3 current status and mechanism of action of platinum based anticancer drugs

... Hospital data Proceedings of the 8th International Conference on Rehabilitation Robotics: 20 03; Daejeon, Korea 20 03: 55-58 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 Hesse S, Schulte-Tigges ... fraction of range and fraction of speed Changes in supported fraction of range and fraction of speed Values are shown for the three preliminary evaluations (weeks 1, 2, and 3) , three post-therapy ... statistics for planned comparison of pre- to post-training 0. 430 (0.12) 1.114 (0 .32 ) 1.400 (0 .32 ) 0.768 (0 .30 ) 0.768 (0.19) 1.618 (0 .33 ) 1.591 (0 .30 ) 2.189 (0.91) 0 .38 5 (0.62) Free reaching 2.671...

Ngày tải lên: 19/06/2014, 10:20

... 2008; 98: 37 2 -37 3 Sander LC, Putzbach K, Nelson BC, et al Certification of standard reference materials containing bitter orange Analyt Bioanalyt Chem 2008; 39 1: 20 23- 2 034 Stewart A, Fernando R, ... Pharmacol 1999; 35 9: 31 0 -32 1 28 Dews PB Caffeine Ann Rev Nutr 1982; 2: 32 3 -34 1 29 Dews PB, O’Brien CP, Bergman J Caffeine: behavioral effects of withdrawal and related issues Food Chem Tox 20 03; 40: 1257-1261 ... ±10 .3 76 .3 ±10.5 76.1 ±8.9 90.1 ±10.4 89.8 ±9.5 87.1 ±9.4 91.7 ±7.0 0.86 ±0.08 0.85 ±0.05 0.84 ±0.05 0.82 ±0.09 56.9 ±6 .3 53. 9 ±8.0 53. 1 ±7.0 53. 8 ±8.8 1 23. 0 ±11.0 120.9 ±11.9 128.1 ±11.4 1 23. 0...

Ngày tải lên: 25/10/2012, 11:10

... phosphorus removal and denitrification (3) Most of the phosphorus in the sludge was solubilized by ozonation, and a large part of the solubilized phosphorus consisted of PO4-P Over 90% of the PO4-P ... concentration On day 23, the amount of sludge to be ozonated was reduced from 23% to 16% of total MLSS per day (Phase 2), and as a result, MLSS concentration was maintained at around 3, 000 mg/L Figure ... Figure Time course of TOC, T-N, and T-P concentrations in the effluent and MLSS in the reactor Figure shows the water quality profiles at day 49 (Phase 2), day 78 (Phase 3) , and day 147 (Phase...

Ngày tải lên: 05/09/2013, 09:38

... of 0.4 mL of blank blood and 0.4 mL of IS- containing pentane solution in a glass vial with a Teflon-septum screw cap, which has been cooled with ice, and vortex-mixed for s; a 3- µL aliquot of ... Assessment and some comments on the method > Figure 8.1 shows gas chromatograms of isobutyl nitrite (injected amount µg) and isobutyl alcohol (injected amount 10 µg); they appeared at 3. 4 and 7.4 of ... investigations J Chromatogr B 734 : 83 89 11) Kielbasa W, Fung HL (2000) Pharmacokinetics of a model organic nitrite inhalant and its alcohol metabolite in rats Drug Metab Dispos 28 :38 6 39 1 12) Seger DL (1992)...

Ngày tải lên: 18/10/2013, 00:15

... of Nerve Agents Ministry of Foreign Affairs of Finland, Helsinki, pp 27, 28, 37 39 , 59–64, 72–79 and 90–99 2) Tsuchihashi H, Katagi M, Nishikawa M et al (1998) Identification of metabolites of ... Chromatogr A 833 :169–179 15) Tu AT (1999) Principle of Toxicology – Science of Poisons Jiho Inc., Tokyo, pp 131 –1 73 (in Japanese) 16) Tu AT, Inoue N (2001) Overall View of Chemical and Biological ... in serum collected from victim of VX murder J Anal Toxicol 22 :38 3 38 8 3) Katagi M, Nishikawa M, Tatsuno M et al (1997) Determination of the main hydrolysis product of organophosphorus nerve agents,...

Ngày tải lên: 18/10/2013, 00:15

... mg/mL solution IR, γCHCl3 1,680 cm–1; NMR (CD3COCD3) δ: 1.08, 1 .39 (s, 3H × 2, gem-CH3), 3. 38 (d, C10a-H), 6.15, 6 .30 (s, 1H × 2, aromatic-H), 8.10 (m, 1H, C10-H); MS, m/z 34 4 (M+) 5′-Nor-Δ8–THC-4′-oic ... d3- and d10- substitution products of the acid are used When ∆9-THC11-oic acid-d3 is used, the mass spectrum shows ions at m/z 433 , 418 and 37 4 with the Derivatization-2, and at m/z 491, 476 and ... method of Ohlsson et al [8] The compound is dissolved in ethanol to prepare 0.1 mg/mL solution IR, γCHCl3 1,710 cm–1; NMR (CDCl3) δ: 1.10, 1 .38 (s, 3H × 2, gem-CH3), 1.70 (s, 3H, C9-CH3), 3. 22...

Ngày tải lên: 24/10/2013, 19:15

... 6-acetylmorphine-TMS: m/z 39 9 (M+), 34 0, 287, 204 codeine-TMS: m/z 37 1 (M+), 34 3, 234 , 178 ethylmorphine-TMS: m/z 38 5 (M+) nalorphine-TMS: m/z 455 (M+) By SIM of GC/MS, a low level of morphine less than ... of morphine, codeine and 6-acetylmorphine, the extraction is made as follows A 2-mL volume of urine is diluted 2-fold with purified water and mixed with 0.1 mL of the IS solution and 0.2 mL of ... Therefore, the detection of low levels of morphine starting from a large amount of a specimen cannot be a proof of the intake of the drug The level of morphine in urine of healthy subjects determined...

Ngày tải lên: 24/10/2013, 19:15

... addition of 20 mg of anhydrous sodium carbonate and vortex-mixed for After centrifugation at 3, 000 rpm for min, 1- or 4-µL of the upper layer is injected into GC Various known amounts of nitrate and ... volume of the supernatant solution is transferred to a new polypropylene tube of the same type, followed by addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene Nitrate and ... nitrogen-phosphorus detector can be used, regardless of its manufacturer and type 6 53 654 Nitrate and nitrite compounds ⊡ Figure 5 .3 Derivatization reaction for nitrite and nitrate used in this method d) In...

Ngày tải lên: 24/10/2013, 19:15

... 30 9, 31 9, 32 0, 39 5, 39 8, 400, 32 7, 33 0, 33 5 33 8, 34 3 34 6, 35 2, 35 3, 35 5, 37 1, 39 1, 39 3, 411, 426, 433 , 477, 478, 485, 502, 5 03, 512, 5 13, 520, 541, 550, 552, 565, 574, 576, 581, 5 83 HPLC-DAD 266, ... 9-anthracenecarboxylic acid 33 1, 33 2 an Oasis HLB cc 260 AP 171, 179–182 APAP 33 5 APAP -3- mercapturic acid 33 7, 33 8 APAP-glucuronide 33 5, 33 6, 33 8 APAP-N-sulfate 33 5, 33 6, 33 8 APC 564 APCI 40, 525 ... 197, 231 , 261, 30 3, 31 6, 38 4, 537 , 5 63, 5 93, 620, 650 DB-5 78, 174, 190, 2 83, 38 4, 456, 4 83, 537 , 5 63 DB-17 160, 167, 220, 231 , 31 6, 38 5, 489, 492, 494, 5 93 DB-210 537 DB-5MS 174, 500, 546, 5 63, ...

Ngày tải lên: 24/10/2013, 19:15

... cocaine** 96.5 (0 .32 ) 962 (3. 17) 1,027 (3. 39) 175 (0.58) 51.6 (0.17) 190 (0. 63) 58.9 (0.19) 222 (0. 73) 4 03 (1 .33 ) 235 (0.78) 127 (0.42) 730 (2.41) * Unit: µg/mL or g and µmol/mL or g in parentheses ** ... (0.27) 41.1 (0.14) 1 03 (0 .34 ) 44 (0.15) 148 (0.49) 171 (0.56) 109 (0 .36 ) 71 .3 (0.24) 655 (2.16) EME 30 .9 (0.16) 242 (1.22) 66 (0 .33 ) 47 (0.24) 2.9 (0.02) 28.5 (0.14) 6.1 (0. 03) 32 .4 (0.16) 41.5 (0.21) ... al (19 93) Solid-phase extraction and GC/MS quantitation of cocaine, ecgonine methyl ester, benzoyl-ecgonine, and cocaethylene from meconium, whole blood, and plasma J Anal Toxicol 17 :35 3 35 8 8)...

Ngày tải lên: 29/10/2013, 01:15

... its concentrations were 9.2 and 3. 3 µg/mL in blood, 43 and 34 µg/g in the liver, and not detectable and 4.5 µg/mL in urine, respectively [12] The blood concentrations of dextromethorphan, which ... history of intravenous use of pentazocine and tripelennamine, T,s and Blues J Forensic Sci 28:489–495 3) Kintz P, Tracqui A, Lugnier AJ et al (1990) Simultaneous screening and quantification of several ... of 3 7 and 7–8 min, respectively The amount of pentazocine and IS spiked into mL of blank whole blood or urine was equally 50 ng ⊡ Figure 5.2 222 Pentazocine Pentazocine In two autopsy cases of...

Ngày tải lên: 29/10/2013, 02:15

... about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3- , 13- and 14-hydroxy-LSDs and an N-de-ethyl-LSD are known [3] After oral ingestion of 160 µg LSD, ... (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) Cody JT (2000) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical ... Darmstadt, Germany and other manufacturers) Developing solvents: (A) acetone/chloroform (4:1, v/v); (B) chloroform/methanol/n-hexane (4:2:1, v/v) Assessment of the method The Rf values of LSD were 0.29...

Ngày tải lên: 08/11/2013, 01:15

... off-white off-white off-white 8.1 8.2 9.1 8 .3 orange light brown mottled light brown mottled Active ingredients (mg)* MDMA 73, AP 4.4 MDMA 87, MA 30 MDMA 83, AP 9 .3 MDMA 120 MDMA 62 290 31 0 32 0 35 0 33 0 ... between the mechanism of action of MDMA, MBDB, and the classic hallucinogens Identification of a new therapeutic class: entactogens J Psychoactive Drugs 18 :30 5 31 3 2) Nichols DE, Hoffman AJ, Oberlender ... 8.4 off-white 9.1 off-white 8.1 off-white 8.2 red mottled 9.1 off-white 8.2 light green mottled 8.2 yellow 8.1 yellow 7.1 bluish purple 7 .3 pink 8.2 Weight (mg) 290 230 250 30 0 290 off-white off-white...

Ngày tải lên: 08/11/2013, 01:15

... analyzer J Anal Toxicol 17: 133 – 137 Phencyclidine 9) Parsons RG, Kowal R, LeBlond D et al (19 93) Multianalyte assay system developed for drugs of abuse Clin Chem 39 :1899–19 03 10) Kandiko CT, Browning ... Kumazawa T et al (1996) Simple extraction of phencyclidine from human body fluids by headspace solid-phase microextraction (SPME) Chromatographia 43: 331 33 3 14) Nakahara Y, Takahashi K, Sakamoto ... fluid, vitreous humor and urine than in blood Villain et al [21] and Elliott [31 ] have tentatively set positive cutoff limits of GHB at 50 and 30 µg/mL for postmortem blood, and 10 and 20 µg/mL for...

Ngày tải lên: 08/11/2013, 01:15

... solution of the free form of chlorpromazine, the amount of chlorpromazine hydrochloride to be dissolved in mL methanol is calculated as follows mg (MW of the free form 31 8.9 MW of the salt form 35 5.4) ... amount of IS and various concentrations of a target compound are added to mL each of blank whole blood or urine, and processed as above At least vials containing different concentrations of the ... Assessment of the method > Figure 1.1 shows a TIC and MCs for phenothiazine drugs obtained by GC/MS Panels A and B show a TIC and an MC for the authentic compounds, respectively; panels C and D those...

Ngày tải lên: 15/12/2013, 12:15

... in 0.1 mL of the mobile phase of HPLC or LC/MS For HPLC-DAD and LC/MS, 50 and 20 µL of the above solution are injected, respectively For the SIM of LC/MS, the ions at m/z 37 6, 37 8 and 422 are ... volume of urine or blood, 0.05 mL IS and 0.5 mL of M NaOH are placed in a 15-mL volume glass centrifuge tube with a ground-in stopper and mixed well, followed by addition of mL of the mixture of ... haloperidol (HP) and bromperidol (BP) (100 ng/mL each) (A) and for a serum extract from a poisoned patient (B) m/z 37 6.5: HP; m/z 37 8.5: HP and RHP; m/z 422.4: BP=IS Poisoning cases, and toxic and fatal...

Ngày tải lên: 15/12/2013, 12:15

... 208 71 58 221 202 295 58 85 234 1 93 58 235 1 93 418 59 70 277 2 03 1 93 72 264 165 202 220 189 91 83 261 70 202 58 249 1 93 99 277 31 3 227 266 234 280 208 191 178 2 63 217 294 *: molecular weight ... 2225 (2242) 238 5 ( 238 0) 2215 (22 23) 239 0 ( 235 6) 2210 (2211) 2255 (2210) 2225 ( 2201) Mass fragmentation ions (m/z)*** 58 202 215 91 245 257 1 93 228 1 93 236 165 58 269 85 31 4 195 235 208 71 58 ... detection of the peak of lofepramine Poisoning cases, and toxic and fatal concentrations In > Table 3. 1, the therapeutic and toxic blood concentrations of each compound are shown [4] For all drugs, ...

Ngày tải lên: 15/12/2013, 12:15

... (82) 38 2 (100), 32 6 (87), 34 1 ( 63) , 35 3 (33 ), 156 (31 ) 34 2 (100), 34 4 (47), 31 3 (37 ), 266 (31 ), 125 (24) 31 3 (100), 31 5 (76), 238 (71), 75 (62), 34 2 (52) 39 4 (100), 39 2 (77), 245 ( 43) , 118 (38 ), ... (100), 2 53 (30 ), 70 (30 ), 105 ( 13) , 77 (12) 31 0 (100), 31 2 (30 ), 32 5 (20), 1 63 (12), 111 (12) 285 (100), 31 2 (99), 31 3 (95), 266 (58), 238 (37 ) 55 (100), 31 3 (67), 109 (61), 287 (42), 259 (37 ), 34 2 ... etizolam triazolam brotizolam 10 .30 10.75 10. 83 10.91 11.56 12. 03 12.42 12.97 13. 32 13. 50 13. 82 295 36 3 38 7 281 31 5 294 30 8 38 2 34 2 34 2 39 2 medazepam fludiazepam diazepam dipotassium clorazepate chlordiazepoxide...

Ngày tải lên: 15/12/2013, 12:15

... the fatal cases of multiple drug ingestion, blood bromisovalum concentrations were reported to be 37 µg/mL by Terada et al [ 13] , 23. 6 µg/mL by Matsubara et al [14], and 31 .5 and 40.8 µg/mL by ... substance and about 35 0 mL of aqueous solution About 35 0 mL urine was present in her urinary bladder Analytical results: g of bromisovalum was detected from the above white clayey substance; about g of ... in formation of white crystal powder, which is collected by filtration, and recrystallized in ethanol The crystals thus obtained show a melting point at 133 – 135 °C Kokatsu et al [3] used 2-bromoisobutyrylurea...

Ngày tải lên: 15/12/2013, 12:15