Role of hydrogen sulfide in the pathogenesis of parkinsons disease
Role of hydrogen sulfide in the pathogenesis of parkinsons disease
... contains the N-terminal heme-binding domain, the catalytic domain, and the C-terminal regulatory domain Two other gaseous transmitters, CO and NO, can bind to the heme-binding domain and result in ... be elevated in the SN from parkinsonian brains (138) In support of these findings, epidemiological studies reveal a role of neuroinflammation in the progression of PD given that in a prospective ... neurodegeneration and the underlying mechanisms were investigated in both in vitro and in vivo studies Neuroinflammation is one of the main pathological causes/features of PD In this thesis, the effect of H2S...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... THE ROLE OF HYDROGEN SULFIDE IN THE CENTRAL NERVOUS SYSTEM: IMPLICATIONS IN TREATMENT OF ALZHEIMER’S DISEASE BHUSHAN VIJAY NAGPURE (M.B.B.S., Maharashtra University of Health Sciences, India) ... lot of efforts have been put into the development of disease- modifying drug therapy Amyloidogenesis is one of the main culprits of AD pathology The effect of NaHS, a rapid exogenous hydrogen sulfide ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation...
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Role of hydrogen sulfide in the cardiovascular system implications for treatment of cardiovascular diseases
... alkaline conditions and in the presence of DTT, a strong reducing agent 64 Therefore, the physiologic relevance of 3- MST as a source of H2S formation in brain remains to be elucidated in the ... Renin is the rate-limiting enzyme involved in renin-angiotensin system Renin elevation occurs during pathological states of renal ischemia (renin in systematic circulation) or cardiac remodeling ... epidemiology Cardiovascular diseases (CVD) are the leading cause of death in the world In 2004, it accounts for 32% of all deaths in women and 27% in men By 2030, it was projected be the leading cause of...
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MicroRNA expressions in the MPTP induced parkinsons disease model with special reference to mir 124
... important role for miR- 124 in the survival of dopaminergic neurons in the MPTP- induced PD model In order to analyze the significance of the miRNA expression changes in the MPTP- induced PD model, a PD-specific ... lead to PD is still uncertain Owing to the large size of the protein, changes in specific domains might lead to modifications in the interaction of the protein with other factors leading to the ... disease- inducing pathways has been increasingly demonstrated Owing to the difficulty in obtaining human PD brain tissues and the variations in the time of obtaining the PD tissues, there have been...
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The role of hydrogen sulfide in normal and ischemic heart
... Summary Ischemic heart disease is the leading cause of death in the western society and a major health problem in developing countries In the current study, the role of hydrogen sulfide (H2S) in the ... blood flow into and out of the heart A region of the heart called the sinoatrial (SA) node is capable of producing and discharging an action potential and sending the impulse across the atria ... the abnormality in H2S level is a cause or simply a consequence of these diseases There is also growing interest in understanding the role of H2S in pain appreciation Administration of either...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University ... and 4b) These results suggest that GCT-CM enhanced the chemotaxis and cell proliferation of OPCs via VEGF-Flt-1-FAK signaling Possible involvement of the VEGF-Flt-1-FAK pathway in the bone destruction...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients and tissue specimens The Institutional Review Board of Kyushu University ... and 4b) These results suggest that GCT-CM enhanced the chemotaxis and cell proliferation of OPCs via VEGF-Flt-1-FAK signaling Possible involvement of the VEGF-Flt-1-FAK pathway in the bone destruction...
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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx
... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... epiphyseal dysplasias (MEDs), and the metaphyseal chondrodysplasias They are usually inherited as fully penetrant autosomal dominant disorders The expression of the OA phenotype occurs early in ... lubrication of the cartilage surface [82] The synthesis is impaired in arthritic joints and downregulated by inflammatory cytokines such as IL-1 Mutation at the progressive ankylosis (ank) locus in the...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discs Immunohistochemical staining for collagen phenotypic markers in chondrocyte-like cells from human intervertebral ... Suda A: Cathepsin G in degenerating and healthy discal tissue Clin Exp Rheumatol 1999, 17:197-204 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the human intervertebral disc Comparison ... every other day Assessment of re-differentiated state in alginate To ensure that the phenotype of cells treated with IL-1 were similar to the phenotype of cells within the IVDs in vivo, the cell...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... have resulted in a better understanding of the role of the complement system and FcγRs, although the relative contributions and the hierarchy of these two pathways in the manifestation of disease ... both the FcR and complement system, as part of the innate immune system, are involved in early immune defense and subsequently activate and instruct the adaptive immune system; at the same time they ... for injury to skin and peritoneum [53] Another elegant study in an IC-induced inflammation model argued for a codominant role of inflammatory pathways mediated by FcγRI/III and C5aR [54] In support...
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Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx
... other CFU-M lineage cells because it is expressed solely by cells on the bone The findings supporting a role for osteoclasts in the pathogenesis of peri-implant osteolysis have important clinical ... Research & Therapy Vol No Shen et al Figure Detection of β3 integrin in sections of human peri-implant by immunohistochemistry using a rabbit polyclonal antibody (a, b) β3 Integrin is evident in antibody ... neither the β3 integrin nor the CTR are expressed by osteoclast precursors The expression of these genes increases during the late stages of osteoclast differentiation [42], after induction of the...
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Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF participated in the design of the study and interpretation of data JAH conceived the study, secured ... cells of the aging and degenerating intervertebral disc: immunolocalization of senescence- associated beta-galactosidase in human and sand rat discs Spine 2007, 32:321-327 Martin JA, Buckwalter JA: ... junction of IAF and OAF or of NP and IAF were not included in the analysis Within each area, five fields of view were analysed and the percentage immunopositivity was calculated Data were non-parametric,...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... strongly to α-actinin [12,13] Moreover, an increase in serum anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin ... followed by Manson and colleagues [1] were being treated, and anti-α-actinin antibody titers may decrease with therapy Finally, perhaps anti-dsDNA antibodies not measured by the assay used in this ... candidate in murine lupus Furthermore, high titers of anti-α-actinin antibodies were present in the serum and kidney eluates of LN mice [8] Our results confirmed and extended those reported by Mostoslavsky...
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Báo cáo y học: " Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus" potx
... abnormalities in systemic lupus erythematosus Curr Immunol Rev 2005, 1:61-67 Perl A: Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren’s syndrome ... regulates mammalian target of rapamycin activity and TCRζ expression in SLE The mammalian target of rapamycin (mTOR) is a serine/ threonine protein kinase and a sensor of the Page of mitochondrial transmembrane ... IL-12Rβ2 via cGMP Together, these data indicate that NO has a crucial role in the regulation of Th1/Th2 polarization Nitric oxide regulates T lymphocyte activation in systemic lupus erythematosus Considerable...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... circulating cytokine, coupled with the high specificity and high affinity of binding for the cytokine, makes the soluble receptor ideal as a cytokine antagonist Soluble recombinant human IL-4 receptor ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of signal transduction molecules including motifs ... chains of the heterodimer are required to initiate intracellular signaling (b) The sIL-4R consists of the extracellular portion of IL-4Rα It retains the ability to bind IL-4 with high affinity and...
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