Studies of the anti cancer potential of flavonoids in human nasopharyngeal carcinoma cells

... Nanyang Technological University, Singapore (Silver Best Poster Award) vi THE MECHANISTIC STUDIES OF THE ANTICANCER POTENTIAL OF ARTESUNATE IN HUMAN CANCER CELLS Table of Contents DECLARATION ... ART induced autophagy in human cervical cancer HeLa cells evidenced by the increase of autophagic flux In the search of the mechanisms for ART-induced autophagy, we found that ART inhibits mechanistic/ mammalian ... eIF4E binding protein beclin-1-regulated autophagy AMP activated protein kinase artesunate bafilomycin A1 Bax-interacting factor big mitogen-activated protein kinase bovine serum albumin cycloheximide...

... the importance of PT in the mitochondrial apoptosis, because in the absence of the hallmarks of PT, including the loss of the inner membrane potential and the rupture of the outer membrane, the ... hypoxia), and they found that the type, strength and kinetics of the target gene profiles depend on the levels of p53 in the cell, the type of inducing agent, and the cell type investigated (Wang ... suggesting the anticancer potential of this compound However, the molecular mechanisms are largely unknown Therefore, in order to systematically investigate the anticancer properties of Andro, the...

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... Coast University, Florida International University, Florida State University, University of Central Florida, University of Florida, University of North Florida, University of South Florida, and University ... of males We need to engender archaeological interpretation Otherwise, our knowledge of the past is incomplete Archaeological Studies of Gender in the Southeastern United States presents cutting-edge ... Tallahassee University of Central Florida, Orlando University of Florida, Gainesville University of North Florida, Jacksonville University of South Florida, Tampa University of West Florida, Pensacola Archaeological...

... To our Figure Inhibition of trypsin-induced cyclooxidase-2 (COX-2) expression by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in human synoviosarcoma cells Human synoviosarcoma ... Inhibition of trypsin-induced nuclear factor (NF)-B activation by proteinase-activated receptor- 2-inhibiting peptide (PAR2-IP) in synovial cells Human primary synovial cells or synoviosarcoma ... study showed higher expression levels of PAR-2 in human primary synovial cells than in chondrocytes [12] However, the role of PAR-2 in synovial cells has not been well investigated Therefore in the...

... Upregulation of TRPV4 protein and mRNA across the BCM model 3.1.4 Upregulation of TRPV4 in invasive human breast cancer cell lines and tissues 37 37 42 TRPV4 is a positive regulator of breast cancer metastasis ... roles and modes of actions in breast cancer metastasis remain obscure We hypothesize that TRPV4 is a positive regulator in breast cancer metastasis In this project, we focus on understanding the function ... TRPV4 in the BCM cell lines 51 3.7B Immunofluorescence (IF) of TRPV4 in the BCM cell lines 51 3.8 52 The expression of TRPV4 in BCM model was examined using realtime PCR X 3.9A Immunoblotting of TRPV4...

... (even in the absence of a complete or even partial understanding of the ‘basic science’ explaining their occurrence) From a therapeutic point of view, the major advantage of targeting pseudoexon inclusion ... several of the newly created enhancer sequences strongly correlate with potential binding to the SR protein class of splicing regulators 846 Therapeutic strategies aimed at correcting pseudoexon inclusion ... recognition in the normal splicing process [55] First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of the ATM...

... the effect Mutations of yeast RNase H2 and archaeal RNase HII of a disease-causing mutation on the activity, stability, and structure of human RNase H2 and the role of the glycine residue fully ... or interactions with other proteins might be perturbed in human cells Alternatively, the mutations in the accessory proteins may not have the same consequences in the yeast enzyme as they in the ... the substrate binding affinity Binding analyses using BIAcore system To examine whether the mutation of Gly10 to Leu or Pro affects the substrate binding affinity of the protein, the interactions...

... Hellio, R & DautryVarsat, A (1995) Endocytosis of interleukin receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains J Cell Biol ... resulting in decoupling of the intracellular interaction (crosstalk) between Jaks associated to the b and cc chains, respectively These interactions are known to be essential in the formation of docking ... raft-association of the IL-2Rb chain in transformed human NK and fibroblast cells Thus, to better understand the role of lipid rafts in cell growth/ viability -signaling of T cells, in general, and in the unregulated...