Molecular function and regulation of the bax associating protein MOAP 1
Molecular function and regulation of the bax associating protein MOAP 1
... MOLECULAR FUNCTION AND REGULATION OF THE BAX- ASSOCIATING PROTEIN MOAP- 1 Fu Nai Yang INSTITUTE OF MOLECULAR AND CELL BIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2007 MOLECULAR FUNCTION AND REGULATION ... pore 35 1. 3.3.3 Channel formation 38 ii 1. 4 THE MULTIDOMAIN PRO-APOPTOTIC PROTEIN BAX AND BAK 41 1.4 .1 Bax plays dominant role over Bak 41...
Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... in protein protein interaction are blue and the dehydrogenase domains of Tic3 2 and Tic6 2 are shown in green Tic1 10 contains two transmembrane domains at the proximal N-terminus The topology of ... surprising to find proteins with redox-active domains as Tic constituents Up to now, the ‘regulon’ of the Tic complex comprises three proteins: Tic6 2, Tic3 2...
FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE
... sometimes 2.1 Orofacial pain Orofacial pain is defined as pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders ... revealed that pain is one of the main reasons that patients look for medical attention and that the lifetime prevalence of pain indications such as back pain,...
Characterization of the function and regulation of cullin ring e3 ubiquitin ligases
... characterized is the Cullin RING E3 ubiquitin ligases 1.5 Cullin RING E3 Ubiquitin Ligases Cullins form an evolutionarily conserved gene family They were first discovered as mediators of ubiquitin dependent ... promoting the binding of CAND1 to the CRL complex (Cope and Deshaies, 2003; Bosu and Kipreos, 2008) CAND1 only binds to the unneddylated form of...
Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... endocannabinoid system, we investigated the presence and regulation of endocannabinoids, cannabinoid receptors and FAAH in immature and mature dendritic cells obtained by stimulation with either the ... min), two fractions were obtained: a top leukocyte band containing mononuclear cells (monocytes and lymphocytes) and a lower band containing polymorphonuclear le...
Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... 3 1 1 1 1 )4 71, +467 )4 71 )4 71, )1 16 )3 96 )3 48 )3 48 )3 18, +109, +201 )2 67 )2 19, )1 38, +206 )1 53 )5 3 )5 2 )5 2 +222 +260 +423 +465 +466 a Numbers refer to the position of the 5¢-end of the conserved ... throughout the brain tissue in R6/1 compared to R6/2 mice [29,30] The differences between the two transgenic line...
Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx
... distribution of FEBS Journal 278 (2011) 319 0–3 203 ª 2011 The Authors Journal compilation ª 2011 FEBS 3193 Function and regulation of ABCA1 K Nagao et al Table Effects of mutations on the functions of ABCA1 ... re-secreted The internalized ABCA1 and apoA-I were reported to co-localize within late endosomes, and ABCA1 rapidly 3194 Fig Membrane meso-domain orga...
Báo cáo khoa học: Molecular cloning and characterization of the crustacean hyperglycemic hormone cDNA from Litopenaeus schmitti Functional analysis by double-stranded RNA interference technique pot
... expression of L schmitti CHH gene The size and expression of the CHH mRNA in different tissues were determined by northern blot analysis of total RNA isolated from eyestalk, muscle and stomach ... interference RNA in vivo, for example, the length of target mRNA, the length and concentration of dsRNA, the region of homology between the dsRNA and t...
Báo cáo khoa học: Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase pptx
... vascular endothelium [11], cartilage [12], and other peripheral tissues, and plays a variety of local regulatory roles The physiological and pathophysiological roles of natriuretic peptides and receptor ... [86] Nevertheless, the observed homodimerization of the GCD and the metal ion dependence of the catalytic activity support the integrity of the expres...
Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
... values TGF-b1 signalling was affected similarly, with no effect by inhibiting PLC-b (Fig 5A), strong down -regulation of collagen I levels after inhibition of PC-PLC (Fig 5B), and similar collagen I ... subunit of Gai [45] was inhibited specifically by U73122 [46] Inhibiting PLC-b by U73122 did not alter ET-1- induced collagen I synthesis, nor did it influence b...
Báo cáo Y học: Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein doc
... human and a murine NICN1 cDNA clone from the IMAGE collection and determined the complete sequences of these cDNAs The comparative analysis of the human, canine, and murine NICN1 cDNA revealed a ... CACCAGgtcagctgggcctca 423 418 bp (exon 3, 11 4 bp) … CCAAAGgcaagtgactttgca 4 01 bp (exon 4, 72 bp) 495 … CTTGAGgtaagctctctaaca 3 71 bp (exon 5, 10 5 bp) 600 … TTCGACgtgag...
Báo cáo khoa học: Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 docx
... detailed knowledge on how Zn2+ ions modulate the conformation and stability of S100A2 will contribute to a better understanding of the regulation of protein function by metal ions, in particular as a ... be suggestive of partial tetramerization (Fig S1) Chemical stability of holo and apo S100A2 proteins The conformational stability of S100A2- wt and...
báo cáo khoa học: " Identification and characterization of the Nonrace specific Disease Resistance 1 (NDR1) orthologous protein in coffee" doc
... 11 9 11 9 11 8 11 6 11 7 11 9 92 12 6 15 1 14 2 11 8 11 8 11 3 11 2 14 2 14 0 16 6 PFYQGHKN Figure The two coffee candidates for NDR1 protein belong to the NHL family Putative Arabidopsis orthologs of CaNDR1a/b ... Biology 2 011 , 11 :14 4 http://www.biomedcentral.com /14 71- 2229 /11 /14 4 (a) CE (b) 12 0 Page 10 of 17 μ PM PMA2 86 NDR1 47 34 (c) (μg) 10 15 PM...
Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
... I.5 Na+- H+ Exchanger (NHE) The Na+- H+ exchangers (NHEs) are a family of membrane glycoproteins which transport H+ out of the cell in exchange for Na+ with a stoichiometry of 1: 1 In mammalian cells, ... increased 11 2 susceptibility to cell death IV .12 Regulation of intracellular pH as one of the mechanisms of 11 3 NHE- 1 -mediated cell...
Isolation and characterization of the novel human gene, MOST 1
... impact on MOST- 1 function 11 9 MOST- 1 Protein 12 1 Aggregation and implication of MOST- 1 function 12 3 Interactors and their possible function with MOST- 1 126 MOST- 1 Expression and Cell Cycle 13 2 Current ... synchronization studies 94 v 4 .11 Yeast two hybrid screening 10 2 4 .12 Overexpression and RNA interference studies 11 0 CHAPTER 5: DISCUSSION Strate...
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