Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration

... hepatotoxicity in certain groups of patients Kd is the concentration of a drug that results in binding to 50% of the receptors Figure Chemical structure of troglitazone Figure Crystal structure of ... troglitazone caused mitochondrial injury in vitro at high concentrations, troglitazone was allowed to progress to the clinical testing phase stage A hallmark...

Ngày tải lên: 12/09/2015, 11:08

... allowed the characterization of the DNA-binding properties in response to phosphorylation by the sensorkinase SenS Results Cloning of wild-type and mutant senSc and senR genes and purification of fusion ... together, these data confirm the specificity of the SenR- binding sites and corroborate the assumption that phosphorylation of SenR by SenS P al...

Ngày tải lên: 07/03/2014, 10:20

... the APX apoprotein Identification of the heme- binding amino-acid residue in H2O2- inactivated stromal APX To determine which amino-acid residue in the apoprotein was cross-linked to heme, the inactivated ... with H2O2 in the absence of ascorbate On the basis of these results, we propose that the rapid inactivation of tsAPX is at least partly due t...

Ngày tải lên: 30/03/2014, 08:20

... substantial loss in nicotinic receptors in cortex and striatum According to the growing amount of findings, accumulation of amyloid plaques which are the baseline indicator in the brain for AD is interfered ... in response to acute nicotine exposure It furthermore suggests the strong synchronization of hippocampal neural network in the mid phase (ga...

Ngày tải lên: 19/06/2014, 08:20

... little emphasis in the past The objective was to determine the mode of lymphocyte cell death upon exposure to the gaseous phase of cigarette smoke (GPS) in vitro For this purpose, we utilised a well-established ... significantly different (p < 0.62) FACS analysis of Annexin V/PI-stained cells To determine the mode of cell death upon GPS treatment,...

Ngày tải lên: 12/08/2014, 14:20

... decreased in response to all emotional stimuli in depressed individuals who displayed increased amygdala activity 4) The clinical relevance of sustained amygdalar processing can be inferred by examining ... detection of sustained amygdala activity in depressed individuals in response to negative information If depression involves primarily disinhibi...

Ngày tải lên: 07/03/2014, 17:20

... signalregulated kinase ⁄ (ERK1 ⁄ 2) and protein kinase B (PKB) pathways that act downstream of oncogenic protein kinases [10,11] It is increasingly apparent that BIM as a mediator of tumour cell ... a potent inhibitor of mitogen-activated protein kinase ⁄ extracellular signal-regulated kinase kinase ⁄ kinases: mechanism of action in vivo, pharmacokinetic ⁄ pharmacody...

Ngày tải lên: 16/03/2014, 00:20

... RESULTS AND DISCUSSION The Rural - Urban linkages of peri -urban households Rural- urban linkages are defined as various types of flows McNulty (1985) mentions the phrase rural- urban linkage” to mean ... a huge number of formal and informal flows of goods, services, information, capital, and people between rural and urban areas (cited in Trager 1988, p.30) Exa...

Ngày tải lên: 06/08/2014, 19:20

... content of total proteins, amino acids, reducing sugars and sucrose in roots (A, C, E and G) and leaves (B, D, F, and H) and chlorophyll content in leaves (I) of Zea mays plants, previously grown in ... induced by nitrate in both roots and leaves of Zea mays plants The attention was focused on the changes in the pattern of protein s...

Ngày tải lên: 12/08/2014, 03:21

... response to DNA damage may be a consequence of their inability to be ubiquitinated Lysine residues 280 and 284 are ubiquitinated in response to DNA damage Since Tax is ubiquitinated in response to DNA ... previous findings showing that the redistribution of Tax in response to DNA Cytoplasmic localization of ubiquitinated Tax is leptomycin B se...

Ngày tải lên: 13/08/2014, 06:20

... limitation of both types of expression dataset is the granularity of both the sampling and the annotation This implies that many of the co -expression clusters at the level of tissues may not actually ... 'transcriptional logic' is probably not primarily conferred by the expression of TFs, as studies on early patterning might suggest Taken together, our study provides a first...

Ngày tải lên: 09/08/2014, 20:21

... the data The size of the window (span) controls the degree of smoothing and the curves are made robust by iterating the fit within each window discarding outliers In all cases robustifying iterations ... underrepresented in proximity to and within genes [23], probably as a cause of their interference with regulatory processes In mammals the great majority of ge...

Ngày tải lên: 14/08/2014, 17:22

... Hemolymph titers of PO -CHH and ES -CHH in response to changes in dissolved oxygen Hypoxia induced the release of CHHs from the PO and ES of the juvenile crabs (Fig 6) At the initial control normoxic ... of CHH cDNA from the ES [28] Also, we examined the physiological responses of the release and expression of these two CHHs under stressful co...

Ngày tải lên: 16/03/2014, 06:20

... (between and 24 h) used by the authors In another study, 258 differentially expressed genes were identified in C gigas in response to exposure to hydrocarbons for and 21 days [22], and some of these genes ... among the down -regulated genes Expression of herbicide -regulated genes The time-dependent expression of 13 genes that were up -regul...

Ngày tải lên: 30/03/2014, 15:20

... avin si side is highly polar, with two arginines and ionizable side chains such as a histidine and two tyrosines in the FDH domain, with one of the latter being replaced in LCHAO by a phenylalanine ... (M) Fig Inuence of buffer concentration on the kinetics of the avin radical evolution (A) Absorbance variation at 570 nm obtained upon laser excitation of 70 lM FDH domain sol...

Ngày tải lên: 22/03/2014, 21:20