FUNCTION AND MECHANISM STUDIES OF TRPV4 IN BREAST CANCER METASTASIS

... Upregulation of TRPV4 protein and mRNA across the BCM model 3.1.4 Upregulation of TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast canc...

Ngày tải lên: 02/10/2015, 17:15

... impact of exercise training on QOL in breast cancer survivors The aim of this study was to assess the association between physical exercise and quality of life in a population of female breast cancer ... between exercise and quality of life in multiple myeloma cancer survivors Support Care Cancer 2004;12:780-8 Courneya KS, Friedenreich CM Physical...

Ngày tải lên: 08/08/2014, 16:23

... cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal objective of this study was to determine the relationship between serum IL-6 and CRP levels and staging and prognosis ... significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients World Journal of Surgical Oncology 2011 9...

Ngày tải lên: 09/08/2014, 01:24

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... types of human cancer However, the mechanism of COX-2 in angiogenesis remains unclear In this study, the data showed that down-regulation of COX-2 could significantly inhibit the in vitro and in ... et al.: The function and mechanism of COX-2 in angiogenesis of gastric cancer cells Journal of Experimental & Clinical Cancer Research 201...

Ngày tải lên: 10/08/2014, 10:21

... robust synthesis of pantothenate from low amounts of pantoate [9] Here, we report the results of the structural studies of the pantoate- bound form of the N-terminal domain of E coli PS (nPS) The structure ... [13] Details of the structural basis for the biochemically observed inhibition of plant PS by pantoate, as well as of the alleviation of...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 23/03/2014, 05:22

... protein–protein interactions [6], as well as in the structural stability of proteins [23–25] Inspection of a preliminary structural model of cyt c6, based on the known structure of cytochrome c6 from ... oxygen of D72 Taking the functionally and structurally interesting mutant D72K as a material starting point, we aimed to study the contribution of the...

Ngày tải lên: 30/03/2014, 20:20

... role of MF in the molting process of the crustaceans [31–33] Therefore, to ascertain the expression of FAMeT in relation to the molting process of the shrimp, we determined the level of expression ... biological function of this gene The refolding of the protein during renaturation is important for the function of the enzyme When we used recombina...

Ngày tải lên: 31/03/2014, 21:21

... Volumetric and Thermodynamic Studies 98 liquid mixtures of weakly7 or strongly interacting components.8 The study of molecular associations in organic ternary mixtures having an alcohol as ... measurements at 303, 308 and 313K The main purpose of this study is to characterize the molecular interactions in these systems and subsequently to determine the...

Ngày tải lên: 07/08/2014, 14:20

... DJ: Assessment of methods for tissue-based detection of the HER-2/ neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry J Clin ... Hospital and Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens...

Ngày tải lên: 09/08/2014, 04:21

... distribution was not In randomised trials and cohort studies, whites were in a minority; in cohorts of SLE patients, they were in the majority Even in randomised trials and cohorts with lupus nephritis, ... occurred in 66% of patients in randomised trials and in 80% in cohorts, a similar proportion given the relatively small numbers Mortality with...

Ngày tải lên: 09/08/2014, 08:23