Anti cancer mechanisms of indirubin 3 monoxime

... 1 .3. 4 Other regulatory mechanisms 30 1 .3. 5 Apoptosis and cancer 30 1 .3. 6 TRAIL signaling pathway as potential therapeutic target 32 Objectives of the study Chapter Materials and Methods 33 34 ... accompanying p 53 up-regulation 51 3. 4 I3M causes Bid cleavage 55 3. 5 I3M induces Bax conformational changes 59 3. 6 I3M induces cytochrome c release 63 v 3. 7 3. 8 Overexpr...

Ngày tải lên: 30/09/2015, 13:41

... A STUDY INTO THE DIFFERENT MECHANISMS OF ANTICANCER EFFECT OF DOCOSAHEXANOIC ACID IN COLON CANCER CELLS MANAV (B MED, GSMU, INDIA) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT ... increased the polyp number in both the small and large intestines, suggesting that fatty acids may activate other pathways also in addition to PPARγ...

Ngày tải lên: 26/09/2015, 09:57

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial...

Ngày tải lên: 10/08/2014, 05:21

... C: Insulin and LiCl prevent down-regulation of cyclin D1 induced by luteolin in HK1 cells Fig 3.7D: Insulin and LiCl abrogate the effects of luteolin on CNE2 cells Fig 4.1: Combined effect of ... during the cell cycle where synthesis of both cyclins B1 and B2 is initiated during the interphase and localised in the cytoplasm During the prophase, cyclin B1 migrates fro...

Ngày tải lên: 10/09/2015, 15:53

... effect 1.1.3.3 Anti- fungal, anti- protozaol and anti- bacterial effects 1.1.3.4 Other pharmacological effects 1.1.4 Anti- cancer potential of AE 1.1.4.1 Anti- mutagenic and anti- carcinogenic effects 1.1.4.2 ... GENERAL DISCUSSION AND CONCLUSIONS 5.1 Anticancer potential of AE: implication of proteomic findings 143 5.2 Anticancer potential of AE: induction of ap...

Ngày tải lên: 12/09/2015, 08:18

... protein-1 Apaf-1 apoptotic protease-activating factor ATM ataxia telangiectasia mutated kinase ATR ataxia telangiectasia and Rad3-related kinase BIM bisindolylmaleimide I CARD caspase recruitment domains ... activated sequentially Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3related kinase (ATR) are activated very rapidly and then activate p53, which eventurely...

Ngày tải lên: 15/09/2015, 17:11

... Abbreviations xv List of Publications xix CHAPTER INTRODUCTION 1. 1 Parthenolide 1. 1 .1 Introduction: feverfew and Parthenolide 1. 1.2 Chemical structure, metabolism and bioactivities of parthenolide 1. 1.2 .1 ... balance 1. 2 .1 Reactive Oxygen Species 17 1. 2 .1. 1 Definition 17 1. 2 .1. 2 Sources of ROS 18 1. 2.2 Biothiols 19 1. 2.2 .1 Definition 19 1. 2.2.2...

Ngày tải lên: 16/09/2015, 17:14

... focused on the anti- inflammatory activity of parthenolide On the other hand, the anti- cancer potential of parthenolide has rarely been studied Thus, the main objective of this study is to further ... investigate the anti- cancer potential of parthenolide by studying its sensitization effects on cancer cells in response to death receptor ligands To...

Ngày tải lên: 16/09/2015, 17:14

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... matrine, supporting the further development of this novel delivery system for cancer therapy Materials and Methods Preparation of RGD-modified long circulating liposome (LCL) loading matrine (RGD-M-LCL) ... when the liposomes were reconstitutes in solvent Because matrine is a strongly hydrophilic and weakly alkaline drug, the encapsulation efficiency of liposomes for...

Ngày tải lên: 26/10/2012, 08:57

... Schuurman AG, Goldbohm RA, Brants HA, van den Brandt PA: A prospective cohort study on intake of retinol, vitamins C and E, and carotenoids and prostate cancer risk (Netherlands) Cancer Causes ... cancers of the mouth and pharynx, esophagus, lung, stomach, and colon and rectum; evidence of probable risk reduction was found for cancers of the larynx, pancreas, bre...

Ngày tải lên: 06/03/2014, 02:21

... is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... limited number of cytokines that inhibit the adhesiveness, growth and migration of cancer cells The most intriguing finding of the present study was that the functio...

Ngày tải lên: 18/06/2014, 19:20

... al.: Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer Journal of Translational Medicine 2011 9:133 Submit your ... factor; mTOR: Mammalian target of Rapamycin; PI3K: phospahtidylinositol-3 kinase; RCC: renal cell carcinoma; RTK: receptor tyrosine kinase; and T...

Ngày tải lên: 18/06/2014, 22:20