Functional study of MicroRNA 125b in vertebrate development 2

... 95%, n = 85 m 125 bMO + p53MO m 125 bMO * * 98%, n = 1 12 100%, n = 114 * lp 125 bMO1 /2/ 3 in p53M214K mutant 100%, n = 113 * lp 125 bMO1 /2/ 3 + p53MO lp 125 bMO1 /2/ 3 Figure 20 - Rescue of miR - 125 b morphants ... Log2 fold change in miR - 125 b level 8 ** -2 -4 ** 125 b- AS NC-AS1 125 b- DP NC-DP2 -6 Mock b Log2 fold change in miR - 125 b level a Figure 14 - Validation...

Ngày tải lên: 14/09/2015, 08:42

... Biogenesis of microRNAs 1. 1.3 Targets of microRNAs 1. 2 The role of microRNAs in development 1. 2 .1 microRNA functions in embryogenesis 1. 2.2 microRNA functions in stem cell development 1. 2.3 microRNA ... functions in neurogenesis 1. 3 microRNAs in diseases 11 1. 4 The expression and known functions of miR -12 5b 14 1. 5 Motivation of the thesis...

Ngày tải lên: 14/09/2015, 08:42

... ………………………………….4 1. 3 Regulation of flower development in Arabidopsis thaliana ……………………….9 1. 4 Patterning and differentiation of lateral organs in Arabidopsis thaliana 13 1. 4 .1 The patterning of lateral ... Results…………………………………………………………………………… 11 6 5.2 .1 Protein sequence alignment for GIK1 and GIK2.…………………… 11 6 5.2.2 Expression of GIK2 in inflorescence...

Ngày tải lên: 14/09/2015, 08:46

... reported to be involved in the regulation of flowering and hypocotyl elongation (Xiao et al., 20 09) Overexpression of AHL 22 effectively delays the flowering process in Arabidopsis In spite of these ... transforms the inflorescence meristem into a terminal flower Figure 1: Inflorescence meristem and floral meristem in Arabidopsis thaliana Upper panel: sche...

Ngày tải lên: 14/09/2015, 08:46

... that ABCA1 over-expression raises HDL-C (Vaisman et al., 20 01; Singaraja et al., 20 01) Joyce et al (20 02) provided first proof of a direct anti-atherogenic role for ABCA1: expression of human ABCA1 ... phosphatidylethanolamine (Rye et al., 1999) 2. 2 .2 Laboratory Determination of HDL In routine biochemical analysis, HDL in plasma is assayed as the total cholesterol cont...

Ngày tải lên: 16/09/2015, 17:14

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Ngày tải lên: 01/10/2015, 17:28

... used for RT-PCR were: for the I7 OR (5¢-CGTCAAGGAGAAAAAACCCCGGATCT AAAAAATGGAGCGAAGGAACCACAG-3¢) and (5¢-AG CTGCCTGCAGGTCGACTCTAGAGGATCCTAACCAA TTTTGCTGCC-3¢); for OR17-40 (5¢-CGTCAAGGAG AAAAAACCCCGGATCTAAAAAATGGAGCAGAAAC ... recombination introducing the c-myc-OR17-40 coding sequence, using primers (5¢-CGTCAAGGAGAAAAAAC CCCGGATCTAAAAAATGGAGCAGAAACTCATCTC TGAAGAGGATCTG-3¢) and (5¢-G...

Ngày tải lên: 07/03/2014, 16:20

... AAATGAGCCCAACAAAGCCGAGAAAAACATT AATTTGATGCTCGACAGGCTGCCGCGGAGACATGG CAATCCGGGAGACAGCTGGTGATGAAAA TAGCCACACTTGCAGCCGCGGCCAAAAATG TTAATGGGGATGAGAGCGGTTGCCACTTTCT AGATGGGTTGGCAACTTTCGCTTCAAAA TGAAAACCGCCAGTGCTATTGCTGTGAACA ... TGAAAACCGCCAGTGCTATTGCTGTGAACA CCTGACAGCAACTACGCAGCGTTCTGTTCAG AGCAACTATCCACCGTTCGCTTCAGGGACTG TGCTTCATCTTGCTGACGTGTACGTGGGACT ATGTGTACGTGGGACTGGCACTTCGAAAGC AAAATGGCCTACA...

Ngày tải lên: 08/03/2014, 16:20

... greater and their sizes increased (Fig 2) No such defects were observed in the control group Study on mechanism of multistep hepatotumorigenesis in rat: Development of hepatotumorigenesis 55 ... acute and chronic hepatitis [5, 7, 8, 21] Its activity increased continuously during our study The effect of carcinogenesis on the free radicals concentration needs further...

Ngày tải lên: 07/08/2014, 14:23

... characterizations of miRNA -target interactions involved in growth control and cancer transformation I used biochemical immunoprecipitation against Drosophila Ago1 (Ago1-IP) to isolate and purify Ago1/miRNA/mRNA ... protein (green) and GW182 (blue) GW182 proteins contain an N-terminal AGO-binding domain, which provides multiple binding sites for Argonaute proteins and...

Ngày tải lên: 09/09/2015, 10:17

... role in human emotion perception and social interaction, and has attracted much attention in the areas of pattern recognition, computer vision, human- computer interaction, and humanrobot interaction ... and teachers, and can be employed for animal-assisted therapy (AAT) and animal-assisted activities (AAA) instead of real animals [2] This can partly reduce wor...

Ngày tải lên: 09/09/2015, 10:18

... GENETIC STUDY OF HEMATOPOIESIS IN ZEBRAFISH — CHARACTERIZATION OF ZEBRAFISH UDU MUTANT, POSITIONAL CLONING AND FUNCTIONAL STUDY OF UDU GENE LIU YANMEI (Master of Medicine, Peking University, ... differentiation of hematopoietic cells in udu- /- 94 4.1.2 Identification of the udu mutant gene 100 4.1.2.1 Positional cloning of udu gene...

Ngày tải lên: 14/09/2015, 17:54

... Statistical analysis 50 Chapter Results 51 3.1 Expression and functional analysis of HS3ST3B1 in 51 prostate cancer 3.1.1 Expression of HS3ST3B1 in prostate cell lines 51 and tissues 3.2 Functional analysis ... analysis of HS3ST3B1 in 77 prostate cancer 3.4.1 Clinicopathological parameters of prostate 77 cancer patients in study 3.4.2...

Ngày tải lên: 05/10/2015, 22:31

... deaths TABLE Characteristics of cases and two control groups: Population- based case -control study of smoking on risk of cancer deaths among Chinese men 1989–1991 Characteristic Cases No of subjects ... sex-matched living spouse control design as an alternative control selection for a nationwide population- based case -control study is valid and feasib...

Ngày tải lên: 26/10/2012, 09:48