Modifiers of inflammatory angiogenesis in a murine model 2

... plasmin by plaminogen activators- urokinase plasminogen activators (uPAs) and tissue plasminogen activators (tPAs) (Conaway et al., 20 01) Plasmin has a broad trypsin-like specificity and degrades ... revascularization, inflammatory cell infiltration, and associated synoviocyte hyperplasia, which produce a pannus of inflammatory vascular tissue This pannus covers and erodes articul...

Ngày tải lên: 11/09/2015, 10:03

... formation 11 III Abnormal wound healing 12 1. 3 Cytokines in angiogenesis and wound healing 1. 3 .1 Chemokines in angiogenesis and wound healing 14 14 ii 1. 3.2 TNF-α: proinflammatory cytokine 18 1. 3.3 ... macrophage inflammatory protein-1alpha (MIP -1 ), macrophage inflammatory protein-2 (MIP-2), and tumor necrosis factor alpha (TNF-α) were viii investigated in the i...

Ngày tải lên: 11/09/2015, 10:03

... mice A Corneal angiogenesis at day and day after injury in BALB/c and Rag1KO mice B and C: Quantitative analysis of neovascularization at day after injury The bars show the mean ± SEM of independent ... angiogenesis in the corneal injury model A Corneal neovascularization at day and day after injury in the control and RB6-8C5 treatment groups B and C Quantitative analysis...

Ngày tải lên: 11/09/2015, 10:03

... 17. 02 17.86 20 .41 18.83 28 .00 27 .20 21 . 82 22. 14 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 20 .26 28 .00 28 .00 22 .61 20 . 92 21 .20 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 32. 55 28 .00 28 .00 28 .00 26 .86 28 .00 28 .00 ... 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 28 .00 22 .56 22 .96 28 .00 28 .00 24 .98 28 .00 2...

Ngày tải lên: 09/09/2015, 18:49

... gaggagtttccatcacgaaga gacgtagcctggtgtctcg ccatgtacccagacatccact gagcagcaacatcaccacag cccctcattaagcctcagc ccaagaggtccatggtgttt gaaatccaccaaagctcacg gcggagctcagcaagatg ctaaggccaaccgtgaaaag cacatgaagcagcacgactt ... tggaaccgatcagtgtgagt agaggaagggcgaggaga ctccttctgcagggctttc tcgggctccaaacttctct ctgcggttctgaaaccaaat aagctcaagaaaggaaacatgc ggtgtctgcaagcgagagtt tggcgtggacgactcatac accgcccttggttaaagt...

Ngày tải lên: 09/09/2015, 18:49

... function upstream of the effector caspases in apoptosis and are known as initiator caspases A phylogenetically distinct group of 13 caspases (caspase- 1, caspase- 4, caspase- 5, caspase- 11 and caspase- 12 ) ... caspase- 1 to an influenza A/ Puerto Rico/8/34 (H1N1) virus infection of RAW264.7 murine macrophages, in vitro To investigate the role of ca...

Ngày tải lên: 13/10/2015, 16:41

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên: 18/06/2014, 19:20

... 1: faint staining; 2: small amount or weak staining; 3: moderate staining; 4: abundant or strong staining; 5: Abundant or very strong staining Means for each group were determined using the individual ... immediately following ablation Panels f-l are CD3+ stained tumor sections from LA treated animals collected at day post treatment Panels f and g depict CD3+ staining of a vascular la...

Ngày tải lên: 18/06/2014, 19:20

... murine brain: (1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of ... used as internal control and untreated control animals (n = 10) were analyzed for baseline evaluation of intracerebral cytokine profiles in these mice (2) In the...

Ngày tải lên: 19/06/2014, 22:20

... appearance of "mature" amyloid plaques [26,30] These plaques contain fibrillar amyloid peptide and as such can be detected by thioflavine, a reagent that stains proteins in beta sheet conformation ... with oligo A or fAβ Characteristic of fibrillar amyloid plaques in both human AD brain and in mouse models of amyloid accumulation is robust association of activated ast...

Ngày tải lên: 19/06/2014, 22:20

... this article as: Virgili et al.: Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis Journal of Neuroinflammation 2011 ... by diazoxide treatment We conclude that oral administration of diazoxide constitutes an appropriate therapeutic approach for treating MS and other de...

Ngày tải lên: 19/06/2014, 22:20

... hematoxylin and eosin stained major organs (Figure 5) Taking all these data into consideration, it appears that combination therapy of AdhTERTHRP/IAA and AdCMVmIL-12 had the best therapeutic effect in ... immunosorbant assay; TUNEL: terminal deoxynecleotidyl transferasemediated dUTP nick-end labeling; ALT: alanine transaminase; AST: aspartate aminotransferase; BUN: blood urea nitrog...

Ngày tải lên: 20/06/2014, 03:20

... 1: faint staining; 2: small amount or weak staining; 3: moderate staining; 4: abundant or strong staining; 5: Abundant or very strong staining Means for each group were determined using the individual ... When applied as a minimally invasive technique, thermal ablation has a number of potential advantages including significantly lower morbidity, minimal destruction of normal liver...

Ngày tải lên: 20/06/2014, 03:20

... 5'-GCCTCCAGCATGAAAGTCTC, 3'-TAAAACAGGGTGTCTGGGGA), IL-1β (5'-TGCACGATGCACCTGTACGA, 3'-AGGCCCAAGGCCACAGGTAT), IL-6 (5'-GTTCCTGCAGAAAAAGGCAAAG, 3'-CTGAGGTGCCCATGCTACATTT), matrix metalloproteinase (MMP)-3 ... DHMEQ inhibits TNF-α-induced nuclear translocation of NF-κB, and does not inhibit phosphorylation and degradation of IκB, or a c-Jun N-terminal kinase (JNK) and a caspase...

Ngày tải lên: 09/08/2014, 07:20

... to a number of factors, including the longevity of the injected protein and the level of free G-actin in the circulation at sites of inflammation inhibiting the DNase I activity Our data obtained ... increase the affinity of the DNase I for DNA, resulting in two improved characteristics – increased specific activity compared to the wild-type enzyme a...

Ngày tải lên: 09/08/2014, 07:20