride Chloroplast DNA Euglenophyceae ... glaucophyte, C paradoxa that has the most primitive plastids [23], contained the PsbV and PsbU proteins as the extrinsic proteins (Figs and 2) A primitive red alga, C caldarium th...

Ngày tải lên : 23/03/2014, 15:21

11
501
0

Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc

... limitation of the process is the identification of those antigens that are the most relevant as targets, as the human auto-antigen-specific T cell repertoire is diverse and the optimal antigen target ... Cite this article as: d’Hennezel et al.: IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in org...

Ngày tải lên : 18/06/2014, 16:20

12
573
0

Báo cáo y học: "Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease" pdf

... alterations of C 3a and C 5a levels bypassing the traditional complement activation cascade There are few reports on complement activation in anorexia nervosa available in the peer-reviewed literature, dating ... There are several potential explanations for this negative finding First, a recent study described direct cleavage of C5 via thrombin, thereby bypassing the...

Ngày tải lên : 09/08/2014, 01:21

6
441
0

Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

... antibody (mAb) as a drug targeting system To investigate the possibility for therapeutic intervention in arthritis, antiCD134 liposomes were loaded with a cytostatic drug and administered early in ... diseaseassociated epitope Mt HSP60176–190 Specific targeting to CD134+ T cells in draining lymph nodes with anti-CD134 liposomes For delivery of modulating compounds...

Ngày tải lên : 09/08/2014, 06:22

12
823
0

Báo cáo y học: " Histone deacetylases — a new target for suppression of cartilage degradation" pdf

... Furumatsu T, Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y, et al.: Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK 4a and p21(WAF1/Cip1) ... chemistry of the Sir2 family of NAD+-dependent histone/ protein deacetylases Biochem Soc Trans 2004, 32:904-909 Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E,...

Ngày tải lên : 09/08/2014, 06:23

2
397
0

Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot

... the RNAi machinery is that RNAi was initially recognized as an antiviral mechanism in plants and certain invertebrates [14] The evolutionary conservation of RNAi suggests a similar role for RNAi ... the RNAi machinery [16] may promote the development of autoimmunity Conclusion The identification of components of the RNAi machinery as targets of the anti-Su autoantibody syste...

Ngày tải lên : 09/08/2014, 08:22

3
311
0

Báo cáo y học: "tatin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis" pptx

... demonstrated that the regulation of CD59 by statins in hypoxia was inhibited by mevalonate and geranylgeraniol, confirming a role for inhibition of HMG-CoA reductase and geranylgeranylation, respectively ... anti-inflammatory action of statins in RA The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal att...

Ngày tải lên : 09/08/2014, 08:22

12
510
0

Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience" pdf

... therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ-zymographic and gene therapy study Arthritis Res Ther 2007, 9:R83 Le Maitre CL, Hoyland JA, Freemont ... significant improvement in clinical indicators of pain and disease activity A first randomized controlled trial in patients with knee OA demonstrated a good safety profile...

Ngày tải lên : 09/08/2014, 10:21

2
412
0

Báo cáo y học: "Three-dimensional and thermal surface imaging produces reliable measures of joint shape and temperature: a potential tool for quantifying arthritis" pdf

... reliability of thermal imaging of the wrist and MCP, normal adult wrists and hands from controls were imaged on separate days Three thermal scans were obtained at each session and the HDI was calculated ... the effect of significant deformity on this approach in a larger population of RA and JIA patients Ultimately, this approach may provide a tool to improve the a...

Ngày tải lên : 09/08/2014, 10:22

9
344
0