The roles of PIN1 in the pituitary ganadotropes

... decreases in the absence of Pin1 .125 Fig 3.28: Exogenous Pin1 rescues the interaction between SF-1 and Pitx1 in MEF Pin1 –/– cells 127 Fig 3.29: Mutation of Pin1 binding site in SF-1 ... increase the protein level of ATF3 in gonadotropes These findings would lay the foundation for investigating whether Pin1 plays a role in transcriptional regulation of αG...

Ngày tải lên: 11/09/2015, 09:57

... Global analysis of microRNA target gene expression reveals the potential roles of microRNAs in maintaining tissue identity Zhenbao Yu* , Zhaofeng Jian, Shi-Hsiang Shen, Enrico Purisima, and Edwin ... its targets for their expression Theoretically, the tissues with low level of the expression of the targets of a miRNA are probably the tissues in...

Ngày tải lên: 14/08/2014, 16:20

... INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2 011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE ... THE REGULATION OF HEAT SHOCK GENE HSP70B EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY...

Ngày tải lên: 10/09/2015, 08:27

... regulation of transcription In this project we investigated the role of ubiquitin in the regulation of the heat shock gene HSP70B Through RNA interference of SKP1, a component of an ubiquitin ligase ... Role of Med21/hSrb7 in the Regulation of HSP70B 109 3.7 The Effect of the RNA Interference of Med21/hSrb7 and its Effects on Proteosomal...

Ngày tải lên: 10/09/2015, 08:27

... as the link between the methylation of histone H3 residues lysine 34 and lysine 79 (H3K34 and H3K79) and the ubiquitination of histone H2B, abrogating the methylation of H3 while leaving the ubiquitinated ... 2005) 1 .3. 4 E4 Ubiquitin Ligases in the Elongation of Polyubiquitin Chains While the E3 ubiquitin ligases mediate the initial ubiquitination of the s...

Ngày tải lên: 10/09/2015, 08:28

... QUO OF THE GOVERNMENT ON THE ROLES OF SOCIAL WELFARE FOR FARMERS IN VIETNAM TODAY 3.1 ANALYZING THE STATUS QUO OF THE GOVERNMENT S ROLES IN SOCIAL WELFARE FOR FARMERS IN VIETNAM TODAY 3.1.1 Government ... STRENGTH THE ROLE OF GOVERNMENT IN SOCIAL SECURITY FOR VIETNAMESE FARMERS IN THE NEXT FEW YEARS 4.1 CONTEXT OF STRENGTHENING THE...

Ngày tải lên: 25/12/2015, 17:21

... valuable to distin- Blue-light active flavoproteins guish the protonation state of flavin semiquinones by means of the signal width of its typical inhomogeneously broadened EPR resonance centered ... couplings from protons whose nuclear spins are interacting only very weakly with the unpaired electron spin, e.g protons from the protein backbone within the cofactor binding po...

Ngày tải lên: 16/03/2014, 02:20

... be involved in recognition of the methylated Lys4 amino group Multidomain organization of LSD1 and its enzymatic activity in the chromatin context Genes coding for LSD1 ⁄ K -demethylase proteins ... protein–protein and DNA–protein interactions [36] The name of this domain derives from its original identification in the proteins SWI3, Rsc8 and Moira, which are ATP-depen...

Ngày tải lên: 16/03/2014, 02:20

... extended regions of intrinsic disorder [64] From mammalian cells to yeast: a homologous system in a unicellular organism All of the initial studies indicating a role for QR in stabilizing transcription ... metabolic stability of a subset of cellular proteins Quinone reductase as regulator of the proteasome A Molecular mechanism of interaction Protection against 20S...

Ngày tải lên: 16/03/2014, 02:20

Ngày tải lên: 22/03/2014, 16:20

... demonstrated in the analysis of the role of IFN-γ in models of autoimmunity Early attempts to define the role of IFN-γ in autoimmunity by the administration of IFN-γ or neutralizing antibodies ... heavily influenced by yet other cytokines Conclusion Animal models of autoimmune disease are providing a valuable means of analyzing the functional roles of cytokin...

Ngày tải lên: 09/08/2014, 06:22

... gel 2 .1. 2 Recombinant DNA XI-XII XIII 6 10 11 11 12 13 14 15 16 17 17 18 19 20 21 22 23 25 27 28 28 28 29 29 29 II Table of contents 2 .1. 2 .1 Restriction endonuclease digestion of DNA 2 .1. 2. 2 DNA ... analysis of pancreas development 4.3.3 gcga promoter analysis 96 96 10 3 10 8 11 3 11 6 11 6 11 9 12 1 12 1 12 2 12 5 IV Table of...

Ngày tải lên: 12/09/2015, 08:16

... and cell lines 133 3.2.1.2 Expression profile of BNIPXL in murine tissues and cell lines 134 3.2.2 Domain architecture of BNIPXL constructs 140 3.2.3 BNIPXL contains a functional protein-protein ... analyses of the BNIP-2 family 129 3.2 Investigating the biochemical and cellular functions of 133 BNIPXL 3.2.1 Expression profile of BNIPXL 133 3.2.1.1 Expression p...

Ngày tải lên: 16/09/2015, 08:31

... Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in cell cycle 69 5.3 Role of miR-193a in cell cycle 73 5.4 Roles of miR-122a, miR-96 and miR-107 in cell cycle 78 ... Over -expression of let-7 in cancer cell lines alters cell cycle progression and reduces cell division, and it has been shown that multiple ge...

Ngày tải lên: 05/10/2015, 22:31

... Differential expression of miRNAs during cell cycle phases 67 5.2 Role of miR-210 in cell cycle 69 5.3 Role of miR-193a in cell cycle 73 5.4 Roles of miR-122a, miR-96 and miR-107 in cell cycle 78 ... Over -expression of let-7 in cancer cell lines alters cell cycle progression and reduces cell division, and it has been shown that multiple ge...

Ngày tải lên: 06/10/2015, 20:35