Epithelial mesenchymal transition in breast cancer progression

... the breast 99 Figure 25 Keratin 14 immunostaining in normal breast and skin 107 Figure 26 Keratin 14 immunostaining in DCIS of the breast 108 Figure 27 Keratin 14 immunostaining in IDC of the breast ... keratin 14 overexpression in IDC 110 Figure 29 Maspin immunostaining in normal breast epithelia 118 Figure 30 Maspin immunostaining in DCIS of the breast 119 Figure 31...

Ngày tải lên: 05/10/2015, 21:24

... inhibitory effects of both PPARg ligands (Figure 3C, D, E) Thiazolidinediones inhibit TGF-b1-induced changes in N-cadherin expression independent of PPARg Low basal expression of N-cadherin in ... of inhibition of Smad signaling which could contribute to PPARg- dependent regulation of TGF-b1 responses in A549 cells In addition, PPARg- independent effects of...

Ngày tải lên: 12/08/2014, 11:20

... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... proteins, including CDC42, Par6 and aPKC, did not seem to be involved in the ERp29- induced epithelial morphogenesis These findings demonstrated a novel function and...

Ngày tải lên: 13/10/2015, 15:55

... a cellular level the relationship between progenitor cells and clinicopathological indicators of breast cancer progression, we isolated primary cells from tumour and non -tumour tissue and cultured ... underlying epithelial cells), and cultures containing >30% fibroblasts were discarded In some experiments, primary human mammary epithelial cells (HMEC, Lonza) were cultured in...

Ngày tải lên: 10/08/2014, 10:21

... between blind- and non-blind-performed investigations a-Amylase treatment in human mammary epithelial cells The effect of a-amylase in mammary cells of human origin was studied in primary HBCEC (mammary ... antiproliferative effects in primary rat mammary epithelial cells and human breast tumor cells On the one hand the effects on hea...

Ngày tải lên: 10/08/2014, 10:21

... control (a) Mesenchymal marker F-actin, was faintly stained at the cell margin in the control (c), whereas the staining was substantially enhanced and abundantly located throughout cytoplasm after ... immunofluorescent staining, anti-α-SMA monoclonal antibody (mAb) was purchased from Sigma (reactive with human and mouse α-SMA, Cat A2 547); anti-bovine smooth muscle myosin heavy chain...

Ngày tải lên: 12/08/2014, 16:20

... responsible for their operation should take this guidance into account when planning, commissioning and organising services for cancer patients The recommendations in the guidance concentrate on ... organisations is permitted without the express written permission of the Institute Guidance on Cancer Services Improving Outcomes in Breast Cancer Manual Update Conte...

Ngày tải lên: 14/02/2014, 22:20

... EPIDEMIOLOGICAL GUIDELINES FOR QUALITY ASSURANCE IN BREAST CANCER SCREENING This chapter is the revision of: • Chapter ‘Epidemiological guidelines for quality assurance in breast cancer screening in the ... Pagina 26 EPIDEMIOLOGICAL GUIDELINES FOR QUALITY ASSURANCE IN BREAST CANCER SCREENING Table 11: Screening policy* Age group targeted Scr...

Ngày tải lên: 15/03/2014, 00:20

... orders@intechweb.org Targeting New Pathways and Cell Death in Breast Cancer, Edited by Rebecca L Aft p cm ISBN 978-953-51-0145-1 Contents Preface IX Part Breast Cancer Cell Death Chapter Estrogen-Induced ... Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L Aft Published by InTech Janeza Trdine 9, 51000 Rij...

Ngày tải lên: 23/03/2014, 17:20

... Surprisingly, however, the protein synthesis inhibitor cycloheximide did not abolish the induction, which suggested that GPR30 is directly regulated by progestins We were not able to locate any progestin ... expressed in MCF-7 cells relatively late, although in a progestindependent manner, we decided to investigate whether MAPK activation is responsible for GPR30 mRNA regulation by p...

Ngày tải lên: 24/03/2014, 00:21

... www-dep.iarc.fr/globocan/globocan.html] Jarvandi S, Montazeri A, Harirchi I and Kazemnejad A: Beliefs and behaviours of Iranian teachers toward early detection of breast cancer and breast self-examination ... behaviors and contribute to subsequent delayed presentation of breast cancer in Iranian women [22] The study did not demonstrate any association between age and pat...

Ngày tải lên: 28/03/2014, 14:20

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... serum protein features of a number of cancers in the near future [47] Translational research in breast cancer Breast cancer Breast cancer is the most common malignancy among women in the Western ... Danish Centre for Translational Breast Cancer Research (DCTB), to fight breast cancer DCTB hosts scientists working in various areas of preclinical cancer res...

Ngày tải lên: 30/03/2014, 15:20