C erBB2 over expression in invasive breast carcinoma

... immunostaining of invasive ductal breast carcinoma 2+ positive staining 54 C- erbB2 immunostaining of invasive ductal breast carcinoma 3+ positive staining 55 Ductal Carcinoma in situ component of invasive ... cell Myoepithelioma Carcinoid Mesenchymal origin Sarcomas Miscellaneous origin Hematopoietic Metastatic carcinoma 1.2.2.1 Ductal carcinoma in situ (DCIS) Duct...

Ngày tải lên: 02/10/2015, 12:56

... Microscopy pictures illustrating the patterns of HER-2 immunostaining in breast carcinoma Microscopy pictures illustrating the patterns of HER-2 immunostaining in breast carcinoma (a) Weak positive ... importance of HER-2 has also been analyzed in the context of patient subgroups with or without lymph node involvement Most of the studies that have examined the prog...

Ngày tải lên: 09/08/2014, 07:21

... Resisting intrinsic pressures for apoptosis 23 1.6.2 Resisting extrinsic pressures for apoptosis 25 1.6.3 Chemotherapy resistance 27 1.7 Glutathione S- transferase pi (GST -pi) 30 1.8 Scope of study ... analysis 49 2.10 Statistical analysis 50 RESULTS 51 3.1 Glutathione S- transferase pi (GST -pi) expression 52 3.2 Total glutathione S- transferase (GST) activity 55 v 3.3...

Ngày tải lên: 16/09/2015, 17:14

... by these diverse proteins include: altering activity of enzymes, altering affinity between proteins, altering affinity between protein and DNA, altering the metabolism of proteins What effect ... p16 p27 p57 Cmyc Cell Cycle Proteins Figure Percentage of Cell cycle protein expression in the tumor cells X-axis displays: the expression of the cell cycle proteins Cy...

Ngày tải lên: 09/08/2014, 03:21

... gain were detected in at least 30% of both primary tumors and blood (Table 5) Among these, seven regions of copy number gain were found in more than 50% of both primary tumors and blood A gain ... amplified in 90% of the presently studied tumors We identified 46 regions of gain present in more than 30% of the primary tumor samples and 70 regions of gain...

Ngày tải lên: 09/08/2014, 03:21

... lobular carcinoma • Tubulolobular carcinoma Mucinous carcinomas • Mucinous carcinoma • Cystadenocarcinoma • Signet ring cell carcinoma Medullary carcinoma Invasive papillary carcinoma Invasive ... choriocarcinomatous features • Carcinoma with melanotic features Invasive lobular carcinomas • Classical lobular carcinoma • Alveolar lobular carcinoma • Solid lobul...

Ngày tải lên: 13/10/2015, 15:54

... obtained from human invasive ductal breast carcinoma Immunohistochemical analysis showed specific staining for breast tumors: positive staining was detected mostly in primary breast carcinomas and ... polymeric nanoparticles, potent protease inhibitor cystatin and a specific anti-cytokeratin monoclonal IgG, which can be internalized into cells, contributes specific targeting to inv...

Ngày tải lên: 23/03/2014, 07:20

... Pfg27C: 5¢-AAAAAGC TTATGAGTAAGGTACAAAAG-3¢ and 5¢-AAAAAGC TTTTAAATATTGTTGTGATGTGGTTCATC-3¢ (HindIII); Pfg27D: 5¢-AAAGAATTCATGAGTAAGGTACA AAAG-3¢ and 5¢-AAACTGCAGTTAAATATTGTTGT GATGTGGTTCATC-3¢ (EcoRI-PstI); ... Pfg27E:5¢-AAAC TGCAGATGAGTAAGGTACAAAAG-3¢ and 5¢-AAAA GCTTTCACTTCGAATTCCATGGTACCAG-3¢ (PstIHindIII); Pfg27F: 5¢-AAACTGCAGATGAGTAAGGTA CAAAAG-3¢ and 5¢-AAAAAGCTTTTACGACGTTGT GTG...

Ngày tải lên: 23/03/2014, 21:20

... al.: First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity Journal of Translational Medicine ... dose of IMP321 s.c every two weeks for a total of 24 weeks (12 injections in total) The repeated single doses were administered on D2 and D16 of...

Ngày tải lên: 18/06/2014, 16:20

... [41] Interestingly, eIF6 expression was unaltered in EC cells This indicates the complexity of miRNA biosynthesis regulatory mechanisms in EC stem cells and tumours This mechanism is clearly linked ... state In NTera2 cells, differentiation status is confirmed by decreases in expression of Oct4 and Nanog and increases in expression of Afp, Ncam1 and...

Ngày tải lên: 20/06/2014, 07:20

... post-transcriptional level [20] The aim of this study was to investigate the role of p27 and cyclin E immunoexpression as a prognostic factor in early breast carcinoma Methods A database of all wide local excisions ... there were racial differences in breast carcinoma When disease stage and age at diagnosis were adjusted for, it was shown that...

Ngày tải lên: 09/08/2014, 01:24

... function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior ... proliferation, the expression of two host genes, p16INK4a and Akt, were investigated The expression pattern of p16INK4a in dysplastic squamous and glandular cer...

Ngày tải lên: 10/08/2014, 10:21

... exploitation of DDX20 as a potential therapeutic marker for statins and the understanding of the functional relevance of miR-222 to statins- induced apoptosis in invasive breast cancers ix LIST OF TABLES ... identified DDX20 as a crucial player in the metastasis of breast cancers, where DDX20 increases the invasiveness of breast cancers through activati...

Ngày tải lên: 01/10/2015, 17:27

... exploitation of DDX20 as a potential therapeutic marker for statins and the understanding of the functional relevance of miR-222 to statins- induced apoptosis in invasive breast cancers ix LIST OF TABLES ... identified DDX20 as a crucial player in the metastasis of breast cancers, where DDX20 increases the invasiveness of breast cancers through activati...

Ngày tải lên: 03/10/2015, 20:32

... of the AP-2e promoter Sox9 binding to both binding sites (Sox9_ 1 and Sox9_ 2) within the AP-2e promoter was observed in vivo (Fig 5C) Finally, the direct binding of Sox9 to the two Sox9binding ... AP-2e promoter (Sox9_ 1 and Sox9_ 2) Incubation of in vitro-synthesized Sox9 with the labeled oligonucleotides containing the Sox9- binding sites resulted in a stro...

Ngày tải lên: 18/02/2014, 08:20