Studies of the anti cancer potential of flavonoids in human nasopharyngeal carcinoma cells

... C: Insulin and LiCl prevent down-regulation of cyclin D1 induced by luteolin in HK1 cells Fig 3.7D: Insulin and LiCl abrogate the effects of luteolin on CNE2 cells Fig 4.1: Combined effect of ... during the cell cycle where synthesis of both cyclins B1 and B2 is initiated during the interphase and localised in the cytoplasm During the prophase, cyclin B1 migrates fro...

Ngày tải lên: 10/09/2015, 15:53

... Abbreviations xv List of Publications xix CHAPTER INTRODUCTION 1. 1 Parthenolide 1. 1 .1 Introduction: feverfew and Parthenolide 1. 1.2 Chemical structure, metabolism and bioactivities of parthenolide 1. 1.2 .1 ... balance 1. 2 .1 Reactive Oxygen Species 17 1. 2 .1. 1 Definition 17 1. 2 .1. 2 Sources of ROS 18 1. 2.2 Biothiols 19 1. 2.2 .1 Definition 19 1. 2.2.2...

Ngày tải lên: 16/09/2015, 17:14

... focused on the anti- inflammatory activity of parthenolide On the other hand, the anti- cancer potential of parthenolide has rarely been studied Thus, the main objective of this study is to further ... investigate the anti- cancer potential of parthenolide by studying its sensitization effects on cancer cells in response to death receptor ligands To...

Ngày tải lên: 16/09/2015, 17:14

... ethanol- regulated genes were involved using KEGG (Kyoto Encyclopedia of Genes and Genomes) [36] and GenMAPP (Gene Microarray Pathway Profiler) [37] analysis As shown in Table 2, only ITGB4 was found to be involved ... considering the reported high expression of the ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma Gankyrin binds to the cell-...

Ngày tải lên: 31/10/2012, 15:28

... conceivable that the < /b> in < /b> vitro binding conditions are not suitable for simultaneous binding of the < /b> two proteins to the < /b> GC1 ⁄ CA2 SOX10 and Sp1 bind to the < /b> EDNRB promoter in < /b> vivo To investigate whether ... end-labeled with < /b> [c-32P] ATP and used as probes The < /b> SOX10-containing lysates were preincubated for 30 on ice with < /b> or without a c...

Ngày tải lên: 16/03/2014, 13:20

... Nanyang Technological University, Singapore (Silver Best Poster Award) vi THE MECHANISTIC STUDIES OF THE ANTICANCER POTENTIAL OF ARTESUNATE IN HUMAN CANCER CELLS Table of Contents DECLARATION ... ART induced autophagy in human cervical cancer HeLa cells evidenced by the increase of autophagic flux In the search of the mechanisms for ART-induced...

Ngày tải lên: 09/09/2015, 08:16

... the importance of PT in the mitochondrial apoptosis, because in the absence of the hallmarks of PT, including the loss of the inner membrane potential and the rupture of the outer membrane, the ... hypoxia), and they found that the type, strength and kinetics of the target gene profiles depend on the levels of p53 in the cell, the type of in...

Ngày tải lên: 14/09/2015, 14:11

Ngày tải lên: 23/03/2014, 05:22

... Coast University, Florida International University, Florida State University, University of Central Florida, University of Florida, University of North Florida, University of South Florida, and University ... of males We need to engender archaeological interpretation Otherwise, our knowledge of the past is incomplete Archaeological Studies of Gender...

Ngày tải lên: 11/06/2014, 13:10

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial...

Ngày tải lên: 10/08/2014, 05:21

... Upregulation of TRPV4 protein and mRNA across the BCM model 3.1.4 Upregulation of TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast canc...

Ngày tải lên: 02/10/2015, 17:15

... (even in the absence of a complete or even partial understanding of the ‘basic science’ explaining their occurrence) From a therapeutic point of view, the major advantage of targeting pseudoexon inclusion ... several of the newly created enhancer sequences strongly correlate with potential binding to the SR protein class of splicing regulators 846 Therapeutic strategies...

Ngày tải lên: 06/03/2014, 09:22

... the effect Mutations of yeast RNase H2 and archaeal RNase HII of a disease-causing mutation on the activity, stability, and structure of human RNase H2 and the role of the glycine residue fully ... or interactions with other proteins might be perturbed in human cells Alternatively, the mutations in the accessory proteins may not have...

Ngày tải lên: 17/03/2014, 17:20

... Hellio, R & DautryVarsat, A (1995) Endocytosis of interleukin receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains J Cell Biol ... resulting in decoupling of the intracellular interaction (crosstalk) between Jaks associated to the b and cc chains, respectively These interactions are known to...

Ngày tải lên: 17/03/2014, 23:20