Cell cycle control and fate determination during male gametogenesis in arabidopsis thaliana

... untangle the interdependence of cell cycle and cell differentiation During my PhD study, I used the Arabidopsis male gametic lineage, which consists in two cell divisions and a single cell fate commitment ... which multicellular organisms arise from a single cell During this process, the cell number increases by cell division, and following fate determinat...

Ngày tải lên: 12/09/2015, 09:28

... tumors, emphasizing the importance of overcoming pRB- mediated growth control for tumor progression Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 233 Two classes of human tumors ... differentiation that confers upon pRB its tumor suppressor function Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 237 The in...

Ngày tải lên: 25/10/2013, 21:20

... loratadine alone results in Chk1 activation leading to an increase in the percentage of cells in the G2/M phase of the cell cycle Since Page of 12 the G2/M phase of the cell cycle is one of the ... determined by dividing the density of the released DNA band by the density of the total DNA in the lane (the released DNA band plus the unre...

Ngày tải lên: 09/08/2014, 10:20

... difference Analysis of two-dimensional crystals The study of negatively stained intact inside-out paired membranes can give interesting insight into the packing and ordering of PSII supercomplexes, ... packing of the supercomplex is very similar to the packing in the crystals, as is shown in the fitting of crystal features into the spinach type III megacomplex (Fig 4F) Finally,...

Ngày tải lên: 24/03/2014, 04:21

... tumor-suppressor pathways and cell cycle control during cellular senescence Role of the p53 Pathway in Senescence The tumor-suppressor p53 plays a key role in induction of senescence as evidenced ... (1997) Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts Science 277:831–834 Senescence and Cell Cycle Control 267 Campisi J...

Ngày tải lên: 25/10/2013, 21:20

... on the role of the retinoblastoma gene family in cell cycle regulation and tumor suppression The pRb Cell Cycle Control Pathway: Components and the Cancer Connection The retinoblastoma protein, ... over-expression of D-type cyclins, mutations rendering Cdk4 The Retinoblastoma Gene Family 185 Fig The p16INK4A -pRb and the p19ARF -p53 pathwa...

Ngày tải lên: 25/10/2013, 21:20

... amino termini and one of several protein-protein interaction motifs carboxy ter- The ubiquitin-proteasome pathway in cell cycle control 157 minal to the F-box In addition, some members of the F-box ... lethality in a metazoan The ubiquitin-proteasome pathway in cell cycle control 169 References Agarwal R, Tang Z, Yu H, Cohen-Fix O (2003) Two distinct pathwa...

Ngày tải lên: 25/10/2013, 21:20

... accumulates as cells enter S phase Geminin, an inhibitor of Cdt1 is severely down-regulated upon cell cycle exit Cdt1 is negatively regulated by geminin [12,15], and, during the cell cycle, geminin accumulates ... down-regulated in G0 During the cell cycle, Cdt1 and geminin mRNA levels are mostly stable and protein levels are primary controlled by Fig...

Ngày tải lên: 07/03/2014, 16:20

... mediators in the disease [24] Fibroblast-like synovial cells (FLS) are involved in osteoarthritic synovial inflammation FLS activated by proinflammatory cytokines such as TNF-α and IL-1 show marked increases ... incorporated into cultured FLS and induced to cell cycle arrest, decreased cell proliferation and viability, but also increased expression of RAGE, NFκB p65...

Ngày tải lên: 09/08/2014, 14:22

... study and performed cell cycle analysis PRS performed cell morphological and ultra structural assessment SKS carried out assessment of apoptosis and measurement of caspase-3/6 activities AKS has ... helped to draft the manuscript US has analyzed the data and prepared the manuscript All authors have read and approved the final manuscript Competing interests The authors declare...

Ngày tải lên: 10/08/2014, 10:20

... Regulation of G1/ S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR) Int J Cancer 1998, 78:53-61 Darzynkiewicz Z, Bedner E, Smolewski P: Flow cytometry in analysis of ... distribution and the expression of various cell cycle regulatory proteins in HL-60 cells Figure Effects of LA on cell cycle phase distributio...

Ngày tải lên: 10/08/2014, 22:20

... 2000) CDK protein levels remain stable during the cell cycle, in sharp contrast to their activating proteins, the cyclins The oscillatory expression of most cyclin proteins during cell cycle progression ... C-terminus of TRIP- Br2, which includes the putative C-terminal NES of TRIP- Br2, stabilized TRIP- Br2 in G2/M phase 189 Figure 30E Inhibition of nuclear...

Ngày tải lên: 13/09/2015, 20:18