androgens the androgen receptor and prostate cancer

... transcription factor Being the predominant receptor for androgens, AR is the main mediator for the genomic actions of androgens The general simplified pathway for AR activation through androgen stimulation ... years (Lassi and Dawson, 2009) 1.2 Androgens in Prostate Cells Past research has provided strong evidence that demonstrate the role of androgens in fueling prostate cancer growth and development ... Invasion in Prostate Cancer Cells 116 Figure 4.1 A Working Model for Prostate Cancer Development and Progression 126 LIST OF SYMBOLS ADT Androgen deprivation therapy AR Androgen receptor...

Ngày tải lên: 09/09/2015, 10:14

... interaction with the charged clamp [5,36,37] The first and last leucine residue in the LxxLL motif enter the hydrophobic cleft in the LBD, and directly contact amino acid residues within the cleft The variable ... interactions between coregulator ARA (70) and the androgen receptor (AR) Mol Endocrinol 16, 287–300 Shang, Y., Myers, M & Brown, M (2002) Formation of the androgen receptor transcription complex Mol ... modulate androgen receptor N/C interaction To study in more detail the role of 24/25QN in the 23 FQNLF27 motif in AR N/C interaction, these amino acids were substituted by 24/25AA In both the yeast and...

Ngày tải lên: 17/03/2014, 10:20

... with radiotherapy The aim of this study was to investigate the effect of the combined treatment of perifosine and radiotherapy on human prostate cancer Methods Cell culture The human prostate ... interpreted the results of the study, performed the statistical analysis and drafted the manuscript BX and BT oversaw the project completion, analyzed the data and completed the manuscript HI, MS, ... Cells were irradiated in the absence (control) or in the presence of 15 μM and 30 μM perifosine and the colony formation assay was conducted Shown are the means and standard deviation of each...

Ngày tải lên: 09/08/2014, 09:20

... understanding of the roles of diet and exercise in the prevention of age-related diseases, as well as in the recurrence and progression of prostate cancer Nutrition, Exercise and Prostate Cancer ... sliced open and the flesh of the apple is exposed to the oxygen in the air The oxygen atoms in the air interact with the sugar in the apple, forming oxygen radicals These radicals break down the flesh ... precancerous and cancerous areas of prostate tissue Based on these and other observations, evidence is mounting that inflammation and oxidation play key roles in the development of prostate cancer...

Ngày tải lên: 22/03/2014, 16:21

... of the prostate is a locally ablative treatment option for the management of prostate cancer Suitable candidates should have documented prostate cancer that is clinically confined to the prostate ... injury to this muscle The thermosensor is introduced through the perineal skin and advanced until the impression of the tip of the thermocouple can be seen in the sphincter The placement can be ... and the Board of Directors of the AUA Funding of the Panel and of the PGC was provided by the AUA, although Panel members received no remuneration for their work Each member of the PGC and of the...

Ngày tải lên: 28/03/2014, 23:20

... measuring their binding ability to in vitro translated EcR ⁄ USP heterodimers [14,15,19] and found that the ligand-binding affinity to the receptor is affected by the structure of EcR [20] Therefore, the ... determined the cDNA sequences of the EcRs and the USPs (RXRs) of Chilo suppressalis [14] and Leptinotarsa decemlineata [15] Dissociation constants of the binding of PonA to these receptors have ... homologies These USPs and RXRs have similar roles In Orthoptera, it was shown that the RXR can be replaced with the USP of other insects [6,7] EcRs, USPs and RXRs are members of the steroid and thyroid...

Ngày tải lên: 30/03/2014, 04:20

... Editor, Tumor Immunology and Biological Cancer Therapy (edited by iSBTc) Bernard A Fox, PhD President International Society for Biological Therapy of Cancer Acknowledgements From the iSBTc Executive ... monitors and supports the subsection interactions with the iSBTc leadership, its membership and BioMed Central; Tara Withington as Executive Director of the iSBTc provides executive management and ... development of the Society Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results...

Ngày tải lên: 18/06/2014, 15:20

... telomerase activity in prostate epithelial cells and PC However, Table 2: Extended E-D model of breast cancer and prostate cancer Hormone receptor Property Membrane androgen receptor ↑apoptotic ... apoptosis in the absence of androgen is the same as that in the presence of androgen if ionophores are used to cause sufficiently high Ca++ influx [51] In the absence of androgen, the increased ... following the addition of T plus F to end the androgen ablation In the absence of androgen ablation, production of these proteins following the addition of T plus F is not observed This raises the...

Ngày tải lên: 13/08/2014, 16:21

... The nuclear receptors The androgen receptor The polymorphic region of CAG repeats in the androgen receptor gene CHAPTER 1: CAG REPEAT POLYMORPHISM IN THE 17 ANDROGEN RECEPTOR GENE AND MALE INFERTILITY ... on androgens (Zirkin et al., 1989) and suboptimal androgen action could lead to defective spermatogenesis (Aiman and Geiffin, 1982) Androgen action is mediated by the AR, so abnormalities of androgen ... in the primary amino acid sequence between the AR LBD and other steroid hormone receptor, the threedimensional structures of the LBDs of these molecules are quite similar The LBDs of these receptors...

Ngày tải lên: 11/09/2015, 09:05

... some androgen- refractory prostate cancers [13,41] Therefore, both AR + and AR - cells were capable of forming androgen- independent prostate cancer cells as the tumorigenesis progresses to the ... reduced apoptosis, and increased mortality [35] This may explain the abundant AR- cancer cells found in many high grade prostate cancers [38-40] and the failure of androgen deprivation therapies Alternatively, ... some of the cancer cells, it appeared that androgens were not necessarily required for survival of these cells or otherwise they should had been programmed into cell death To elucidate the situation,...

Ngày tải lên: 10/08/2014, 05:21

... Cell lines and cell culture The prostate cancer cell lines LNCaP (p53 wild type, androgen- dependent, highly differentiated), PC3 (p53-/-, androgen- independent, poorly differentiated), and DU145 ... PC3 and LNCaP prostate cancer cells Moreover, we compared the effects of ErPC3 to the effects of the PI3K inhibitor LY294002 LY294002 inhibits the upstream kinase PI3K thereby preventing the ... results from the WST-1 test and flow cytometry may be due to the high standard deviations in the WST-1 test that would preclude the detection of a small combination effect On the other hand, in cell...

Ngày tải lên: 09/08/2014, 09:20

... of androgendeprivation therapy (ADT) and/ or radiotherapy (RT) and were subjected functional magnetic resonance imaging (MRI) pretreatment and and days after onset of treatment Together with standard ... increases the prediction of therapeutic response, we elicited a clinical scenario by using human, androgen- sensitive prostate carcinoma xenografts receiving RT and/ or androgen- deprivation therapy ... between the target outputs and the actual outputs of the network The two steps of the learning process included: a) Forward propagation The value of the calculated output, yj , was compared to the...

Ngày tải lên: 09/08/2014, 09:20

... read and approved the final manuscript JV, JRo and AF prepared the design of the manuscript; SV made the treatment planning and selected the patients; MS managed the experimental schedule and ... of RT, and 15-20 days post-radiotherapy Negative correlation throughout the RT was detected between the NKT cell and T lymphocyte proportion and the volume of the rectum receiving lower and higher ... different 3DCRT techniques (WP and PO) were analyzed and the degree of association was determined between the occurrence and evolution of acute and late GI and GU toxicities and the treatment related...

Ngày tải lên: 09/08/2014, 09:20

... been demonstrated in vitro and in vivo [26,27] Our study analyzes the interactions of irradiation and genistein or estradiol incubation in androgen sensitive LNCaP and androgen independant PC-3 ... experiments and molecularbiological work PT carried out the cell cycle analyses HJ participated in the planning of the experiments and the Western Blot analyses HS conceived the study and helped ... progesterone, and androgen receptors in prostate cancer J Natl Cancer Inst 2002, 94:384-390 Kuiper GGJM, Lemmen JG, Barlsson B, Corton JC, Safe SH, Saag PT van der: Interaction of estrogenic chemicals and...

Ngày tải lên: 09/08/2014, 09:22

... hyperfractionated and accelerated radiotherapy and combined therapy and radiotheapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck BMC Cancer 2006, 6:28 ... enhance the radiation response of tumors However, the improvement in the loco-regional control rate has been modest (within the range achieved with concurrent radiotherapy and chemotherapy) and Page ... transducers in head and neck cancer (SCCHN) Anticancer Res 2005, 25:1871-1875 Raben D, Bianco C, Milas L, Ang KK: Targeted therapies and radiation for the treatment of head and neck cancer: are we...

Ngày tải lên: 09/08/2014, 10:20

... from the start date of radiation treatment The K-M prostate cancer survival censors deaths from non -prostate cancer and men who are still alive at the end of the study period The K-M non -prostate ... http://www.ro-journal.com/content/2/1/17 to the risk criteria of the Canadian Consensus Guidelines [6], 56% of the men had high-risk prostate cancer, 33% had intermediate risk, and 11% had low risk The median radiotherapy dose and ... The K-M non -prostate cancer survival censors deaths from prostate cancer and men who are still alive at the end of the study period Figure shows the K-M median non -prostate cancer survival by age...

Ngày tải lên: 09/08/2014, 10:21

... available at the end of the article diseases [6] Therefore, shortening the period of androgen ablation therapy may protect the patients Androgens and Androgen Receptor in Prostate Cancer Androgens ... AR-positive advanced prostate cancer Figure Androgen and alternative therapy for advanced prostate cancer After androgen ablation therapy, androgen treatment will retard the growth and progression ... castration-resistant prostate cancer [39,46-48] Intermittent Androgen Deprivation therapy is a strategy to periodically perform and terminate the androgen ablation therapy, therefore patients in “off-androgen...

Ngày tải lên: 10/08/2014, 10:20

... tumor Cancer stem cells express known prostate cancerassociated genes The cancer phenotype was validated by confirming the expression levels of several established prostate cancer markers from the ... 79 Prostate BPH - 662 66 Prostate BPH - 665 53 Prostate 63 ± 18.4 667 47 Prostate 61 ± 4.2 687 63 Prostate 74 690 79 Prostate BPH - 693 75 Prostate BPH - 704 64 Prostate (HR) - 003/06 52 Prostate ... protein (IGFBP)-4 and IGFBP-5 Proteolysis of IGFBPs regulates the bioavailability of IGFs, and because of the association between IGF levels and prostate cancer [33], strategies for the direct inhibition...

Ngày tải lên: 14/08/2014, 08:21

... growths on the prostate As the prostate is located just in front of the rectum, and cancer of the prostate usually originates at the back part of the gland, it can be felt during the rectal examination ... Orchiectomy involves the surgical removal of the testicles, where most of the potent androgens, T and DHT are produced This procedure effectively depletes these androgens and curbs the growth of PCa ... They were believed to first transform into the androgen dependent cancer cells when there were abundant androgens After ADT, the androgen dependent cells are eliminated, leaving behind only the...

Ngày tải lên: 09/09/2015, 08:14

... in the northeastern district, E brevicornum in the northwestern and northern district and E.sagittatum in the eastern and southern district respectively In Sichuan province, E acuminatum and ... response The morphology of the ligand binding domain (LBD) of ER, particularly the position of helix 12 is different, depending on the type of ligand that binds to the receptor Genistein binding to the ... highest incidence rates occur in northern Europe, northern America,   Australia and New Zealand, and in the southern countries of South America, especially Uruguay and Argentina (Bray et al, 2004)...

Ngày tải lên: 04/10/2015, 17:05