what role did geography play in the rise of greek citystates

... a well-defined hyperintensity mass in the cervical area. The shape of the uterine cervix is distorted in the DWI (arrowhead). d On the ADC map the tumor is hypointense (arrow) and the normal ... imaging technique (SENSE factor of 2). Imaging time of DWI was 90 s for 20 slices. Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue. On the other ... with uterine leiomyomas and a bleeding cyst. a Axial T2-WI shows an area of hypointensity in the center of the cystic component (arrow). b On T1-WI with fat suppression the area in the cystic...

Ngày tải lên: 13/02/2014, 06:20

... Theory of the Good 149 6.1.1 Some Rather Formal Remarks on the Good 149 6.1.2 A Theory of the Good in Broad Outline 154 6.1.3 The Outline and What We Should Do 165 6.1.4 The Outline, the ... happenings, and then simply directs agents to do what is in their power to produce those states of affairs or sets of happenings. 20 In the light of the above remarks, the striking thing about ... welcome thee, or naked and clothe thee? And when did we see thee sick or in prison and visit thee?’ And the King will answer them, ‘Truly, I say to you, as you did it to one of the least of these...

Ngày tải lên: 15/02/2014, 00:20

... functional mapping of the cyclin B1 promoter did not yield the class II CHR as the site through which Lin-9 exerts its control [94]. In another report, depletion of Lin-9, Lin-37, Lin-52 or Lin-54 by RNAi ... Dimethyl sulfate footprint- ing of the CDE in the presence of SV40 large T indi- cated a loss of protein occupation on this site in vivo [79].Elevated expression of cyclin A, cyclin B, Cdc25C and Cdc2 ... appears stronger in G 2 ⁄ M than in G 1 [44]. This contradicts repression through a complex in G 1 and in vivo foot- printing results in the original definition of the sites [10]. Taken together, the sites in...

Ngày tải lên: 16/02/2014, 09:20

... TGF-aD152 (lacking the last eight amino acids of the ICD) compared to the TGF-a D158 construct lacking only the last two valine resi- dues, suggesting a role for an internal motif in the interaction ... identified the EWV 614 motif in MT5-MMP ICD as comprising an important sequence for the interaction with the PDZ proteins: Mint-3, AMPA binding protein and gluta- mate receptor interacting protein (GRIP). ... lane 4), therefore confirming the interaction of these two proteins previously observed biochemically [37] or using a yeast two-hybrid assay [39]. Interestingly, in the M2H system, the interaction...

Ngày tải lên: 18/02/2014, 04:20

... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati, OH, USA) constantly maintained at 1% O 2 . Culture medium ... lgÆmL )1 insulin, 1 lm dexamethasone, and 0.5 mm IDM). Cells were then maintained in DMEM con- taining 10% fetal bovine serum and 1 lgÆmL )1 insulin. The medium was replaced every other day. ... cultured in DMEM containing 10% fetal bovine serum. OP9 cells were grown in aMEM containing 20% fetal bovine serum. C2C12 cells were maintained in DMEM containing 10% fetal bovine serum. Adipogenic...

Ngày tải lên: 18/02/2014, 08:20

... folding of the mutant. The lower intensity may arise from partitioning of the protein into an aggregated state. The effect of copper binding on the secondary struc- ture was determined using CD in ... important in the brain, there- fore the role of copper binding or loss of its binding could be related to specific cerebellar function(s) of stefin B [18], which remains to be seen by more in vivo studies. Stefin ... human cystatins. Further support for the premise that the C-terminus could be the copper binding domain comes from stud- ies of the P79S mutant, which differs from the copper binding forms of stefin...

Ngày tải lên: 19/02/2014, 06:20

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs, thereby releasing the nucleocapsid into the lumen of these vesi- cles. Then, the capsid uses these intra-endosomal ... mild developmental delay. The protein defective in this disorder is also a NHEJ protein. The distinct clinical features of the patients will be discussed in the context of the protein function. 3.4 Diabetes, ... be due to increased protein damage and/or decreased elimination of oxidized protein. Since the proteasome is in charge of protein turn- over and removal of oxidized protein, its fate during ageing...

Ngày tải lên: 19/02/2014, 07:20

... gains independence from the king and his court, and plays a role as a balance against the king’s power. Furthermore, instead of betraying the interest of their country to the court in the metropolis (London) ... the vital importance of the role of the gentry in the development of the Scottish economy as the vital link in the circular flow of the economic system. Thus he wished that the gentry would keep ... western parts of the Roman empire introduced the following form of government into all the nations they subdued. The general of the army became king of the conquered country, and he divided the lands among...

Ngày tải lên: 19/02/2014, 15:20

... proposed X-linkage. Sequence analyses of the ESSS cDNA in these mutants revealed chain termination mutations. In two of these mutants the protein i s truncated at the C-terminus of the targeting sequence; ... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible. From ... and the effect of the absence of intact complex I, but the results are too preliminary in this regard. Heterologous expression of the ESSS-HA subunit The localization of the ESSS subunit in the...

Ngày tải lên: 19/02/2014, 16:20

... thus blocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumour action of BS-RNase is based on the ability of the protein to resist the neutralizing ... plateau. These data indicate that the cell sulfhydryls responsible for the exchange with the protein disulfides are located in the plasma membrane. Furthermore, they show that, as proposed in the hypothesis ... hypothesize that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulfide bonds, with their potential chemical instability. It is well known that in the...

Ngày tải lên: 20/02/2014, 11:20

... demonstrates the important role of GALA in the degradation of both linear and L -arabinose-substituted galactan side chains of pectin. This is in agreement with a previous study in which the synergy of ... under the control of the xylanolytic activator protein [32,41]. The increase in expression levels of galA in the CREA mutant, indicates that at least one of the detected putative CREA binding sites ... synergy of enzymes degrading the pectin side chains was studied [34]. GALA had a positive effect on the activity of the other enzymes involved in the degradation of these side chains. DISCUSSION A....

Ngày tải lên: 21/02/2014, 01:21

... imaging of the brain was also performed in a subset of patients in this study. 36 It was found that use of corticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. ... Vietnam. Following the publication of this trial, Prasad and Singh 12 updated their Cochrane systematic review on the efficacy of corticosteroids in TBM. 12 The combined mortality in the control...

Ngày tải lên: 06/03/2014, 04:20

... scavenging, hunting and gathering in favour of animal husbandry and agriculture. In this chapter, I have chosen to outline some of the most influential and interesting of these theories. By producing ... underlay the introduction of public slaughterhouses in the Netherlands and the increasingly important role of veterinary meat inspection; and finally, Schwabe (1978) examines early animal medicine ... as they were exploited with due care and respect. Further to this change in theological thinking, from the mid-eighteenth century onwards, there was increasing interest in the welfare of the...

Ngày tải lên: 06/03/2014, 16:20

... which was indeed predicted. The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the CGBP proteins. As seen in the tree, ... little is known about their role in DIDO activity. The combination of domains (domain shuffling) is a driving force in Eukarya in the acquisition of Keywords CGBP; DATF1; DIDO1; DIO; SPP1 Correspondence A. ... modifications of chromatin [9]. Little is known, however, of the functional role of the remain- ing subclass members. In this study, the yeast protein SPP1 (alias cps40), a member of the COMPASS...

Ngày tải lên: 07/03/2014, 21:20

... of GSK3 (using Li or SB-415286) appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... (1994) The inhibition of glycogen synthase kinase-3 by insulin or IGF-1 in the rat skeletal muscle cell line L6 by wortmannin, but not rapamycin: evidence that wort- mannin blocks activation of the ... phosphatidylinositol 3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L -leucine-induced up-regulation...

Ngày tải lên: 08/03/2014, 08:20

Ngày tải lên: 08/03/2014, 10:20

Ngày tải lên: 08/03/2014, 16:20

Ngày tải lên: 09/03/2014, 00:20

Ngày tải lên: 15/03/2014, 10:20