Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
... unknown The research presented in this thesis focused on elucidating the mechanism of safingol and its potential to synergize with conventional anti- cancer drugs The results presented in Chapter demonstrated ... (OMM) This leads to the release of cytochrome c (Cyt c) from inner mitochondrial membrane space into the cytosol Another pro-apoptotic protein,...
Ngày tải lên: 11/09/2015, 10:02
Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... robust synthesis of pantothenate from low amounts of pantoate [9] Here, we report the results of the structural studies of the pantoate- bound form of the N-terminal domain of E coli PS (nPS) The structure ... [13] Details of the structural basis for the biochemically observed inhibition of plant PS by pantoate, as well as of the alleviation of...
Ngày tải lên: 16/02/2014, 09:20
Click Here: The State of Online Advertising - New insights into the beliefs of consumers and professional marketers ppt
... 44% of consumers feel advertising works better on women than men Professional advertising is the most effective form of advertising, 27% of marketers believe that user-generated content is the ... popular form of online advertising Advertising/Marketing professionals considered in the bottom professions among consumers – along with actors and dancers; not high...
Ngày tải lên: 15/03/2014, 22:20
Báo cáo sinh học: "Making the jump: new insights into the mechanism of trans-translation" pdf
... RNA at the start of translation How then is the resume triplet properly positioned? And what mechanism allows the ribosome to take off from the damaged mRNA template and land precisely on the tmRNA’s ... establish the contribution of the nucleotide residues that precede the resume codon to the correct positioning of the MLD Identifying determinants of template sw...
Ngày tải lên: 06/08/2014, 18:21
X ray crystallographic study of yeast dcp1 and dcp2 proteins insights into the mechanism and regulation of eukaryotic mRNA decapping
... out by the Dcp1- Dcp2 holoenzyme Dcp2 is a Nudix pyrophosphatase and Dcp1 stimulates the activity of Dcp2 The crystal structures of yeast Dcp1 and Dcp2 proteins are presented in this study The structure ... function and regulation of the decapping proteins Dcp1 and Dcp2 Yet several questions still remain open regarding the decapping com...
Ngày tải lên: 14/09/2015, 12:28
Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... N-benzoyl-Phe-Val-Arg-pNA D-Val-Leu-Lys-pNA D-Ile-Phe-Lys-pNA Ala-Ala-Val-Ala-pNA D-Ile-Pro-Arg-pNA Na-benzoyl-Arg-pNA D-Leu-Ser-Thr-Arg-pNA N-succinyl-Ala-Ala-Ala-pNA N-benzoyl-Val-Gly-Arg-pNA N-acetyl-Leu-Glu-His-Asp-pNA ... particular DNA codon for an amino acid at a particular position for this family of plant cysteine proteases The primers used were 5¢-TTGCCTGAGCATGTT GATTGGAGA...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... resolution of 0.1 nm, a response time of s, a bandwidth of nm, and a temperature of 20 °C An average of 10 scans was recorded and corrected by subtracting the baseline spectrum of the buffer The CD signal ... low-resolution structure model of PLDa2 calculated from the SAXS pattern The balls represent the dummy atoms used in the simulated annealing procedure...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... observed with the < /b> single < /b> deletion < /b> mutants < /b> The < /b> membranes from the < /b> D6/D7 double < /b> deletion < /b> strain (VZ4) exhibited the < /b> strongest defect in the < /b> assembly < /b> of < /b> the < /b> catalytic subunits < /b> of < /b> cytochrome < /b> bc1 < /b> complex < /b> ... delays cytochrome < /b> c1 maturation while the < /b> absence o...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... considers the 4541 Interaction of arginase II with substrate and manganese ions ´ V Lopez et al Table Kinetic properties of the arginase activities of wild-type and mutant variants of human arginase II ... activity of the Asn14 9Asp variant, it is clear that the interactions of arginase II with l-arginine and agmatine are greatly altere...
Ngày tải lên: 20/02/2014, 02:21
Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... indicate that the heme attachment itself is not catalyzed enzymatically CONCLUSIONS AND PERSPECTIVE Highly homologous monoheme Class I cytochromes c are available from a wide range of bacteria, from ... established, and are applicable to the elucidation of the dynamic features of cytochromes c It is of interest to characterize cytochrome c with respect to prot...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt
... gels of purified recombinant SR (left) and the PDZ6 domain of GRIP (middle) The circular dichroism spectrum of purified PDZ6 domain of GRIP is shown in the right panel (C) D -Serine synthesis by recombinant ... Characterization of SR activation by the PDZ4-PDZ5-PDZ6GAP2-PDZ7-end module of GRIP D -Serine synthesis by recombinant SR in the presence of incre...
Ngày tải lên: 30/03/2014, 03:20
Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot
... generated an artificial but functional ET chain composed of Anabaena FNR, bovine Adx and bovine CYP1 1A1 The time course of the reaction followed at 450 nm fit to a mono-exponential process with a ... Kinetic parameters for the anaerobic reaction between FNRrd and Adxox Data calculated from steady-state spectra recorded in Fig 2A at 414 nm Adx concentration dependence...
Ngày tải lên: 31/03/2014, 07:20
Báo cáo y học: "omparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi" pps
... Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi Genome Biology 2011 12:R7 Submit your next manuscript to BioMed Central and take full advantage of: ... investigate the fundamental biology and pathogenicity of dermatophytes [8] Despite the above mentioned phenotypic differences, A benhamiae and T verrucosum a...
Ngày tải lên: 09/08/2014, 22:23
Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx
... targeted by miRNA (y- axis) as the percentage of disorder increases in the proteome The datasets for the transcripts encoding the disordered proteins (burgundy) and ordered proteins (mauve) and the proteome ... highly disordered proteins with the highly ordered proteins, an increase of 23.5% is observed instead of 42.5%, and comparing the disord...
Ngày tải lên: 14/08/2014, 21:20
An investigation into the reality of teaching and learning speaking skills to the 2nd year non-major english students at pre-intermediate level of proficiency at hanoi university of industry
... GRADUATE STUDIES CANDIDATE’S STATEMENT I certify that the minor thesis entitled: An investigation into the Reality of Teaching and Learning Speaking Skills to the 2nd year non-major English students ... VIETNAM NATIONAL UNIVERSITY HANOI COLLEGE OF FOREIGN LANGUAGE POST GRADUATE STUDIES -***** - HOÀNG BÍCH THỦY AN INVESTIGATION INTO THE REALI...
Ngày tải lên: 07/11/2012, 14:50