... role inthe cardiovascular system and reperfusion injury Thus, we also investigated the time course of H2S production and its possible role inthe rat model of MI/R The main findings ofthe present ... domain homologous to the cytochrome P450 reductases and an amino-terminal oxygenase domain containing a haem prosthetic group, which are linked roughly inthe middle ofthe protein by a calmodulin-binding ... vessel endothelium is now known to be expressed within the heart, inthe endothelium in both the endocardium andthe coronary vasculature (including capillary and venular endothelium), in cardiac...
... of lack of relevant data They used the education ofthe total labor force in a state for the measurement ofthe quality ofthe labor force of individual industries within the same state But the ... number of men and e1 the proportion ofthe workers inthe lth category of labor services, one may write the index ofthe total labor input inthe form: L = —+—+ H N — Thus, to eliminate errors of ... attainment; on the quality of his education (quality ofthe school facilities); and other knowledge he gained from his educational training or otherwise, inand outside ofthe school These are interrelated...
... available Coding and Code Compression In large measure the coding problems arising in MT andin library work are the same as those occurring in other branches of communication engineering The need ... indeterminacy which does exist inlanguage is the indeterminacy which arises from the mapping of a continuous territory onto a chart with a finite resolving power; it is not the result of an intrinsically ... urgently in MT, because ofthe great bulk ofthe material to be stored, but the mathematical problems it presents are the same as in other fields, except where, as inthe use of thesaurus methods, the...
... Engineering in providing services to the government, the public, andthe scientific and engineering communities The Council is administered jointly by both Academies andthe Institute of Medicine ... president ofthe National Academy of Engineering The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions ... Potential of Women in Academic Science and Engineering (U.S.) Beyond bias and barriers : fulfilling the potential of women in academic science and engineering / Committee on Maximizing the Potential of...
... reorganization ofthe actin filament system, playing a role inthe migration of endothelial cells andin recovery of cells from wounding [40] In a variety of cells, in addition to the induction of hsp25 and ... before the addition of recombinant hsp25, as described in Materials and methods Following isolation and washing ofthe resin, protein was eluted and visualized by SDS/PAGE and Coomassie staining The ... fragment of eIF4G (M-FAG [48,49,52]); containing the eIF4E binding site and central domain of eIF4G (lane vs lane 1), less with the N-terminal domain of eIF4G (N-FAG; lane 3), and not to the C-terminal...
... explained by breed differences (dairy vs beef), that the cows included in this study were Se deficient at the beginning ofthe study, and/ or that the dose of Se used was higher than in other ... diets: it's influence on the selenium status ofthe animals and on the dietary selenium intake of man In Re-defining Mineral Nutrition Edited by: Taylor-Pickard JA, Tucker LA Nottingham, Nottingham ... Se/kg DM), in a ratio of 1:2 on the DM basis By the beginning of May, all the cows had calved and were driven to pasture (0.084 mg Se/kg DM) The mean daily intake ofthe mineral premix was 70...
... For secondary endpoints, 21 of 30 (70%) of subjects inthe 200 mg IV ibuprofen group, and 19 of 31 (61%) of subjects inthe 100 mg IV ibuprofen group, compared to of 28 (32%) ofthe placebo group ... for the first time inof 224 ibuprofentreated patients (3 percent) and 13 of 231 placebo-treated patients (6%, P = 0.11) Gastrointestinal bleeding was reported in nine patients inthe ibuprofen ... participants inthe order they were enrolled, based upon stratification The randomization block size was four The randomization block size was not revealed during the course ofthe study to assist in maintaining...
... (including duplicates) A review of these abstracts (JLM, PLG) identified 115 papers of potential interest including review papers The published text of 31 ‘randomized’ clinical trials, including ... as the underlying risk of mortality increased the log odds mortality under steroid treatment decreased (Table 5) The removal ofthe CSG study [32] attenuated the negative slope ofthe line Inthe ... representation ofthe effect The vertical straight line denotes null effect (odds ratio (OR) = 1) The individual points denote the OR for each study andthe lines on either side the 95% Bayesian credible intervals...
... decision-making field of strategic management has used the concepts of uncertainty from these disciplines and applied them to the issues ofthe firm, including the existence andthe boundary ofthe firm Transaction ... finding these types of uncertainty inthe two theories, the interactions among these types of uncertainty are examined Multidimensionality of uncertainty does not necessarily mean that types of ... importance, but also they are interested inthe value and cost of information When the benefit of collecting and processing information about the fut ure states of nature exceeds the cost of it, an economic...
... Conclusion consists ofthe conclusion ofthe whole study, the implications for the translation and for theteachingandlearning Limitations in doing the research and suggestions for further studies ... beyond enriching thelanguageand culture of a country which it contributes to, beyond renewing and maturing the life ofthe original text, beyond expressing and analyzing the most intimate relationships ... when the translator reproduces the message ofthe original text inthe SL text in conformity with 29 the current norms ofthe TL, since the SL andthe TL may appear dissimilar in terms of perspective...
... INVESTIGATIONS ON THEROLESOF UBIQUITIN INTHE REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2011 INVESTIGATIONS ON THEROLESOF UBIQUITIN INTHE ... REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY (B SCI (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL ... OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2011 ...
... Each of these modifications has their role inthe regulation of transcription In this project we investigated the role of ubiquitin inthe regulation ofthe heat shock gene HSP70B’ Through RNA interference ... Partner of Skp1 104 3.6 The Role of Med21/hSrb7 inthe Regulation of HSP70B’ 109 3.7 The Effect ofthe RNA Interference of Med21/hSrb7 and its Effects on Proteosomal Inhibition of HSP70B’ Induction ... Ubiquitin Proteomsome System 10 1.3.2 The Structure and Function ofthe 26S Proteosome 13 1.3.3 The Machinery and Process of Ubiquitination in Brief 16 1.3.4 E4 Ubiquitin Ligases inthe Elongation of...
... isoleucine 44 in ubiquitin is the binding site of these ubiquitin binding domains (UBDs) despite the different structural folds in each UBD resulting in minor variations with their exact interaction ... proteins can greatly hinder their ability to bind to ubiquitinated cargo This is mainly due to the ubiquitin molecule interacting with their ubiquitin binding domains and “occupying” these domains ... within the signaling cell and reception ofthe Notch signal inthe receiving cell (Lai et al., 2005) Further investigation into the mechanisms behind the recognition of ubiquitin by proteins functioning...
... directly into the environment [13, 14] The major routes by which the aforementioned environmental toxicants enter the body are through the skin, the lungs, andthe gastrointestinal tract and they ... liquid–liquid and solid phase extractions can be applied for solid samples However they require tedious steps including mincing, shredding, grinding, pulverizing and pressurizing, to render the sample and ... important role inthe disease diagnostics, since the non-biodegradable nature of most metals makes them ofthe most insidious pollutants The monitoring of trace metals in humans is therefore very...
... [5-8] Therefore, determining the level of estrogens in these body fluids would be very important for the study of their rolesinthe carcinogenesis of ovarian and breast cancer The role of estrogen ... numbers of clinical samples is required for a better understanding ofthe role of these compounds inthe progression of ovarian cancer From the results obtained using the µ-SPE technique, we infer ... section was then trimmed off from the main membrane sheet The former was then cut (at ~1.5 cm intervals) into individual (2 cm × 1.5 cm) pieces One ofthe two open ends of each piece was then heat-sealed...
... present in those samples In a biplot, the length ofthe lines approximates the variances ofthe variables The longer the line, the higher is the variance Inferring from Figure 3.7, 3-nitroaniline ... andthe aromatic amine, 3-bromoaniline were prominent in most ofthe benign samples The clinical importance of their elevated levels in malignant samples in terms of their rolesin benign to malignant ... 1(PC1)) The closer to the top ofthe diagram, the better the point or axis is represented overall inthe biplot, taking into account the contribution of both the first andthe second (vertical)...
... 310˚C min-1 and 5˚C min-1 to 320˚C (hold for 10 min) µL ofthe sample was injected into the GC-MS in splitless mode andthe total GC-MS analysis time was 55.00 SIM mode employed for the set of target ... probable that the dilution reduced the extent of interferences by the protein (clogging on the membrane) andthe low viscosity ofthe matrix that allowed more efficient extraction Standard safety ... supporting evidence pertaining to the tumor etiology to some extent Unfortunately, the analysis of PCBs and their metabolites in biological fluid and tissue samples involves complex, and time-and...
... has increased inthe recent decade, not only the trace metals but the heavy metals as well The study ofthe role ofthe trace elements has been emphasized inthe search for the possible causes of ... understand the mechanism of metal carcinogenicity Significant differences inthe concentration of various trace metals inthe blood and tissues ofthe cancerous patients compared with the healthy ... research for the determination of trace metal status of individuals and groups [9-11] Nonetheless, inthe case of ovarian tumor, both benign and malignant ovarian cyst fluids are good source of information...
... a retort stand, with the hollow fibre immersed in 1.5 mL ofthe aqueous sample phase contained in a mL vial The organic solvent inthe GC syringe was released into the channel ofthe hollow fibre ... retracted into the GC syringe The hollow fibre was removed, andthe organic extract inthe syringe was adjusted to µL (the rest was discarded) Using the same syringe, µL of BSTFA was withdrawn, making ... being set up for the next extraction process Approximately µL of organic solvent was withdrawn into the GC syringe andthe needle ofthe syringe was inserted into hollow fibre to about 0.2 cm of...