mechanisms of dominant cancer susceptibility

... DIFFERENT MECHANISMS OF ANTICANCER EFFECT OF DOCOSAHEXANOIC ACID IN COLON CANCER CELLS MANAV (B MED, GSMU, INDIA) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF COMMUNITY, ... 2.11 Measurement of ROS 32 CHAPTER III: EFFECT OF DHA ON VIABILITY OF COLON CANCER CELLS 3.1 Introduction 34 3.2 Results 35 3.2.1 Cytotoxic effects of PUFAs 35 3.2.1.1 Effect of different fatty ... against colon cancer However the mechanisms of the anti -cancer effects of n-3 PUFAs have not been fully elucidated Docosahexanoic acid (DHA) (22:6, n-3), abundantly found in fish oil, is one of the...

Ngày tải lên: 26/09/2015, 09:57

... breast cancer However, her family history was negative for colon cancer, endometrial or ovarian cancers, thyroid cancer, or any other cancers The patient recollected that her husband, who died of ... history of breast neoplasms in our patient further suggests an increased susceptibility to cancer Breast cancer is the most common cancer in women and has been associated with a number of specific ... elucidation of the role of SVs in cancer susceptibility syndromes lacking identifiable genetic mutations 10 11 12 13 14 We speculate that this patient’s clustering of neoplasms represents a novel cancer...

Ngày tải lên: 11/08/2014, 17:21

... understanding and support ii TABLE OF CONTENTS Title page i Acknowledgements ii Table of contents iii Summary vii List of Publications viii List of Figures ix List of Tables xi List of Abbreviations xii Chapter ... of the study The main objective of this project is to study the molecular mechanisms involved in the anti -cancer effect of I3M, focusing on the apoptotic pathways involved The specific aims of ... apoptotic cell death First, the cytotoxicity of I3M in three different types of human cancer cells was confirmed — cervical cancer- HeLa, hepatoma-HepG2 and colon cancer- HCT116 through flow cytometry...

Ngày tải lên: 30/09/2015, 13:41

... based on a first pass of signal-noise ratio of and a minimum peak threshold of 20% of all spectra This process was completed with a second pass of peak selection at 0.2% of the mass window, and ... Genetic models of human cancer as a multistep process Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia J Exp Clin Cancer Res.2005; ... (AIHW), Australasian Association of Cancer Registries (AACR) Cancer in Australia In: Cancer in Australia 2001; Cancer series number 28 Canberra: Australian Institute of Health and Welfare 2004: 6-25...

Ngày tải lên: 25/10/2012, 11:18

... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of ... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells ... calculated according to the formula: Changes in the level of phosphorylated JNK 1&2 (-fold of control) = absorbance of treated cells / absorbance of control cells All points were done duplicate X three...

Ngày tải lên: 31/10/2012, 15:12

... vacuum-UV photolysis of water (H2O-VUV) is still a field of active research compared to other AOPs (Oppenlander and Gliese, 2000) The special requirements of the VUV photolysis of water according ... related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, 1995) within a photochemical reaction zone of less than 0.1 mm (Heit ... differentiation of the contributions on the decomposition of Re 141 in aqueous solutions by UV direct photolysis, OH generated from the excitement of water, oxygen, and H2O2, respectively Development of the...

Ngày tải lên: 05/09/2013, 09:08

... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... measurement, considering of their respective analytical errors A concept of two-component mixing was employed, in which it was assumed that runoff is composed of a mix of two components: one originating ... and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig...

Ngày tải lên: 05/09/2013, 09:08

... some of PAOs can that, the inhibitory effect of nitrite will be reduced Hence, the purpose of this study is to examine the effect of anoxic activity of PAOs on reduction of inhibitory effect of ... Cycle Operations of SBRs for Cultivation of the Enriched PAOs - 66 - Journal of Water and Environment Technology, Vol 6, No.1, 2008 Table - Composition of Synthetic Wastewater Methods of nitrite inhibition ... presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the size of inhibition...

Ngày tải lên: 05/09/2013, 09:38

... cycle soon followed Transmission Mechanisms of Monetary Policy Traditional Interest-Rate Channels: expansionary monetary policy ir ↓, I ↑, Y↑ The interest rate channel of monetary transmission applies ... price for it relative to the cost of the facilities and equipment they are buying I ↑ because firms can buy a lot of new investment goods with only a small issue of stock The transmission mechanism ... which raises the desire of consumers to hold durable goods or housing, thus ↑ spending on them Expansionary monetary policy Pe ↑, value of financial assets ↑, likelihood of financial distress ↓,...

Ngày tải lên: 05/01/2014, 17:01

... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may influence a woman's decision to...

Ngày tải lên: 13/02/2014, 06:20

... blocks only after partial unfolding of the a-helix from the body of the b-sheet (Fig 2C) Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... understanding of the importance of different parts of the molecule and their flexibility in the process of amyloid fibril formation often results more from a structural analysis of the amyloid ... absence of structural restraints is considered to drive the assembly of susceptible proteins into amyloid fibrils [19] The structure of amyloid fibrils reflects the aggregation of strands of b-pleated...

Ngày tải lên: 14/02/2014, 18:20

... presence of colorectal cancer using serum, stool and urine Definition of colon cancer: Cancer that forms in the tissues of the colon (the longest part of the large intestine) Most colon cancers ... on Biomarkers of Early Cancer and Cancer Risk One of the most consistent properties of lung cancers is their high level of chromosome instability that is reflected in imbalance of chromosome ... Colorectal Cancer Colon cancer is the third most frequently diagnosed cancer in the United States and the third most frequent cause of cancer death Successful prevention of deaths from colorectal cancer...

Ngày tải lên: 14/02/2014, 21:20

... 2008.11,12  management of cervical cancer 1.2 remit of the guideline This guideline will cover presentation, referral, diagnosis, staging and treatment of cervical cancer The management of small cell ... management of cervical cancer 12.3 THROMBOTIC and bleeding problems Patients with advanced cervical cancer are at risk of both thrombosis and haemorrhage as a consequence of their cancer or metastatic ... support needs of cancer patients was from small heterogeneous studies and the types of help offered are very varied.238-240 None of the studies was specific to patients with cervical cancer but...

Ngày tải lên: 14/02/2014, 22:20

... women, respeccancer was assessed by means of a comparison of the rates of the tively The rates of occurrence of tumors of 2.1–3.0 cm were occurrence of that disease during each of the first yearly ... each of them received information about the potential number of breast cancer and coronary artery cases that might be prevented from the use of tamoxifen, as well as the number of cases of endometrial ... Fig Example of a breast cancer risk profile NSABP ‫ ס‬National Surgical Adjuvant Breast and of breast cancer and was not included in the Bowel Project; UNK ‫ ס‬unknown (Reproduced from Cancer Control...

Ngày tải lên: 15/02/2014, 04:20

... profiles of the four histopathological subtypes of lung cancer cells in relation to gene networks and statistical analysis would be a valuable and meaningful undertaking Because the analysis of ... Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH: A genetic explanation of Slaughter’s concept of field cancerization: evidence and clinical implications Cancer Res 2003, 63:1727-30 Inamura K, Fujiwara ... K, Lee S: Clinical validity of the lung cancer biomarkers identified by bioinformatics analysis of public expression data Cancer Res 2007, 67:7431-8 Schwarte-Waldhoff I, Klein S, Blass-Kampmann...

Ngày tải lên: 15/02/2014, 04:20

... Proton ATPasePump Inhibition of acidification of phagosome harbouring Mycobacteria Expression of virulence proteins of PE-PGRS family C O2– Fig Key factors of the survival mechanisms involved in the ... of digested material by exocytosis Fig Detailed structure of a macrophage showing a typical process of phagocytosis Engulfed material A D Phagosome TACO Fusion Lysosome Inhibition of fusion of ... proteins of mycobacteria have a profound influence on its pathogenicity It was found that the disruption of an erp gene of M tuberculosis encoding a secretory protein effects the survival of M tuberculosis...

Ngày tải lên: 16/02/2014, 15:20

... with an increased risk of T2DM, hypertension and CVD; however, the exact underlying pathophysiological mechanisms by which obesity increases the risk of VD remains the subject of intensive investigation ... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... organic ED, in which approximately 43% of men with MetS had ED and the severity of ED increased with the components of the MetS [84] Interestingly, the severity of ED was positively associated with...

Ngày tải lên: 18/02/2014, 06:20

... deprotonation of C2a-OH of HEThDP and protonation of FAD at N5 and N1) The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron and ... radical An additional intricacy of this mechanism is the necessity of a structural rearrangement of CoA in the course of catalysis: initially, the reactive thiol group of CoA must be positioned proximal...

Ngày tải lên: 18/02/2014, 08:20

... of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 catalysis came from experiments with metalloporphyrin models [5,6,77] Of ... of the crystal structure of NDO as well as spectroscopic data provide a rationale for the catalytic mechanism of this class of enzymes Naphthalene 1,2dioxygenase is a heterohexamer composed of ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse...

Ngày tải lên: 19/02/2014, 16:20

... Development of displays and workstation design for improved image interpretation Discovery of molecular profiles toward goal of precise molecular diagnosis of cancer Breast cancer is one of eight cancers ... detection of breast cancer / Committee on the Early Detection of Breast Cancer ; Sharyl J Nass, I Craig Henderson, and Joyce C Lashof, editors ; National Cancer Policy Board, Institute of Medicine ... being developed, including culture of breast cancer cells in the laboratory, measurement of protein expression in cancer cells, identification of markers of cancer cells or the proteins that they...

Ngày tải lên: 05/03/2014, 12:20