mechanisms of castration resistant prostate cancer

... metastasis derived from prostate cancer Lymph node metastasis derived from prostate cancer Bone metastasis derived from prostate cancer Bone metastasis derived from prostate cancer ATCC Antibodies ... (3) Figure 1: Prostate cancer diagnosis world wide The most commonly diagnosed cancer among men worldwide in 2008 Prostate cancer (purple) is the second largest cause of death in men of the western ... Identification of novel therapeutic targets for castration resistant prostate cancer by whole exome sequencing, and functional validation of the identified targets   24     List of Abbreviations...

Ngày tải lên: 19/11/2015, 14:04

... high-dose exogenous testosterone in patients with castration- resistant metastatic prostate cancer Patients with progressive castration- resistant prostate cancer who had been castrated for at least yr ... causes regression of primary and metastatic prostate cancer [1] Approximately 20-40% of patients treated with radical prostatectomy will have tumor recurrence and elevation of serum prostate- specific ... the production of prostate- specific antigen (PSA) in prostate cells [15,16] Based on gene microarray studies of seven different human prostate cancer xenograft models, an increase of AR mRNA was...

Ngày tải lên: 10/08/2014, 10:20

... descriptors Gater et al Health and Quality of Life Outcomes 2011, 9:88 http://www.hqlo.com/content/9/1/88 Page of 11 Castration Resistant Prostate Cancer (CRPC) Treatment Side Effects Signs & ... Breakthrough cancer pain; CIPN: Chemotherapy-induced peripheral neuropathy; CRPC: Castration- resistant prostate cancer; FDA: Food and Drug Administration; HRQL: Health-related quality of life; IMMPACT: ... patterns of prostate cancer: an autopsy study of 1,589 patients Hum Pathol 2000, 31:578-583 Hering F, Rodrigues PR, Lipay M: Clodronate for treatment of bone metastases in hormone refractory prostate...

Ngày tải lên: 12/08/2014, 00:20

... Functional Assessment of Cancer Therapy, Prostate Cancer Version (FACT-P), the Brief Pain Inventory- Short Form (BPI), and the Schwartz Cancer Fatigue Scale (SCFS) FACT-P consists of 27 core items, ... A patients on day of cycles 2, 4, and as well as completion of treatment; for Arm B patients, on day 22 of cycle and day of cycles and and completion of treatment In the case of missing responses ... therapy Page of 9 10 11 12 13 14 Author details Department of Medicine, The Cancer Institute of New Jersey, UMDNJRWJMS, New Brunswick NJ, USA 2Department of Biostatistics, Dana Farber Cancer Center,...

Ngày tải lên: 18/06/2014, 16:20

... Fleisher M, Sawyers CL, Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium: Antitumour activity of MDV3100 in castration- resistant prostate cancer: a phase 1-2 ... persistence of both AR and tissue androgens in recurrent prostate cancer, therapies that directly target the AR, or affect the persistence of androgens in prostate tissue, Page of may be of value ... overexpression of androgen receptor gene in hormone-refractory prostate cancer Cancer Res 2001, 61:3550-3555 Mostaghel EA, Nelson PS: Intracrine androgen metabolism in prostate cancer progression: mechanisms...

Ngày tải lên: 10/08/2014, 21:23

... study was performed as a pilot substudy of an open-label phase trial of Alpharadin in patients with bone metastases and castration- resistant prostate cancer Repeated 18F-fluoride PET imaging, ... References Prostate cancer - UK incidence statistics [http://info.cancerresearchuk.org/ cancerstats/types /prostate/ incidence/#geog] Rubens RD: Bone metastases - incidence and complications In Cancer ... pilot study has shown the feasibility of measuring changes in the uptake of 18 F-fluoride with PET in patients with bone metastases from prostate cancer Page of receiving systemic therapy with 223Ra-chloride...

Ngày tải lên: 21/06/2014, 02:20

... variations in prostate positioning [12,13] Variables with the potential to influence prostate motion are an important aspect of clinical research in the delivery and treatment of prostate cancer The ... consisted of patients treated with external beam radiation for prostate cancer Two common types of radiation treatments were studied, pelvic radiation followed by a cone down to the prostate and prostate ... radiation treatment of prostate cancer: Can the use of a bladder ultrasound scanner and biofeedback optimize bladder filling? Int J Radiat Oncol Biol Phys 2006, 65:371-377 Page of (page number not...

Ngày tải lên: 09/08/2014, 10:20

... width of 11 mm, a pitch of 0.5, modulation factor of and a dose calculation grid of approximately × × mm3 was used [30] Figure Pelvic Target; Normal Tissue Bladder and Rectum Prostate and Prostate/ Seminal–Vesicles ... treatment of the prostate gland is based on currently available data The reliability of each radiobiologic model will limit our BED However, even if the α/β of prostate is instead of 1.5, our ... rest of the pelvis The clinical impact of this difference in terms of acute and late effects is currently unknown Unfortunately, there are no defined dose limits to OARs in the setting of hypofractionated...

Ngày tải lên: 09/08/2014, 10:21

... reaction (Patients with non -prostate cancer (NonPCa)-1, Patients with prostate cancer (PCa)-1) are shown (C) Two samples that showed positive reaction from patients with prostate cancer (PCa-2 and -3) ... The percentages of GFP-positive cells were measured using CellQuestPro software [14] Western blot analysis For Western blot analysis of XMRV proteins, cell lysates of prostate cancer (PC-3) cell ... prostate tissues (110 PCa and 40 benign/normal controls) One out of 40 high grade PCa (Gleason score 8-10), out of 70 intermediate grade PCa (Gleason score 5-7), and out of 40 benign/normal prostate...

Ngày tải lên: 13/08/2014, 01:20

... age of ten in group NA than in group A This proportion increased from 68.3% at the age of three to 87.3% at the age of ten for group NA, and from 62.5% at the age of three to 66.7 at the age of ... study At the age of seven, all of them still living in the region were included in a follow-up of their computerised medical records, which were examined for the occurrence of the diagnosis asthma ... obtained by investigations of the maternal medical records at the University Hospital, including PHC data of the statements made by the mid-wife in her records of the check-up of the mothers during...

Ngày tải lên: 26/10/2012, 09:48

... 64 of 75 patients who had completed the Functional Assessment of Cancer Treatment -Prostate (FACT-P) questionnaire as part of a Phase II trial of cryosurgery as primary therapy for localized prostate ... Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized Prostate Cancer ... application of cryosurgical ablation of the prostate Technol Cancer Res Treat 2007; 6: 97 30 Gage AA and Baust JG: Cryosurgery of tumors J Am Coll Surg 2007; 205: 342 31 Hoffmann NE and Bischof JC:...

Ngày tải lên: 28/03/2014, 23:20

... study of tomato products, lycopene, and prostate cancer risk J Natl Cancer Inst, 94: 391, 2002 Yu, H., Harris, R E., Gao, Y T., Gao, R and Wynder, E L.: Comparative epidemiology of cancers of the ... disease is the leading cause of death of men and women in the United States and either the primary or secondary cause of death of most men with prostate cancer, and obesity is of widespread concern ... Crutchfield, L., McCorman, P et al: A qualitative analysis of interviews of men with early stage prostate cancer: the Prostate Cancer Lifestyl Trial Cancer Nurs., 28: 99, 2005 Daubenmier, J., Weidner,...

Ngày tải lên: 29/03/2014, 01:20

... protein signature of prostate cancer biopsies revealed the overexpression of TPD52 in cancer patient material [22] To date, the main physiological role of TPD52 in prostate cancer progression ... in prostate cancer development and progression [21] Because the precise mechanism of the function of TPD52 in prostate cancer progression is still under investigation, the main objective of the ... human prostate cancer progression Clin Cancer Res 13, 6040–6048 Hullinger TG, McCauley LK, DeJoode ML & Somerman MJ (1998) Effect of bone proteins on human prostate cancer cell lines in vitro Prostate...

Ngày tải lên: 30/03/2014, 02:20

... characteristic of the MRP1-mediated efflux of PIRA However, further depletion yielded a decrease of the ratio Effect of cholesterol depletion on the rate of MRP1-mediated efflux of GSH Fig Incorporation of ... increase of the rate of PIRA passive uptake In order to determine an eventual impact of MbCD on the rate of MRP1-mediated efflux of PIRA, experiments were performed with energy-depleted resistant ... function of the time of incubation of cells with PIRA The active efflux rate (Va) was determined from dF ⁄ dt after the addition of glucose Va° and V MbCD are the rates of MRP1-mediated efflux a of PIRA...

Ngày tải lên: 30/03/2014, 09:20

Ngày tải lên: 01/04/2014, 13:20

... of detecting prostate cancer, and it can signal the presence of cancer in individuals who display no symptoms of prostate abnormalities This test measures the level of a glycoprotein called prostate- speciÞc ... AMERICAN April 1994 71 The Dilemmas of Prostate Cancer Do the risks of aggressive treatment for early prostate cancer outweigh the benefits? This question is one of several unresolved issues faced ... Dilemmas of Prostate Cancer Marc B Garnick PROSTATE A common cause of death among men, this cancer has been detected with increasing frequency in recent years Questions about the eÝectiveness of therapy...

Ngày tải lên: 12/05/2014, 14:54

... overexpressed in a variety of tumor tissues, including prostate cancer AMACR was identified as a tissue biomarker for prostate cancer by gene expression profiling of primary human prostate cancer and benign ... from PBMCs of HLA-A24-positive prostate cancer patients AMACR1 peptide-specific CTL induction from PBMCs of HLA-A24-positive prostate cancer patients PBMCs of HLA-A24-positive prostate cancer patients ... from PBMCs of HLA-A24-positive prostate cancer patients AMACR2 peptide-specific CTL induction from PBMCs of HLA-A24-positive prostate cancer patients PBMCs of HLA-A24-positive prostate cancer patients...

Ngày tải lên: 18/06/2014, 15:20

... human prostate tumors [1] Although initial studies supported the presence of XMRV in prostate cancer tissues [2-4], since then several laboratories have failed to detect the virus in cohorts of prostate ... XMRV infects and replicates efficiently in prostate cancer cells of epithelial origin It has been proposed that due to lack off or very low levels of A3G protein XMRV is able to productively ... are substantially lower than A3G and detection of A3A/A3C/A3H in the A3G band are highly unlikely Figure Detection of A3G in prostate cancer cells of epithelial origin A3G was detected using two...

Ngày tải lên: 18/06/2014, 18:20

... patients with benign conditions Cancer/ testis antigens are by far the most cancer- specific TAA, which are shared by a number of solid tumors including prostate cancer, lung cancer, and so on In normal ... patients with lung cancer and colon cancer, two common cancers for elder men will also be included in the crossvalidation in order to enhance the prostate cancer specificity of the assay Once ... multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness Cancer Epidemiol Biomarkers...

Ngày tải lên: 18/06/2014, 19:20

... effect of MDA-7 on prostate cancer cells Studies of adenoviral vectorinduced expression of MDA-7 in human prostate cancer cells demonstrated varying degree of inhibition of growth and induction of ... Over-expression of TGase-4 in prostate cancer cells diminishes the action of MDA-7/IL-24 in prostate cancer cells -Adhesion assays Effects of TGase-4 and MDA-7 on the growth of prostate cancer cells We first ... MDA-7 and TGase-4 in prostate cancer cells and tissues In the course thereof, we have further found that the effect of MDA-7 on prostate cancer cells is dependent on the presence of TGase-4 in the...

Ngày tải lên: 18/06/2014, 19:20