TLR3 induces hepatocellular carcinoma cell death and increases natural killer cell activity

... TRAIL on the liver carcinoma cells QGY-7703 To investigate the apoptotic function of TRAIL containing the extracellular domain (amino acids 114–281) of the human liver cancer cell line, QGY-7703 ... in the hepatocellular carcinoma cells, QGY-7703, we treated these cells with eight different agents, at increasing concentrations, with and without TRAIL, then analysed...

Ngày tải lên: 23/03/2014, 17:22

... complications, 114 postoperative mortality, 114 M.D Anderson Cancer Center, criteria for resection, 110t patient selection/preparation, 110 preoperative therapy chemotherapy, 118–120 PVE, perioperative outcomes/survival ... chemotherapy, 161–162 bevacizumab, administration of, 162 hepatic hypertrophy, impact on, 162 hepatic injuries, 162 408 PVE, indications and contraindications (cont.)...

Ngày tải lên: 07/07/2014, 09:20

... Hepatocellular Carcinoma Kelly M McMasters Jean-Nicolas Vauthey Editors Hepatocellular Carcinoma Targeted Therapy and Multidisciplinary Care 13 Editors Kelly ... (www.springer.com) Foreword It is a great pleasure and an honor to write the preface for this outstanding book dedicated to the therapy of hepatocellular carcinoma (HCC) This tumor, which is ... liver is a massive...

Ngày tải lên: 07/07/2014, 09:20

... Epidemiology and Pathogenesis of Hepatocellular Carcinoma Manal M Hassan and Ahmed O Kaseb Biology of Hepatocellular Carcinoma Maria Luisa Balmer and Jean-François Dufour 21 Hepatocellular ... Martin and Stewart Carter 299 20 Yttrium-90 Radioembolotherapy for Hepatocellular Cancer Ravi Murthy, Pritesh Mutha, and Sanjay Gupta 319 21 Cytotoxic Chemotherapy and Endocrine .....

Ngày tải lên: 07/07/2014, 09:20

... positive association between hypothyroidism and HCC among women [98] Whether and why hypothyroidism causes HCC is not clear However, the association between hypothyroidism and NASH can be explained ... Arachidonic acid Prostaglandin COX-2 Fig 1.2 Steps in hepatocarcinogenesis, modified from Xu et al [90] and Bensinger and Tontonoz [91] On the other hand, the association between obesi...

Ngày tải lên: 07/07/2014, 09:20

... chronic liver disease and hepatocellular carcinoma Gastroenterology 126:460–468 75 Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL et al (2008) Metabolic factors and risk of hepatocellular carcinoma ... (1998) Prognosis of hepatocellular carcinoma with diabetes mellitus after hepatic resection Hepatology 27:1567–1571 79 Dellon ES, Shaheen NJ (2005) Diabetes and hepatocellular...

Ngày tải lên: 07/07/2014, 09:20

... (2003) Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease Am J Pathol 163:1301–1311 17 Sell S (2001) Heterogeneity and plasticity of ... regeneration, fibrosis and cancer: the good, the bad and the ugly J Pathol 217:282–298 19 Mishra L, Banker T, Murray J, Byers S, Thenappan A, He AR, Shetty K, et al (2009) Liver stem...

Ngày tải lên: 07/07/2014, 09:20

... of hepatocellular carcinoma composed of wide anastomosing cords wrapped by endothelial cells Hepatocellular Cancer: Pathologic Considerations 39 Fig 3.3 Pseudoglandular (acinar) pattern of hepatocellular ... inclusions, and fibrinogen containing pale bodies, presenting as pale ground-glass cytoplasmic inclusions [24, 36, 41] Combined Hepatocellular Carcinoma and Cholangiocarcinoma...

Ngày tải lên: 07/07/2014, 09:20

... in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas Hum Pathol 37:1435–1441 Kandil DH, Cooper K (2009) Glypican-3: a novel diagnostic marker for hepatocellular ... stage IV-A hepatocellular carcinoma without lymph node metastasis: proposal as a standard therapy Ann Surg 227: 433–439 21 Kojiro M, Sugihara S, Kakizoe S, Nakashima O, Kiy...

Ngày tải lên: 07/07/2014, 09:20

... and patients with chronic HCV infection who have cirrhosis stand a very high risk of developing HCC [19] In Japan, HCV infection spread throughout the country mainly in the 1950s and 1960s, and ... their design and in the characteristics of the targeted patients in terms of, for example, disease etiology and severity of background liver diseases Moreover, the reported specificity...

Ngày tải lên: 07/07/2014, 09:20

... choice of therapy, aid in patient counseling, allow comparisons of the end results of therapy, and facilitate patient selection and randomization for research protocols Staging systems for hepatocellular ... and MRI and correlation with pathologic examination of explanted liver J Comput Assist Tomogr 25:327–336 50 Miller WJ, Federle MP, Campbell WL (1991) Diagnosis and staging o...

Ngày tải lên: 07/07/2014, 09:20

... hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre Gut 54:411–418 Chapter Multidisciplinary Care of the Hepatocellular ... multimodality therapy can be expected to challenge our understanding of prognostic factors in HCC References Okuda K, Ohtsuki T, Obata H et al (1985) Natural history of hepat...

Ngày tải lên: 07/07/2014, 09:20

... Liver, Biliary Tract, and Pancreas, 4th edn Elsevier, New York, pp 1269–1277 27 Llovet JM, Bruix J (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization ... including liver resection and liver transplantation, percutaneous ablation therapy as represented by radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI),...

Ngày tải lên: 07/07/2014, 09:20

... widely used human hepatocyte cell line HepG2 (enzyme activity of HepG2 was set at 100%), and the commonly used canine kidney cell line MDCK The results showed the cHCC cell line produced 25% of the ... with the neoplastic nature of the cells [11], and suggests the presence of both fully differentiated hepatocytes and progenitor cells in the cHCC cell...

Ngày tải lên: 13/08/2014, 13:20

... TLR3 INDUCES HEPATOCELLULAR CARCINOMA CELL DEATH AND INCREASES NATURAL KILLER CELL ACTIVITY TOW TINGTING CHARLENE (B.Sc (Hons),NUS) A THESIS ... 1.6 TLR3 expression on tumour cells 22 1.7 The relevance of TLR3 in HCC tumours cells 24 1.8 The Role of TLR3 in Hepatic Cell Death 26 1.9 Natural Killer cells and their relevance to HCC 28 1.10 ... express fun...

Ngày tải lên: 13/10/2015, 16:50