Discovery and mechanism of action study of anti viral compounds for dengue virus

... BIOLOGY OF DENGUE VIRUS 1.2.1 Taxonomy of dengue virus Dengue virus (DENV) belongs to the family of Flaviviridae that consists of three genera, flavivirus (e.g dengue virus, West Nile virus, and ... BIOLOGY OF DENGUE VIRUS 1.2.1 Taxonomy of dengue virus 1.2.2 Structure and genetic organization of dengue virus 1.2.3 Viral infection cycle 1.2.4...

Ngày tải lên: 10/09/2015, 15:51

... production restricted to virus -specific cells Ethnicity and HBV genotypes influence the HBV -specific CD8+ T cell repertoire of HBV infected patients The above results show that neither race nor HBV ... Immunodominance of HBV -specific T cells Repertoire composition, quantity and qualitative functional ability are the parameters that define virus specific T...

Ngày tải lên: 10/09/2015, 08:26

... [3,16] To further explore the interaction of the most cytotoxic viscotoxin isoform, VtA3, with biological membranes and obtain information on its mechanism of action, we have applied different ... 79 Analysis of the fungicidal effect of viscotoxin A3 M Giudici et al excitation and emission wavelengths were 360 ⁄ 425 and 362 ⁄ 450 nm for observation of the fluorescence...

Ngày tải lên: 19/02/2014, 07:20

... humoral autoimmunity after immunoablative therapy, we analyzed the avidity of reappearing ACPA-IgG autoantibodies by dichotomizing patients according to their pre-transplantation ACPA-IgG level and ... Low avidity of antibodies against anti-cyclic citrullinated of ACPA-IgG autoantibodies with low avidity protein (ACPA)-IgG (solid lines) before and after immunoa...

Ngày tải lên: 09/08/2014, 10:21

... of an in-depth examination of the biology of acute myeloid leukemia, the drugs rapamycin and genistein, and an evaluation of the advantages of combining high- throughput approaches and functional ... a long period of time On the one hand, the risk factors include heredity, abnormal genetic regulation and genetic makeup of some individuals On the...

Ngày tải lên: 11/09/2015, 09:18

... with the gene of the benzaldehyde lyase and for helpful discussions, the teams of the Swiss Light Source (Villigen ⁄ CH) and of the EMBL outstation Hamburg for their help with data collection and ... involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and Mg2+) and of Dom-a¢ of a neig...

Ngày tải lên: 07/03/2014, 12:20

... DNA with the oligonucleotides TG100 (5¢-GGCCTCATGAAGAAAAAGGTCGTCA TAATT-3¢), and TG101 (5¢-GGCCAAGCTTCTAGAAC TTGAGAACCCTAGC-3¢) (for the P horikoshii CoADR), and TG104 (5¢-CGCGCCATGGAAAAGAAAAAGGTA ... and assayed as above Thiols were quantified by comparison of peak areas to standard curves of those standards Coenzyme A was measured as the sum of the areas of the...

Ngày tải lên: 07/03/2014, 17:20

... number of protein toxins have been purified and characterized from snake venoms [1,2] and snake venoms typically contain from 30 to over 100 protein toxins Some of these proteins exhibit enzymatic ... shown Enzymatic toxins from snake venom monomeric counterparts ncHdPLA2s were isolated from Crotalinae and Viperinae snakes They consist of a basic toxic PLA2...

Ngày tải lên: 14/03/2014, 22:20

... Ó FEBS 2003 Active site residues of UDP-glucose dehydrogenase (Eur J Biochem 271) 15 Fig The mechanism of the reaction catalyzed by UDP-glucose dehydrogenase Cys260Ala mutant ... undeuterated) were determined Ó FEBS 2003 Active site residues of UDP-glucose dehydrogenase (Eur J Biochem 271) 17 enzymatically by running the UDP-glucose dehydrogenase reaction t...

Ngày tải lên: 23/03/2014, 12:20

... time- and dose-dependently inducing LXR target genes Transcript levels of LXR target genes in peripheral blood are relevant and useful biological indicators for clinical development of synthetic LXR ... the presence of LXR and LXR in peripheral blood cells would result in regulation of gene expression, a single oral dose of LXR- 623 was adminis- 3.5 2....

Ngày tải lên: 18/06/2014, 15:20

... presence of additive noise and make the technique more sensitive to variations in length The combined use of Max-Min clustering and a fuzzy preclustering phase allows the analysis of large amounts of ... the analysis and modeling of physiological signals, tools for the structured discovery of diagnostic markers, prototypical representations of biological activity,...

Ngày tải lên: 22/06/2014, 23:20

... experimentally and estimates of the emulsion polymerisation mechanism of synthesis for the obtained core and shell The determination of the polymerisation reaction kinetics of the styrene core and butyl acrylate ... Rp is the polymerisation rate of the styrene core, and k is the rate reaction constant in the formation of the styrene core 3.4 Mech...

Ngày tải lên: 07/08/2014, 14:20

... CNVs, and type large numbers of individuals in order to gain biological insights beyond the initial discovery Materials and methods Array synthesis Arrays were synthesized following standard Affymetrix ... the Bentley et al [20] study, one of the Yoruba was whole-genome sequenced; the Perry et al [13] study examined known copy number variants in 10 Yoruba using Agilent...

Ngày tải lên: 09/08/2014, 20:20

... types of human cancer However, the mechanism of COX-2 in angiogenesis remains unclear In this study, the data showed that down-regulation of COX-2 could significantly inhibit the in vitro and in ... et al.: The function and mechanism of COX-2 in angiogenesis of gastric cancer cells Journal of Experimental & Clinical Cancer Research 201...

Ngày tải lên: 10/08/2014, 10:21

... appreciation of the various levels at which dysfunction can occur and therapy can target Modulation Mechanisms capable of modifying the propagation of nociceptive impulses from the foot to the brain ... Pain in the foot Evaluation of foot pain and identification of associated problems Postgrad Med 1987, 82:154-157 Mann R: Pain in the foot Causes of pain in...

Ngày tải lên: 10/08/2014, 21:23