GDNF receptor complex in neuronal differentiation and breast cancer

... 1.3 GDNF receptor complex in neuronal biology Since the discovery of the roles of GDNF in promoting survival and differentiation of midbrain dopaminergic (DA) neurons and increasing the affinity ... NT2 into specific neuronal lineages and study the roles of GDNF receptor system in neuronal differentiation and neuronal lineage specification 38 CHAPTER GDN...

Ngày tải lên: 30/09/2015, 10:11

... pathways involved in the activation of specific proteins, mRNAs and miRNAs through combinatorial interactions of GFLs, GFRα and RET receptor isoforms and provides novel insights into the diverse functions ... ligand receptor systems and microRNAs during neuronal differentiation of NTera2 neuroprogenitor cells (Chapter 8) The findings in this thesis further...

Ngày tải lên: 09/09/2015, 10:13

... signaling Figure 1.2 Outline of miRNA biogenesis and action Figure 1.3 Involvement of miRNAs in control of neuronal differentiation Figure 2.1 Overview of gene expression during neuronal ... dendritic spines [71] and synapse activity [72] Figure 1.3 Involvement of miRNAs in control of neuronal differentiation miR-9 and miR-124 promote neuronal differentiation by re...

Ngày tải lên: 26/09/2015, 10:51

... model 85 4.2 Temporal and spatial expression of nm23- M2 gene 85 4.3 The role of nm23- M2 in dopaminergic MN9D differentiation 87 4.4 The role of nm23- M2 in inducing cell cycle arrest 89 4.5 Further ... MN9D 64 cell differentiation 3.2 3.1.4 Spatial expression of nm23- M2 in MN9D and SH-SY5Y cells 66 3.1.5 Subcellular localization of nm23- M2...

Ngày tải lên: 08/11/2015, 17:09

... the concept of relying on age or menopausal status in surgical decision making Postmenopausal breast cancer cases in developing countries have their concerns about body image and they have the ... Farrar W, Andersen BL: Comparing Surgical Groups and Determining Individual Differences in Postoperative Sexuality and Body Change Stress J Consult Clin Psychol 2000, 68(...

Ngày tải lên: 09/08/2014, 04:21

... from synovia from OA and RA patients Discussion The novel finding of the present study is the identification of the key components of the cannabinoid receptor system in the knee synovia of patients ... levels of PEA were similar in the synovial fluid of OA and RA patients Thus, levels in the synovial fluid not simply reflect the leve...

Ngày tải lên: 09/08/2014, 10:23

... NGF expression by staining on a single cell level using flow cytometry Concomitant staining of cell surface markers and intracellular NGF revealed the presence of NGF in T lymphocytes (CD3+) and ... Figure NGF staining by flow cytometry PBMC of (a) healthy controls (HC) and (b) synovial fluid mononuclear cells (SFMC) from spondyloarthritis (SpA), cytometry and (c) rheumatoid ar...

Ngày tải lên: 09/08/2014, 14:21

... we investigated the functional regulation of GABAB receptors and GAD in hypoxic neonatal rats and the role of glucose, oxygen and epinephrine in altering the receptor status Numerous studies by ... expression of GABAB receptor and GAD in the brain stem and cerebellum The GABAB receptor was significantly decreased in epinephrine...

Ngày tải lên: 10/08/2014, 05:21

... JHK, and PH participated in its design and coordination and helped in the acquisition of clinical data TD initiated the study, participated in the analysis and interpretation of data, and drafted ... allele Altogether, we find no general association of the TOPBP1 Arg309Cys variant with breast cancer risk, and the direction of the marginally significant association...

Ngày tải lên: 11/08/2014, 07:21

... hyperfunctioning commonly involving the pituitary, adrenal, and thyroid glands, as well as myxomas (skin, heart, and breast) and lentiginosis in select areas of the Table Incidence of Internal Malignancies ... Discussion Our patient presented with multiple malignant neoplasms including sebaceous gland carcinoma, papillary thyroid carcinoma, and breast can...

Ngày tải lên: 11/08/2014, 17:21

... study was to examine the expression of LIF and of its specific receptor gp190 in human liver Results obtained with immunostaining of liver sections led us to examine LIF expression by cultured liver ... of LIF secretion by interleukin-4 Regulation of LIF secretion by interleukin-4 Confluent cultures of human liver myofibroblasts were cultured in...

Ngày tải lên: 13/08/2014, 13:20

... repression of genes involved in central carbon metabolism and purine/pyrimidine biosynthesis in B subtilis was said to occur independently of relA, and, therefore, presumably also of ppGpp synthesis, in ... proteome/transcriptome analysis of the response of Bacillus subtilis to ppGpp synthesis induced in exponentially growing cells by addition of the leucyl- and...

Ngày tải lên: 14/08/2014, 08:20

... The role of IKKalpha, IKKbeta and NF-kappaB in the progression of breast cancer Lindsay Bennett BSc(Hons), MSc Submitted in fulfillment of the requirements for the degree of PhD Institute of ... 16% of familial breast cancers not being linked to either of these genes [23] Mutations in both BRCA1 and BRCA2 also increase the risk of ovarian c...

Ngày tải lên: 22/12/2014, 21:49

... Despite the availability of therapies targeting estrogen and growth factor signaling pathways, the incidence and mortality of breast cancers have not decline at the same rate as other major causes of ... 36 1.8 Icaritin and cancer cell proliferation 1.8.1 Icaritin and cancer cell proliferation Herba Epimedii is officially listed in China as an herb that p...

Ngày tải lên: 04/10/2015, 17:05

... factors according to age at diagnosis Risk factor Age at menarche early breast cancers late breast cancers Age at first full-term pregnancy early breast cancers late breast cancers (n) studies ... Fig Relation between parity and risk of (a) early breast cancer and (b) late breast cancer Table Summary of the results on the relationship between breast ca...

Ngày tải lên: 05/03/2014, 17:20