Novel CNS gene delivery systems

... 2.1 CNS gene delivery systems 2.2 Nonviral gene delivery systems 2.2.1 PEI mediated gene delivery 2.2.1.1 PEI chemistry 2.2.1.2 PEI as an efficient gene ... vectors commonly used in CNS gene delivery will be reviewed 2.2 Nonviral gene delivery systems Nonviral gene delivery systems can be categorized into three groups: 1) naked DNA delivery facilitate...

Ngày tải lên: 16/09/2015, 15:54

... enables them to serve as "Trojan horses" for the delivery of genes for cancer therapy Indeed, clostridial spores that were genetically manipulated to harbour genes for cancerstatic factors, prodrug ... these vectors (Table 1) Advantages of clostridial spores as "trojan horse" vectors for cancer gene therapy At present, there are various gene therapy vector sy...

Ngày tải lên: 14/08/2014, 19:22

... densities up to 3.5 Tb/in2 [43] 1.7 Heat- Assisted Magnetic Recording The concept of heat- assisted magnetic recording (HAMR) is similar to the concept of magneto-optical recording proposed by Katayama ... by thermal fluctuations but is prevented by an energy 11 barrier given by the product of the magneto crystalline energy and the volume of the magnetic...

Ngày tải lên: 09/09/2015, 08:17

... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery...

Ngày tải lên: 25/10/2013, 08:20

... served as cold or hot beverages Homemade chicken soup has always been perceived to be healthful.28 Before the concept of nutraceuticals was introduced, chicken soup competed with wine and yogurt for ... can be formulated to produce nutraceutical drinks is unlimited Sport beverages have a special purpose and for that reason may not be thought of as Þrst-line nutraceutical bevera...

Ngày tải lên: 25/10/2013, 21:20

... shopping for HDSL, T1 and Optical DS2 service delivery solutions Eliminates multiple vendors’ products • Permits migration from copper-based services to fiber-based services within the same common ... Ont (905) 629-3104 • Ottawa, Ont (613) 599-5729 The Lowest Total Cost Solution SONEPLEX T1-BASED SERVICE DELIVERY SYSTEMS 418 6/98 Revision © 1997, 1998 ADC Telecommunications, Inc A...

Ngày tải lên: 10/12/2013, 16:15

... the surface of PLGA NPs [62] These polymers have been designated as feasible candidates for drug delivery systems, anti -cancer agents and vaccine immunotherapy For example, DNA vaccine delivery ... doi:10.1186/1476-4598-10-3 Cite this article as: Bolhassani et al.: Improvement of different vaccine delivery systems for cancer therapy Molecular Cancer 2011 1...

Ngày tải lên: 06/03/2014, 02:21

... for the Myc tag included in the molecule, further conrming the identity of the recombinant protein (Fig 1B) Recombinant HMGB21 86 binds to plasmid DNA and cell surfaces Binding of HMGB21 86 protein ... SV40NLS -HMGB21 86 mediate gene transfer To examine the gene- transfer activity of HMGB21 86 fusion proteins, proteinDNA complexes were prepared by mixing increa...

Ngày tải lên: 16/03/2014, 22:20

... (2004) Physicochemical optimisation of plasmid delivery by cationic lipids J Gene Med 6, S24 S35 15 Wasungu L & Hoekstra D (2006) Cationic lipids, lipoplexes and intracellular delivery of genes ... diameter around lm Use of DOPE and cholesterol to enhance the genedelivery properties of cationic lipids has been extensively documented [1621] For 1,3lb2 and 1,3lb3, tr...

Ngày tải lên: 23/03/2014, 07:20

... Chemical Aspects of Drug Delivery Systems Chemical Aspects of Drug Delivery Systems Edited by D R Karsa Akcros Chemicals UK Ltd., Manchester R A Stephenson Chemical Consultant ... solubility and stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMIN...

Ngày tải lên: 28/03/2014, 10:20

.. . Cole-Strass, A., Yoon, K., Xiang, Y. , Byrne, B.C., Rice, M.C., Gryn, J., Holloman, W.K & Kmiec, E.B (1996) Correction of the mutation responsible for sickle cell anemia by an RNA- DNA oligonucleotide .. . chimeric RNA/ DNA oligonucleotides Nat Med 4, 285–290 28 Kren, B.T., Parashar, B., Bandyopadhyay, P., Chowdhury, N.R., Chowdhury, J.R & Steer, C.J (1999) Correct...

Ngày tải lên: 31/03/2014, 08:20

... On the completion of this course, the student should be able to have a deep understanding of the chemical aspects of drug delivery systems that have recently attracted attention from the chemistry ... Society of Chemistry, American Chemical Society, Wiley InterScience journals… CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polym...

Ngày tải lên: 18/04/2014, 15:37