haracterization of tumor suppressor genes hDAB2IP and DLEC1 in hepatocellular carcinoma

... CHARACTERIZATION OF TUMOR SUPPRESSOR GENES hDAB2IP AND DLEC1 IN HEPATOCELLULAR CARCINOMA QIU GUO-HUA (M.SC., China) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF PHYSIOLOGY ... in HCC and then to investigate the methylation status of these genes The thesis will focus on the candidate tumor suppressor genes hDAB2IP and DLEC...

Ngày tải lên: 11/09/2015, 16:07

... participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... suppressor genes could be methylated in lung cell lines and tumors Next, we determined whether the methylation status of such genes could contribute for lung...

Ngày tải lên: 18/06/2014, 16:20

... mark, emphases the possibility that numerous other natural compounds can take the same pathways leading to apoptosis apoptosis in colorectal cancer by activation of p53 and p73 which are negative ... carcinoma cells Anticancer Drugs 2003, 14:193-202 103 Yagi Y, Fushida S, Harada S, Kinoshita J, Makino I, Oyama K, Tajima H, Fujita H, Takamura H, Ninomiya I, Fujimura T, Ohta T, Yashiro M,...

Ngày tải lên: 10/08/2014, 10:21

... 17 1. 9 Cooperative and distinct functions of HDAC1 and 18 1. 9 .1 Redundancy of HDAC1 and HDAC2 functions 18 1. 9 .2 Distinct functions of HDAC1 and HDAC2 19 1. 10 Inhibition of ... 20 1. 11 Biological effects and mechanisms of action of HDAC inhibitors 20 1. 11. 1 Apoptosis 20 1. 11. 2 Growth arrest 22 1. 11. 3 Mitotic disruption and autophagy .....

Ngày tải lên: 10/09/2015, 08:27

... types like RB1 and TP53, many tumor suppressor genes are specific to a particular tumor type and/ or cell type that originate the tumor Deficiency of BRCA1 and BRCA2 is mainly found in breast and ... detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing Genome Biology 2010 11:R114 Page 14 o...

Ngày tải lên: 09/08/2014, 22:23

... aspects of DNA modification by trans-PtHMP and how this modification affects recognition by tumor suppressor protein p53 of the consensus nucleotide sequence to which this protein specifically binds p53 ... (2003) DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]: protein recognition and nucleotide excision repair of monofunctional adducts Biochemi...

Ngày tải lên: 16/03/2014, 14:20

... over the progression of cancer; and the second question is whether the PR domain alone possesses anticancer activity In this study, we quantitatively analyzed the mRNA expression level of RIZ1 ... 2011, activity [19] Since histone methylation has been proposed as an important epigenetic mechanism to suppress cancer, the histone methyltransferase activity of the PR...

Ngày tải lên: 25/10/2012, 11:15

... repression of LMO2 and HGAL Tonsil GC B cells E Cubedo et al PRDM1 binds the HGAL and LMO2 promoters in vivo PRDM1 LMO2 HGAL –2 –1 0.250 0.500 1.000 2.000 4.000 Fig Reciprocal expression of LMO2 and HGAL ... expands this observation PRDM1 repression of LMO2 and HGAL In conclusion, these findings demonstrate that PRDM1 is a physiological transcriptional repre...

Ngày tải lên: 05/03/2014, 23:20

... regulators in S coelicolor Fig Comparative alignment of domains (DNA–protein interaction), (dimerization and metal binding) and (containing a nonconserved amino acid stretch), of the Streptomyces coelicolor ... on DNAÆprotein interaction and of domain in the protein dimerization and metal binding (see the Discussion) There are important differences between DmdR1 and...

Ngày tải lên: 16/03/2014, 18:20

... detection of cellular retinoic acid binding proteins I and 3570 R.-Z Liu et al 15 16 17 18 19 20 21 22 23 24 25 26 27 28 II with new antibodies J Histochem Cytochem 46, 11 03 11 11 Zetterstrom RH, Lindqvist ... (19 90) Retinoic acid receptors and cellular retinoid binding proteins I A systematic study of their differential pattern of transcription during mouse organo...

Ngày tải lên: 16/03/2014, 22:20

... the biological functions of MTSS1 and its role in oesophageal squamous cell carcinoma Page of 10 Table Clinical data of the patients with oesophageal squamous cell carcinoma Clinical data Grouping ... Correlation between MTSS1 expression and oesophageal squamous cell carcinoma patient survival Of the 105 oesophageal squamous cell carcinoma pat...

Ngày tải lên: 18/06/2014, 19:20

... oesophageal squamous cell carcinoma We also provide new insights into the biological functions of MTSS1 and its role in oesophageal squamous cell carcinoma Page of 10 Table Clinical data of the ... pathology and prognosis of the patients with oesophageal squamous cell carcinoma Cellular function tests further demonstrated that the presence of...

Ngày tải lên: 20/06/2014, 04:20