biology and mechanism of action
Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with ... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths of ... 79 Analysis of the fungicidal effect of viscotoxin A3 M Giudici et al excitation and emission wavelengths were 360 ⁄ 425 and 362 ⁄ 450 nm for observation of the fluorescence of DPH and TMA-DPH,...
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Discovery and mechanism of action study of anti viral compounds for dengue virus
... need to determine its mode of mechanism During the studies to determine the mode of mechanism of NITD770, host lipid rafts (as suggested by chemogenomic profiling data) and cholesterol were confirmed ... 68 3.2.4 Anti-viral activity of compound NITD448 73 3.3 DISCUSSION 75 A STUDY OF THE MODE OF ACTION OF NITD770, A SMALL MOLECULE INHIBITOR OF DENGUE VIRUS 79 4.1 INTRODUCTION ... activity profile of NITD770 in several assays 81 Table 4-2: Sequencing results of the genome of the NITD770 resistant viruses 91 Table 5-1: Effect of sterol inhibitors on DENV and HCV replicon...
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
... comparison of transcriptome profiles of MV411 and THP-1 75 Figure 4.3 Hierarchical clustering of transcriptomic profiles of microarray data 78 Figure 4.4 Linear regression analysis of fold-changes of ... understanding the mechanism of action of drugs (Li, et al., 2007; Frolov, et al., 2003) (Nunoda, et al., 2007) Transcriptomic techniques can survey the expression levels of thousands of genes and ... transcriptomic and proteomic modulations caused by the drug Such a study would go a long way in illustrating the mechanism of action of rapa in AML in its totality and in expanding our cognizance of the...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical ... continued to improve and heal, and her remaining gangrenous toes eventually fell off Her blood pressure at admission was 166/53 with use of Lisinopril, which was dropped and eventually ceased...
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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
... neutrophils, and is a biomarker for inflammation Furthermore, to clarify the LA mechanism of action, we studied the participation of pentoxifylline, a PDE5 and TNF-alpha inhibitor, and morphine, a mu and ... pre-treatment of mice with LA (12.5 and 25 mg/kg, i.p) significantly reduced the volume (μL) of the edema in the 2nd (31 and 41%), rd (30 and 50%) and 4th (23 and 27%) hours after administration of dextran, ... light/dark cycle and food and water supplied ad libitum The experiments were carried out according to the Guide for the Care and Use of Laboratory Animals of the U.S Department of Health and Human Services...
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Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
... study furthers our understanding of the mechanism of action for anti-HIV drug interactions and the efficacy observed for the TDF+FTC+EFV triple combination for the treatment of HIV infection Methods ... Where and represent the individual action of drug or drug 2, while 1,2 represents the combined action of the drug combination The CI values of < 1, = 1, and > indicate synergy, additive effect, and ... and FTC-TP [30]; and (2) DEC or DEC-like complex formation by TFV-terminated DNA and HIV-1 RT in the presence of the FTC-TP or EFV, and by FTC-MP-terminated DNA and HIV-1 RT in the presence of...
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Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
... filtration profile of FRK Crystal of SeMet FRK 3.4 Sample diffraction pattern of SeMet FRK crystal 81 3.5 Crystal structure of HoFRK 85 3.6 Structure based sequence alignment of HoFRK 90 3.7 Stereo ... and the actual UDP ligand Superimposition of one docked-ADP ligand and the actual ADP ligand Superimposition of the catalytic regions of the open SPS-F6P complex (cyan) and the closed SPS-S6PUDP ... (magenta) Schematic diagram of the reaction between F6P and UDP-Glc in the binding cleft of SPS A schematic diagram of the reaction involving FRK and Fructose Top a) SDS-GEL image of purified FRK Bottom...
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The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta
... the point of receptor-ligand binding, upstream of Ras, upstream of Raf, and at the level of or downstream of Raf (Guy et al., 2003; Kim and Bar-sagi, 2004) The study conducted by Casci and colleagues ... representation of the Ras-ERK pathway induced by RTKs 1.3.1.3 The primary structure of Ras isoforms 12 1.3.1.4 Schematic representation of the primary structure of Raf 15 1.6.2 The structure and isoforms of ... Inhibition of the Ras-ERK signaling pathway by Spry 29 1.6.6 Points of action of Spry 30 1.6.6.1 Upstream of Ras 30 1.6.6.2 Upstream of Raf 32 1.6.7 Regulation of receptor ubiquitination and endocytosis...
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Post-Harvest Biology and Technology of Citrus Fruits
... reported in USDA Handbook 66 (2-4 at 5ºC and 10-17 ml CO2/kg.hr at 20ºC) for mandarins and oranges Skin Staining is a Preharvest Disorder Rind Staining Following Skin Abrasions Detection of Wounds on ... ratio of Week Yes No 11/14-18 11/14- 39 42 58 11/28-12/2 11/28- 27 53 47 12/12-16 12/12- 13 63 37 Source: Ivans and Feree (1987) Respiratory Rates of Some Nonclimacteric Fruits Respiration and ... Measuring Soluble Solids Content of Orange Juice Relationship Between Sugar/Acid Ratio And Panelist’s Response To The Question About Willingness To Buy Navel Oranges Number of responses Sampling % samples...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis The mycelium of pregrown ... cell-free extract and water to a final volume of 980 lL The reaction was started by the addition of 20 lL of a 100 mM ATP solution (final concentration mM) and the reduction of NAD was monitored ... propionyl- Ó FEBS 2004 CoA and acetyl-CoA In the presence of both thioesters one might expect an accumulation of succinyl-CoA in the cell and a deadlock of further reactions of the citric acid cycle...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... activity zone of the cytoplasmic fraction (not shown) No activity on PGA was observed when the corresponding medium fraction was concentrated and similarly analysed Mode of action of PelB To examine ... Hiromi K (1970) Interpretation of dependency of rate parameters on the degree of polymerization of substrate in enzyme-catalyzed reactions Evaluation of subsite afnities of exo-enzyme Biochem Biophys ... as the rst and only product on PGA and oligoGalpA On the basis of its mode of action, PelB should be classied as an exopolygalacturonase (EC 3.2.1.67) To date, no crystal structure of an exopolygalacturonase...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
... Scheme shows the reactions of the two-step mechanism of action of TFPI It is shown in the Appendix that Scheme is equivalent to Scheme I of [8] within the area of the applicability of the latter In ... values d and found the values of the hypothetical reactions separately The model of the inhibitory action of the Xa–TFPI complex on the enzyme–substrate complex (model 3) The reaction of X–VIIa–TF ... kind permission of the American Society of Biochemistry and Molecular Biology, Copyright 1998 reconstituted systems of blood coagulation proteins effect of the two-step mechanism of VIIa–TF inhibition...
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Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens potx
... a-helices Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and Mg2+) and of Dom-a¢ of a neighbouring subunit (pyrimidine moiety) ... Dom-a and Dom-c of subunit A with their counterparts in subunit B It is stabilized by a large number of hydrogen bonds The weaker contact results from an association of Dom-a and Dom-b of subunit ... Superposition of the ThDP cofactors of BAL (grey), ALS (cyan), AHAS (green), IPDC (purple), BFD (yellow), CEAS (blue), POX (pink) and PDC (red) together with some residues important for cofactor binding and...
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Báo cáo khoa học: Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis ppt
... facilitate identification of the key substrates of individual SVMPs and enable a better understanding of the molecular mechanism of action of P-III SVMPs Functional role of the non-enzymatic proteins ... Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of ... 68–70) and subsite (residues 98–106) (Fig S4) Mechanism of action Catalytic action The catalytic network in secretory PLA2 resembles those of serine proteinases [75,119,120] The reaction mechanism...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... inhibitory activity of this group of peptides is attributable to their effect on the turnover number of IN, and suggest a different mode of action from that of the rst group The third group of peptides, ... the Vmax and Kcat values; and peptides that bind IN, but have no effect on its activity Structural analysis of their interaction sites within IN provided insights into their mechanism of action ... protein on the basis of the RevIN interaction [55,5863] and following the use of a Rev-derived peptide library [58] With the use of a yeast two-hybrid (Y2H) system and a random peptide library,...
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Báo cáo khóa học: Active site residues and mechanism of UDP-glucose dehydrogenase ppt
... Glu141 and Glu145 are potential candidates In this work, the possibility of imine formation involving Lys204 is examined with the use of H2 18 O, and the nature of the rate determining steps of catalysis ... overnight in TYPG (3 mL) The TYPG media contained g of tryptone, g of yeast extract, 2.5 g of NaCl, 1.25 g of K2HPO4 and 2.5 g of glucose per 500 mL of distilled water For inductions, either the JM109(DE3) ... Samples of UDP-glucose were incubated with substoichiometric amounts of NAD+ in the presence of FMN and oxygen [27,28] The FMN/O2 acts as an NAD+ regenerating system and facilitates purification of...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1,3-b-glucanase was studied using laminarin from L digitata with a ratio of 1,3-b- and Exo-1,3-b-glucanase ... Km and Vmax for hydrolysis of G6G are similar to those of G3G (Tables and 4) Therefore, it may be assumed that the enzyme has a mixed mode of action towards laminarins and that it is capable of ... higher and the rate of hydrolysis is < twofold lower than for laminarin from L digitata The mode of action of the exo-1,3-b-glucanase on laminarin from L digitata was studied qualitatively by TLC and...
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reproductive biology and phylogony of cetacia
... funeral and erected a statue as a memorial of her loving spirit Reproductive Biology and Phylogeny of Cetacea 1.2.4 Carriers of Souls and Ships Stories of the roles and attributes of these ... due to the School of Integrative Biology, University of Queensland, for facilities, and especially to the Executive Dean of the Faculty of Biological and Chemical Sciences, Professor Mick McManus, ... Reproductive Biology and Phylogeny of Cetacea Whales, Dolphins and Porpoises Reproductive Biology and Phylogeny Series Series Editor: Barrie G M Jamieson Vol 1: Reproductive Biology and Phylogeny of Urodela...
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báo cáo hóa học:" Biology and augmentation of tendon-bone insertion repair" pptx
... view of these favorable properties of calcium phosphate, it can be a good candidate for augmentation of healing and hence fixation of tendon inside bone tunnel The osteoconductive nature of calcium ... assistant professor in the Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China Peng Zhang is an Assistant Professor and Director Aassistant of Translational ... Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, in Shenzhen, China Ling Qin is the Professor and Director of Musculoskeletal...
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