Trinucleotide (CAG) repeat polymorphism of the androgen receptor gene in human disease

... nuclear receptors The androgen receptor The polymorphic region of CAG repeats in the androgen receptor gene CHAPTER 1: CAG REPEAT POLYMORPHISM IN THE 17 ANDROGEN RECEPTOR GENE AND MALE INFERTILITY INTRODUCTION ... TRINUCLEOTIDE (CAG) REPEAT POLYMORPHISMS OF THE ANDROGEN RECEPTOR GENE IN HUMAN DISEASE AMPARO MIFSUD GINER (B Science (Hon...

Ngày tải lên: 11/09/2015, 09:05

... subdomain AR3)13 in N/C interaction and the role of individual amino acid residues in and flanking the 23 FQNLF2 7motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated that AR3)13 ... E., Brinkmann, A.O & Trapman, J (1997) Functional in vivo interaction between the amino- terminal, transactivation domain and the ligand bind...

Ngày tải lên: 17/03/2014, 10:20

... 3 1 1 1 1 )4 71, +467 )4 71 )4 71, )1 16 )3 96 )3 48 )3 48 )3 18, +109, +201 )2 67 )2 19, )1 38, +206 )1 53 )5 3 )5 2 )5 2 +222 +260 +423 +465 +466 a Numbers refer to the position of the 5¢-end of the conserved ... throughout the brain tissue in R6/1 compared to R6/2 mice [29,30] The differences between the two transgenic line...

Ngày tải lên: 16/03/2014, 18:20

... cyclooxygenase pathway PGE2 is the major prostanoid synthesized by lung fibroblasts [11] It can also act on fibroblasts in a paracrine fashion after release from the adjacent epithelial layer [12] In addition ... differential modulation of the translation rate or the rate of internalization and degradation of PAR-1 protein As we and others [15–17,26,33] h...

Ngày tải lên: 30/03/2014, 04:20

... Dinarello CA: Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I IL-1 receptor antagonist inhibits IL-1- induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor ... stimulation with A77 1726 and IL-1 * (c) & A77 1726 increases IL-1 receptor antagonist (IL-1Ra) secretion in human synovial fibroblasts and artic...

Ngày tải lên: 09/08/2014, 01:23

... from synovia from OA and RA patients Discussion The novel finding of the present study is the identification of the key components of the cannabinoid receptor system in the knee synovia of patients ... levels of PEA were similar in the synovial fluid of OA and RA patients Thus, levels in the synovial fluid not simply reflect the leve...

Ngày tải lên: 09/08/2014, 10:23

... Polymorphism of the hereditary sigma virus in natural populations of D melanogaster Genetics 95, 459-465 Fleuriet A (1986) Perpetuation of the hereditary sigma virus in populations of its host, D ... that of a strain of wild origin kept in the laboratory since 1972 (B strain) 2’ It would of course have been easier to inject viral clones into flies...

Ngày tải lên: 14/08/2014, 20:20

... Bidirectional Signalling of the CD137: CD137L System 16 1.9 CD137/ CD137L in Tumor Immunotherapy 19 1.10 Multiple Myeloma and the CD137: CD137L System 23 1.11 Multiple Myeloma and Follicular ... rendering it obsolete Published by the International Myeloma Working Group in 2005, the International Staging System (ISS) for multiple myeloma relies mainly on the de...

Ngày tải lên: 26/09/2015, 10:59

... Tsai MY C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular ... Kruyssen DA The 677C >T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronar...

Ngày tải lên: 03/11/2012, 09:49

... multicellular organisms [15] There are four isoforms (A D) of mammalian MEF2, and they have high homology within the 56-amino-acid MADS box at their N-termini and within an adjacent 29 -amino-acid region ... as the MEF2 domain The MADS box is essential for DNA binding and dimerization, and the MEF2 domain plays an important role in DNA binding affinity as well as an indirect rol...

Ngày tải lên: 30/03/2014, 20:20

... type of collagen in the ECM This research also focuses on the effect of the suppression of the MMP-3 gene on mRNA and proteoglycan production Moreover, the biological effects of the suppression of ... increased cell viability and mitotis Moreover, a suppression of MMP-3 can increase production of GAG and HA For further study, MMP-3 gene suppr...

Ngày tải lên: 20/06/2014, 04:20

... ihcakoT morf ,noppin suvreC ,reed akis ni esaesid gnitsaw cinorhc fo ecnallievruS N orugihsI ,M ihcuiroH ,M arumihsiN ,N akoataK 4112-9012 ,78 ,6002 loriV neG J esaesid gnitsaw cinorhc ot ytilibitpecsus ... ekruoR’O 762-662 ,63 ,5002 teneG minA )murolutroh noppin suvreC( reed akis citsemod esenihC ni )PNRP( eneg nietorp noirp eht fo smsihpromyloP XC naH ,DC uW ,YZ gniN ,MJ gnaY ,XH uiL ,MD oa...

Ngày tải lên: 07/08/2014, 23:22

... catabolic and inflammatory pathways that take place during OA by inducing the synthesis of major catabolic and inflammatory mediators via the p38 and p 42/ 44 signalling pathways Furthermore, PAR -2 upregulation ... study design, acquisition of data, analysis and interpretation of data, statistical analysis, and manuscript preparation NA participated in acquisitio...

Ngày tải lên: 09/08/2014, 10:22

... Regulation of expression of the erm(C) gene Deletions in the regulatory region of erm(C) in staphylococci from animal and human origin were identified by sequencing PCR amplicons obtained using primers ... for reservoirs with different usage of tylosin This indicates that not only have the usage of tylosin selected for macrolide resistant staphylococci (...

Ngày tải lên: 12/08/2014, 15:21

... using the algorithm defined above, and the test statistic calculated This was repeated 1,000 times to estimate the distribution of the test statistic The distribution was estimated in 10 different ... different runs to check that it was stable Using the resulting distribution, the probability of observing the test statistic under the null hypothesis was estimated and d...

Ngày tải lên: 13/08/2014, 09:21